Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency

1993 • 475 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Tolerance and Autoimmunity

2001 • 453 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

Identification of α-Fodrin as a Candidate Autoantigen in Primary Sjögren's Syndrome

1997 • 400 citations

The genetics of complex autoimmune diseases: non-MHC susceptibility genes

2001 • 394 citations

Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 • 359 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands

1997 • 253 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

Monoclonal antibodies to stromal cell types of the mouse thymus

1984 • 228 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Analysis of thymic stromal cell populations using flow cytometry

2002 • 206 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

AIRE Mutations and Human Leukocyte Antigen Genotypes as Determinants of the Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Phenotype

2002 • 195 citations

The Autoimmune Regulator (AIRE) Is a DNA-binding Protein

2001 • 172 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

Gene defect behind APECED: a new clue to autoimmunity

1998 • 154 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

PHD domains and E3 ubiquitin ligases: viruses make the connection

2002 • 145 citations

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

2002 • 143 citations

Autoimmune regulator: from loss of function to autoimmunity

2003 • 137 citations

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

1997 • 131 citations

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

1985 • 126 citations

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

2002 • 123 citations

A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice.

1994 • 117 citations

Complexity in a monogenic disease

1996 • 117 citations

Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin.

1990 • 109 citations

Development of Autoimmune Exocrinopathy Resembling Sjögren's Syndrome in Estrogen-Deficient Mice of Healthy Background

2003 • 99 citations

Science, medicine, and the future: Single gene disorders or complex traits: lessons from the thalassaemias and other monogenic diseases

2000 • 94 citations

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

1999 • 83 citations

Prevention and Induction of Autoimmune Exocrinopathy Is Dependent on Pathogenic Autoantigen Cleavage in Murine Sjögren’s Syndrome

2002 • 60 citations

Role of genetic factors in organ-specific autoimmune diseases induced by manipulating the thymus or T cells, and not self-antigens.

2000 • 30 citations

Anti–α-Fodrin Autoantibodies in Moyamoya Disease

2003 • 22 citations

Development of autoimmune exocrinopathy resembling Sjögren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells

2003 • 22 citations