Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Journey through the thymus: stromal guides for T-cell development and selection

2006 • 690 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

The role of BH3-only proteins in the immune system

2005 • 608 citations

Positive selection of lymphocytes

1994 • 563 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

Regulation of CD8 ⁺ T Cell Development by Thymus-Specific Proteasomes

2007 • 528 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

2008 • 500 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Effector CD4⁺ and CD8⁺ T‐cell mechanisms in the control of respiratory virus infections

1997 • 430 citations

Making sense of mass destruction: quantitating MHC class I antigen presentation

2003 • 426 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

2008 • 405 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

How the T Cell Repertoire Becomes Peptide and MHC Specific

2005 • 310 citations

Peptide Diffusion, Protection, and Degradation in Nuclear and Cytoplasmic Compartments before Antigen Presentation by MHC Class I

2003 • 298 citations

CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance

2006 • 294 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Developmental Status and Reconstitution Potential of Subpopulations of Murine Thymocytes

1988 • 211 citations

Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries

1997 • 204 citations

Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain

2002 • 186 citations

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

2008 • 164 citations

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

2007 • 164 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Positive selection of thymocytes bearing αβ T cell receptors

1997 • 124 citations

The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.

1991 • 122 citations

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

2009 • 120 citations

An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

2005 • 119 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Thymocyte-Thymocyte Interaction for Efficient Positive Selection and Maturation of CD4 T Cells

2005 • 110 citations

Thymus‐specific serine protease regulates positive selection of a subset of CD4⁺ thymocytes

2009 • 107 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

CD4+T Cells Are Ineffective in Clearing a Pulmonary Infection with Influenza Type A Virus in the Absence of B Cells

1997 • 87 citations

On the role of thymic epithelium vs. bone marrow-derived cells in repertoire selection of T cells

1999 • 83 citations

Early establishment of diverse T cell receptor profiles for influenza-specific CD8⁺CD62L^himemory T cells

2006 • 83 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Fibroblasts can induce thymocyte positive selection in vivo.

1993 • 73 citations

The why and how of thymocyte negative selection

2006 • 72 citations

Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8 ⁺ T cells expressing the same or different T cell receptors

2004 • 69 citations

Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation

1995 • 61 citations

How a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptide

2008 • 49 citations

Noninvasive Intravital Imaging of Thymocyte Dynamics in Medaka

2007 • 44 citations

Peripheral T Lymphocytes Recirculating Back into the Thymus Can Mediate Thymocyte Positive Selection

2008 • 42 citations

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

2003 • 41 citations

Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

1999 • 38 citations

A Detailed Analysis of the Murine TAP Transporter Substrate Specificity

2008 • 38 citations

An In Vivo Cytotoxicity Threshold for Influenza A Virus-Specific Effector and Memory CD8+ T Cells

2007 • 37 citations

Modest cortex and promiscuous medulla for thymic repertoire formation

2008 • 34 citations

Role of Self Antigens in the Selection of the Developing T Cell Repertoire

1986 • 30 citations

Development of T-Lymphocytes in Mouse Fetal Thymus Organ Culture

2004 • 29 citations

Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains

2007 • 23 citations

Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide

2001 • 19 citations

Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide

2001 • 17 citations

T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition

2008 • 16 citations

The Role of Fibroblasts in Thymocyte-Positive Selection

2002 • 12 citations