Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioral characteristics

Fundamental Immunology

1999 • 1,011 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

A Role for Skin γδ T Cells in Wound Repair

2002 • 596 citations

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt ⁺ Cells

2004 • 482 citations

Intraepithelial lymphocytes: exploring the Third Way in immunology

2001 • 481 citations

Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine

2002 • 460 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

The gut‐associated lymphoid system: nature and properties of the large dividing cells

1974 • 391 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

1998 • 301 citations

Intraepithelial lymphocytes of the small intestine.

1977 • 287 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V_δ1 gene segment

1991 • 261 citations

T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL

2001 • 257 citations

Oligoclonal Expansion and CD1 Recognition by Human Intestinal Intraepithelial Lymphocytes

1991 • 243 citations

Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes

1987 • 220 citations

Precursors of Functional MHC Class I- or Class II-Restricted CD8αα+ T Cells Are Positively Selected in the Thymus by Agonist Self-Peptides

2002 • 201 citations

Expanding the role of Peyer's patches in B-cell ontogeny

1996 • 197 citations

Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium

1995 • 196 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Extrathymic T Cell Lymphopoiesis

2003 • 180 citations

Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes.

1993 • 174 citations

Oligoclonality of human intestinal intraepithelial T cells.

1992 • 165 citations

Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium

1998 • 155 citations

Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity.

1985 • 150 citations

Extrathymic intestinal T-cell development: virtual reality?

1995 • 149 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

Gut Cryptopatches

2000 • 147 citations

A Keratinocyte-Responsive γδ TCR Is Necessary for Dendritic Epidermal T Cell Activation by Damaged Keratinocytes and Maintenance in the Epidermis

2004 • 134 citations

Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene

1999 • 133 citations

The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

1996 • 132 citations

Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells.

1994 • 130 citations

Extrathymic T cell differentiation

1995 • 129 citations

The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

2003 • 127 citations

Local Hormone Networks and Intestinal T Cell Homeostasis

1997 • 121 citations

Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

1993 • 119 citations

The gut epithelium—A first level lymphoid organ?

1968 • 106 citations

Characterization of T Cell Differentiation in the Murine Gut

2002 • 99 citations

Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent.

1993 • 98 citations

Extrathymic T Cell Differentiation in the Human Intestine Early in Life

1998 • 97 citations

Ontogeny of the Thy-1-, Lyt-2+ murine intestinal intraepithelial lymphocyte. Characterization of a unique population of thymus-independent cytotoxic effector cells in the intestinal mucosa.

1986 • 96 citations

Thymus-Neuroendocrine Interactions in Extrathymic T Cell Development

1994 • 83 citations

Gut intraepithelial lymphocyte development

2002 • 79 citations

Cytotoxic α/β⁺ and γ/δ⁺ T cells in murine intestinal epithelium

1990 • 79 citations

Role of Gut Cryptopatches in Early Extrathymic Maturation of Intestinal Intraepithelial T Cells

2000 • 75 citations

The expansion and selection of T cell receptor αβ intestinal intraepithelial T cell clones

1996 • 67 citations

Detection and characterization of cytotoxic T lymphocyte precursors in the murine intestinal intraepithelial leukocyte population.

1986 • 65 citations

High frequency of CD8αα homodimer‐bearing T cells in human fetal intestine

1994 • 63 citations

Intestinal Cryptopatch Formation in Mice Requires Lymphotoxin α and the Lymphotoxin β Receptor

2004 • 63 citations

Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

1996 • 62 citations

RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation

1995 • 57 citations

Progenies of fetal thymocytes are the major source of CD4⁻CD8⁺ αα intestinal intraepithelial lymphocytes early in ontogeny

1994 • 52 citations

Intestinal γδ T Cells Develop in Mice Lacking Thymus, All Lymph Nodes, Peyer’s Patches, and Isolated Lymphoid Follicles

2005 • 50 citations

Low level of mixing of partner cells seen in extrathymic T cells in the liver and intestine of parabiotic mice: its biological implication

1998 • 48 citations

Complementary Roles for CD19 and Bruton’s Tyrosine Kinase in B Lymphocyte Signal Transduction

2002 • 47 citations

Diversity, Development, Ligands, and Probable Functions of T Cells

1989 • 47 citations

Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine.

1995 • 39 citations

Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease

1990 • 37 citations

Extrathymic Hemopoietic Progenitors Committed to T Cell Differentiation in the Adult Mouse

2005 • 34 citations

Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage

1998 • 34 citations

Extrathymic origin of V_γ1/V_δ6 T cells in the skin

1992 • 31 citations

The early appearance of specific cytotoxic T cells in murine gut mucosa.

1980 • 30 citations

Did the first adaptive immunity evolve in the gut of ancient jawed fish?

1998 • 29 citations

TCR expression in human fetal intestine and identification of an early T cell receptor beta-chain transcript.

1997 • 27 citations

Functional T cell receptor δ chain gene messages in athymic nude mice

1988 • 26 citations

A Gnotobiotic Transgenic Mouse Model for Studying Interactions between Small Intestinal Enterocytes and Intraepithelial Lymphocytes

2002 • 25 citations

Control of thymus‐independent intestinal intraepithelial lymphocytes by β2‐microglobulin

1995 • 24 citations

Identification and characterization of novel gut-associated lymphoid tissues in rat small intestine

2005 • 19 citations

Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes.

1986 • 19 citations

Evidence for the Extrathymic Origin of Intestinal TCRγδ+ T Cells in Normal Rats and for an Impairment of This Differentiation Pathway in BB Rats

2002 • 18 citations

The Majority of Lymphocytes in the Bone Marrow, Thymus and Extrathymic T Cells in the Liver Are Generated In Situ from Their Own Preexisting Precursors

1999 • 16 citations

Speculation on the lineage relationships among CD4−8+gut-derived T cells and their role(s)

1999 • 15 citations

T Cells in Cryptopatch Aggregates Share TCR γ Variable Region Junctional Sequences with γδ T Cells in the Small Intestinal Epithelium of Mice

2006 • 12 citations

Thymus-Independent Development of Gut T Cells

1998 • 11 citations

Ultrastructural and time-lapse observations of intraepithelial lymphocytes in the small intestine of the guinea pig: their possible role in the removal of effete enterocytes

1995 • 10 citations

Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes

2005 • 7 citations