Aire regulates negative selection of organ-specific T cells

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Regulatory T Cells

2000 • 1,827 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

T Cell Anergy

2003 • 1,418 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

2002 • 558 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Autoimmune Polyglandular Syndrome Type 1

1998 • 422 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Mutations in the AIRE Gene: Effects on Subcellular Location and Transactivation Function of the Autoimmune Polyendocrinopathy-Candidiasis–Ectodermal Dystrophy Protein

2000 • 358 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen

2001 • 220 citations

Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus

2002 • 218 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

A Range of CD4 T Cell Tolerance: Partial Inactivation to Organ-Specific Antigen Allows Nondestructive Thyroiditis or Insulitis

1997 • 178 citations

Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells

2000 • 173 citations

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

1998 • 164 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

2000 • 158 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

2002 • 140 citations

Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells

1996 • 111 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

Self-reactive B Cells Are Not Eliminated or Inactivated by Autoantigen Expressed on Thyroid Epithelial Cells

1997 • 70 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

Regulatory function ofin vivoanergized CD4⁺T cells

2001 • 63 citations

Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein

1999 • 44 citations

Some quantitative aspects of T‐cell repertoire selection: the requirement for regulatory T cells

2001 • 43 citations

Tolerance induction to self antigens by peripheral dendritic cells

2002 • 21 citations