Self-Reactive T Cells Selected on Thymic Cortical Epithelium Are Polyclonal and Are Pathogenic In Vivo

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats.

1996 • 795 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

1983 • 285 citations

A systemic lupus erythematosus (SLE)‐like disease in mice induced by abnormal T‐B cell cooperation. Preferential formation of autoantibodies characteristic of SLE

1982 • 267 citations

Identity of cells that imprint H–2-restricted T-cell specificity in the thymus

1986 • 267 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Antinuclear Autoantibodies and Lupus Nephritis in Transgenic Mice Expressing Interferon γ in the Epidermis

1997 • 140 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Autoantibodies in chronic graft versus host result from cognate T-B interactions.

1990 • 133 citations

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation.

1983 • 132 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.

1983 • 118 citations

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

1997 • 116 citations

Two subsets of epithelial cells in the thymic medulla.

1992 • 116 citations

Antigen presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen

1997 • 109 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Post-thymectomy autoimmunity: abnormal T-cell homeostasis

1995 • 100 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen.

1997 • 93 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16

1997 • 83 citations

Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex. VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E.

1982 • 81 citations

Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. VII. Immune-complex glomerulonephritis.

1983 • 80 citations

Pathogenesis of post-thymectomy autoimmunity. Role of syngeneic MLR-reactive T cells.

1995 • 77 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

IMMUNE MECHANISMS IN CYCLOSPORINE-INDUCED SYNGENEIC GRAFT-VERSUS-HOST DISEASE

1989 • 67 citations

Requirements for the induction and adoptive transfer of cyclosporine-induced syngeneic graft-versus-host disease.

1989 • 65 citations

Thymic epithelium tolerizes for histocompatibility antigens

1990 • 53 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

1996 • 47 citations

Mice Expressing the E7 Oncogene of HPV16 in Epithelium Show Central Tolerance, and Evidence of Peripheral Anergising Tolerance, to E7-Encoded Cytotoxic T-Lymphocyte Epitopes

1998 • 44 citations

Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes

1998 • 42 citations

In vitro negative selection of αβ T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells

1993 • 38 citations

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

1997 • 34 citations

Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis

1993 • 21 citations

Immune complex glomerulonephritis

1998 • 17 citations

Quantitative Analysis of the Efficiency of Clonal Deletion in the Thymus

1993 • 16 citations