Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.

1997 • 192 citations

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.

1993 • 178 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.

1985 • 162 citations

A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.

1991 • 158 citations

Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene.

1995 • 145 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function

1997 • 89 citations

The Structure and Function of γс-Dependent Cytokines and Receptors: Regulation of T Lymphocyte Development and Homeostasis

1998 • 88 citations

Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.

1995 • 73 citations

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells

1997 • 69 citations

Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus.

1994 • 68 citations

Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta c chain in primary lymphocyte populations

1998 • 61 citations

Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.

1996 • 46 citations

Requirement for Jak3 in Mature T Cells: Its Role in Regulation of T Cell Homeostasis

1998 • 40 citations

Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice.

1997 • 37 citations

Lymphokine Regulation of Activation-Induced Apoptosis in T Cells of IL-2 and IL-2Rβ Knockout Mice

1998 • 27 citations

Endocytosis of the β chain of interleukin‐2 receptor requires neither interleukin‐2 nor the γ chain

1994 • 23 citations

Biochemical Identity and Characterization of the Mouse Interleukin-2 Receptor β and γ_cSubunits

1995 • 15 citations

Subpopulations of fetal thymocytes defined by expression of T cell receptor/CD3 and IL-2 receptor. CD3 and IL-2 receptor alpha-chain are expressed on reciprocal cell populations.

1991 • 4 citations