The Role of Excitotoxicity in Neurodegenerative Disease

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

1994 • 2,067 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Apoptosis in the nervous system

2000 • 1,850 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

The AIDS dementia complex: I. Clinical features

1986 • 1,679 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

The AIDS Dementia Complex

1988 • 1,387 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Kainic acid as a tool in neurobiology

1978 • 1,314 citations

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 • 1,313 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

Dose-ranging study of riluzole in amyotrophic lateral sclerosis

1996 • 1,248 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1995 • 1,239 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1995 • 1,124 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Induction of reproducible brain infarction by photochemically initiated thrombosis

1985 • 1,092 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

1993 • 1,084 citations

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

1992 • 1,077 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

1993 • 978 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

Neuropharmacology of quinolinic and kynurenic acids.

1993 • 920 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1995 • 843 citations

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

1996 • 835 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

1984 • 824 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1995 • 774 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 • 736 citations

Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS

1981 • 728 citations

An Outbreak of Toxic Encephalopathy Caused by Eating Mussels Contaminated with Domoic Acid

1990 • 726 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Developmental changes in distribution of NMDA receptor channel subunit mRNAs

1992 • 718 citations

Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh

1995 • 705 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Anatomic and Disease Specificity of NADH CoQ₁ Reductase (Complex I) Deficiency in Parkinson's Disease

1990 • 676 citations

Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis

1994 • 675 citations

Metabolism and role of glutamate in mammalian brain

1990 • 669 citations

Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression

1994 • 661 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

1996 • 654 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

1995 • 646 citations

Cloning of a novel glutamate receptor subunit, GluR5: Expression in the nervous system during development

1990 • 646 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice

1995 • 625 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

In situ injection of kainic acid: A new method for selectively lesioning neuronal cell bodies while sparing axons of passage

1978 • 599 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties

1990 • 581 citations

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A

1993 • 581 citations

AMPA glutamate receptor subunits are differentially distributed in rat brain

1993 • 574 citations

Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block

1995 • 571 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing

1991 • 560 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels

1990 • 555 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

1990 • 553 citations

Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons

1997 • 551 citations

Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

1997 • 549 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits

1992 • 537 citations

Focal seizures due to chronic localized encephalitis

1958 • 528 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

AMPA receptor subunits expressed by single purkinje cells

1992 • 524 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1997 • 513 citations

Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain.

1992 • 505 citations

Nitric Oxide in the Nervous System

1995 • 503 citations

Clinical Experience With Excitatory Amino Acid Antagonist Drugs

1995 • 499 citations

Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

1990 • 498 citations

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1991 • 497 citations

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

1994 • 496 citations

Neurodegenerative Diseases

1994 • 492 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice

1996 • 486 citations

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1990 • 477 citations

3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin

1991 • 476 citations

Evidence for irnnairment of energy metabofism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1993 • 471 citations

Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate

1969 • 471 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

1995 • 471 citations

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

1981 • 468 citations

Neurotoxicity of excitatory amino acids

1990 • 466 citations

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1997 • 465 citations

A complex mosaic of high-affinity kainate receptors in rat brain

1993 • 464 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

AMPA and kainate receptors

1995 • 460 citations

Schizophrenia: Some Current Neurochemical Approaches

1983 • 459 citations

Selective modulation of NMDA responses by reduction and oxidation

1989 • 459 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

Alternatively spliced isoforms of the NMDARI receptor subunit

1995 • 450 citations

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1992 • 450 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents

1993 • 440 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

1996 • 437 citations

The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray

1993 • 435 citations

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH

1996 • 435 citations

An [Na+ + K+]coupledl-glutamate transporter purified from rat brain is located in glial cell processes

1992 • 429 citations

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.

1996 • 420 citations

The synaptic activation of kainate receptors

1997 • 417 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

Acidic amino acids with strong excitatory actions on mammalian neurones

1963 • 415 citations

Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells

1992 • 413 citations

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

1997 • 413 citations

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

1992 • 412 citations

Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

1995 • 411 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.

1994 • 397 citations

Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity

1991 • 397 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

1996 • 383 citations

Mechanisms of excitotoxicity in neurologic diseases

1992 • 382 citations

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

1987 • 380 citations

Cloning of a putative glutamate receptor: A low affinity kainate-binding subunit

1992 • 379 citations

A potential role for excitotoxins in the pathophysiology of spinal cord injury

1988 • 377 citations

Peroxynitrite Inhibits Glutamate Transporter Subtypes

1996 • 375 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA

1986 • 373 citations

Intracellular spermine confers rectification on rat calcium‐permeable AMPA and kainate receptors.

1995 • 369 citations

Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro

1996 • 368 citations

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

1995 • 366 citations

Noncompetitive excitatory amino acid receptor antagonists

1990 • 361 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

1993 • 359 citations

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1989 • 359 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Subunit composition at the single-cell level explains functional properties of a glutamate-gated channel

1994 • 351 citations

Protein kinase C modulation of NMDA currents: an important link for LTP induction

1992 • 350 citations

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.

1993 • 348 citations

BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

1992 • 341 citations

Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum

1997 • 339 citations

A glutamate receptor channel with high affinity for domoate and kainate.

1992 • 336 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Calcium Entry Through Kainate Receptors and Resulting Potassium-Channel Blockade in Bergmann Glial Cells

1992 • 334 citations

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1978 • 330 citations

The rat delta‐1 and delta‐2 subunits extend the excitatory amino acid receptor family

1993 • 330 citations

NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release

1995 • 319 citations

NMDA receptors: from genes to channels

1996 • 319 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

1997 • 317 citations

Nitric oxide in excitable tissues: physiological roles and disease.

1997 • 312 citations

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

1990 • 312 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

Quinolinic acid and other kynurenines in the central nervous system

1985 • 311 citations

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

1981 • 307 citations

Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.

1987 • 303 citations

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

1990 • 303 citations

Abnormal glutamate metabolism in amyotrophic lateral sclerosis

1987 • 302 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

Synaptic signaling by nitric oxide

1997 • 299 citations

Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission.

1990 • 298 citations

N‐Acetylaspartylglutamate Selectively Activates mGluR3 Receptors in Transfected Cells

1997 • 295 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

Selective Expression of the Glutamate Receptor Channel δ2 Subunit in Cerebellar Purkinje Cells

1993 • 287 citations

Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

1982 • 285 citations

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

1995 • 283 citations

Differential Localization of δ Glutamate Receptors in the Rat Cerebellum: Coexpression with AMPA Receptors in Parallel Fiber–Spine Synapses and Absence from Climbing Fiber–Spine Synapses

1997 • 280 citations

Alteration in extracellular amino acids after traumatic spinal cord injury

1990 • 280 citations

Parvalbumin and calbindin D‐28k in the human motor system and in motor neuron disease

1993 • 279 citations

Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion.

1990 • 276 citations

Block of native Ca(2+)‐permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification.

1995 • 276 citations

Toxicity of cycads

1963 • 275 citations

Transient Formation of Superoxide Radicals in Polyunsaturated Fatty Acid‐Induced Brain Swelling

1980 • 267 citations

Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features.

1993 • 267 citations

Chemical Excitation of Spinal Neurones

1959 • 266 citations

CSF and Plasma Amino Acid Levels in Motor Neuron Disease: Elevation of CSF Glutamate in a Subset of Patients

1995 • 264 citations

The antagonism of amino acid-induced excitation of spinal neurones in the cat

1979 • 259 citations

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine‐depleted rats and MPTP‐treated monkeys

1991 • 258 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

Neuronal Vacuolization and Necrosis Induced by the Noncompetitive N-methyl-d-aspartate (NMDA) Antagonist MK(+)801 (Dizocilpine Maleate): A Light and Electron Microscopic Evaluation of the Rat Retrosplenial Cortex

1993 • 257 citations

Impaired parallel fiber-->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta2 subunit.

1997 • 257 citations

The Isolation and Characterization of β-N-Oxalyl-L-α,β-Diaminopropionic Acid: A Neurotoxin from the Seeds of Lathyrus sativus^*

1964 • 257 citations

Na+ channels as targets for neuroprotective drugs

1995 • 255 citations

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

1993 • 254 citations

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

1993 • 254 citations

Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors

1991 • 252 citations

Mechanisms of Cell Death Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Acute Excitotoxic Necrosis and Delayed Apoptosis

1997 • 250 citations

Human microglia convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1996 • 248 citations

Models of neuronal injury in AIDS: another role for the NMDA receptor?

1992 • 247 citations

Impaired Parallel Fiber→Purkinje Cell Synapse Stabilization during Cerebellar Development of Mutant Mice Lacking the Glutamate Receptor δ2 Subunit

1997 • 247 citations

Excitotoxin Lesions in Primates as a Model for Huntington's Disease: Histopathologic and Neurochemical Characterization

1993 • 245 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

The primary afferent depolarizing action of kainate in the rat

1986 • 244 citations

A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.

1993 • 243 citations

The N-methyl-D-aspartate antagonist, MK-801, fails to protect against neuronal damage caused by transient, severe forebrain ischemia in adult rats

1991 • 239 citations

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1996 • 237 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation.

1978 • 236 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices

1989 • 234 citations

The TIPS/TINS Lecture: The molecular biology of mammalian glutamate receptor channels

1993 • 233 citations

The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.

1993 • 230 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: A type of hypoxic (energy deficient) brain damage

1987 • 229 citations

Ca(2+)‐permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.

1995 • 225 citations

Temporal lobe epilepsy caused by domoic acid intoxication: Evidence for glutamate receptor–mediated excitotoxicity in humans

1995 • 224 citations

Functional kainate-selective glutamate receptors in cultured hippocampal neurons.

1993 • 224 citations

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

1991 • 219 citations

Neuroprotective Strategies in a Model of Chronic Glutamate‐Mediated Motor Neuron Toxicity

1995 • 218 citations

Disappearance of high‐incidence amyotrophic lateral sclerosis and parkinsonism‐dementia on Guam

1985 • 217 citations

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation

1988 • 216 citations

Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site

1995 • 214 citations

Calcium‐permeable α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis

1997 • 210 citations

Toxic Constituents of Plant Foodstuffs

1970 • 210 citations

The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis

1988 • 210 citations

Permeation of Calcium Ions Through Non-NMDA Glutamate Channels in Retinal Bipolar Cells

1991 • 209 citations

Epidemiologic Investigations of Amyotrophic Lateral Sclerosis

1954 • 209 citations

Neurotoxicity ofβ-N-methylamino-l-alanine (BMAA) andβ-N-oxalylamino-l-alamine (BOAA) on cultured cortical neurons

1989 • 206 citations

Riluzole

1996 • 204 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

Characterization and localization of the Huntington disease gene product

1993 • 202 citations

The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat

1992 • 201 citations

Multiple effects of spermine on N‐methyl‐D‐aspartic acid receptor responses of rat cultured hippocampal neurones.

1993 • 199 citations

Beta- N -Methylamino-L-Alanine Neurotoxicity: Requirement for Bicarbonate as a Cofactor

1988 • 199 citations

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

1990 • 198 citations

Lubeluzole Treatment of Acute Ischemic Stroke

1997 • 197 citations

Plasmapheresis in Rasmussen's encephalitis

1996 • 197 citations

Safety, Tolerability, and Pharmacokinetics of the N -Methyl- <scp>d</scp> -Aspartate Antagonist Dextrorphan in Patients With Acute Stroke

1995 • 194 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells.

1994 • 194 citations

Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells

1986 • 193 citations

Epidemiologic Investigations of Amyotrophic Lateral Sclerosis

1954 • 193 citations

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

1992 • 193 citations

Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity

1992 • 193 citations

Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro : Stereospecificity and Selectivity Profiles

1996 • 192 citations

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h

1993 • 192 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

1995 • 190 citations

Preferential co-assembly of recombinant NMDA receptors composed of three different subunits

1993 • 190 citations

Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

1989 • 190 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

1988 • 189 citations

Rat GluR7 and a Carboxy-Terminal Splice Variant, GluR7b, Are Functional Kainate Receptor Subunits with a Low Sensitivity to Glutamate

1997 • 189 citations

Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors

1993 • 189 citations

The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

1991 • 188 citations

Emerging treatments for stroke in humans

1996 • 188 citations

2‐Amino‐3‐(methylamino)‐propanoic acid (BMAA) in cycad flour

1990 • 187 citations

Termination of Acute Stroke Studies Involving Selfotel Treatment

1997 • 187 citations

A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

1993 • 186 citations

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

1988 • 186 citations

Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.

1991 • 186 citations

Argiotoxin detects molecular differences in AMPA receptor channels

1993 • 186 citations

Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

1994 • 185 citations

Lamotrigine

1992 • 184 citations

The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model

1992 • 184 citations

Effects of theN-Methyl-<scp>d</scp>-Aspartate Receptor Blocker MK-801 on Neurologic Function After Experimental Brain Injury

1989 • 183 citations

Glutamate receptor subunit 2-selective antibody shows a differential distribution of calcium-impermeable AMPA receptors among populations of neurons

1997 • 183 citations

High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture

1986 • 181 citations

NMDA Antagonists as Neurotherapeutic Drugs, Psychotogens, Neurotoxins, and Research Tools for Studying Schizophrenia

1995 • 181 citations

Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines.

1995 • 180 citations

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

1993 • 180 citations

Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.

1990 • 179 citations

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis

1998 • 178 citations

Delayed Treatment with AMPA, but Not NMDA, Antagonists Reduces Neocortical Infarction

1994 • 178 citations

‘Lurcher’, a new gene in linkage group XI of the house mouse

1960 • 177 citations

Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.

1993 • 177 citations

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

1992 • 174 citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1995 • 174 citations

The Nagging Question of the Function ofN-Acetylaspartylglutamate

1997 • 173 citations

Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins.

1996 • 172 citations

Control of NMDA Receptor Activation by a Glycine Transporter Co-Expressed inXenopusOocytes

1997 • 170 citations

Glutamate neurotoxicity in spinal cord cell culture

1991 • 169 citations

d-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed inXenopus oocytes

1990 • 168 citations

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

1992 • 167 citations

N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents.

1994 • 166 citations

Spider toxins as tools for dissecting elements of excitatory amino acid transmission

1988 • 165 citations

Excitatory amino acid receptors of the retina: diversity of subtypes and conductance mechanisms

1986 • 165 citations

Behavioral effects of MK-801 in the rat

1990 • 164 citations

Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid

1990 • 163 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells

1994 • 163 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Polyamine Regulation of N-Methyl-D-Aspartate Receptor Channels

1995 • 162 citations

Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage.

1996 • 162 citations

Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor

1996 • 159 citations

Selective RNA editing and subunit assembly of native glutamate receptors

1994 • 158 citations

Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina.

1990 • 158 citations

Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition.

1991 • 157 citations

Get receptive to metabotropic glutamate receptors

1995 • 157 citations

Lubeluzole in Acute Ischemic Stroke

1996 • 157 citations

Neurotoxicity at the N‐Methyl‐D‐Aspartate Receptor in Energy‐Compromised Neurons An Hypothesis for Cell Death in Aging and Disease

1989 • 157 citations

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.

1993 • 156 citations

Modulation of channel function by polyamines

1996 • 156 citations

Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo

1992 • 156 citations

N-Methyl-d-Aspartate Antagonist MK801 Improves Outcome Following Traumatic Spinal Cord Injury in Rats: Behavioral, Anatomic, and Neurochemical Studies

1988 • 155 citations

Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

1995 • 155 citations

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

1995 • 155 citations

MK‐801 Prevents 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinsonism in Primates

1992 • 155 citations

Specific antagonism of excitotoxic action of ‘uncommon’ amino acids assayed in organotypic mouse cortical cultures

1987 • 154 citations

Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?

1990 • 154 citations

Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.

1990 • 154 citations

Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

1989 • 154 citations

Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis

1996 • 153 citations

Memantine prevents HIV coat protein‐induced neuronal injury in vitro

1992 • 153 citations

Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia

1992 • 153 citations

Glutamate receptors of the kainate type and synaptic transmission

1997 • 152 citations

Cortical neurons containing calretinin are selectively resistant to calcium overload and excitotoxicity in vitro

1994 • 152 citations

In Vitro Release of Endogenous Excitatory Sulfur‐Containing Amino Acids from Various Rat Brain Regions

1986 • 151 citations

Motor Neuron Disease (Amyotrophic Lateral Sclerosis)

1991 • 151 citations

Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120

1992 • 149 citations

Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist

1992 • 148 citations

Amyotrophic lateral sclerosis and parkinson's disease complex on Guam linked to an environmental neurotoxin

1988 • 148 citations

Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA₁ Neuronal Injury

1993 • 148 citations

Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons.

1996 • 145 citations

Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat.

1992 • 145 citations

Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family

1992 • 145 citations

Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466

1989 • 144 citations

Activation and Desensitization of Hippocampal Kainate Receptors

1997 • 144 citations

Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.

1989 • 143 citations

Metabotropic Glutamate Receptors

2017 • 143 citations

Neurochemical and Behavioral Aspects of Lamotrigine

1991 • 142 citations

Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina

1991 • 142 citations

Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.

1992 • 142 citations

Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.

1979 • 141 citations

Organisation behaviour

1975 • 141 citations

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine

1996 • 139 citations

Putative acidic amino acid transmitters in the cerebellum I. Depolarization-induced release

1982 • 137 citations

NITRIC OXIDE: ROLE IN NEUROTOXICITY

1995 • 137 citations

Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

1992 • 137 citations

Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site.

1995 • 137 citations

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures

1996 • 136 citations

New models of focal cerebral ischaemia.

1992 • 135 citations

High‐affinity kainate a domoate receptors in rat brain

1992 • 135 citations

Neurodegenerative disorders of the western pacific: the search for mechanisms of pathogenesis

1986 • 134 citations

HIV envelope protein-induced neuronal damage and retardation of behavioral development in rat neonates

1993 • 132 citations

Neuroprotective Properties of the Novel Antiepileptic Lamotrigine in a Gerbil Model of Global Cerebral Ischemia

1995 • 132 citations

Glutamate Neurotoxicity in Rat Cerebellar Granule Cells: A Major Role for Xanthine Oxidase in Oxygen Radical Formation

1997 • 131 citations

Subunit Composition, Kinetic, and Permeation Properties of AMPA Receptors in Single Neocortical Nonpyramidal Cells

1997 • 131 citations

Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists

1988 • 130 citations

7‐クロルキヌレン酸はN‐メチル‐D‐アスパラギン酸受容体複合体のグリシン調節部位での選択的きっ抗物質である

1988 • 130 citations

Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action

1994 • 129 citations

Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury

1993 • 128 citations

HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site

1989 • 128 citations

Domoic Acid Neurotoxicity in Cultured Cerebellar Granule Neurons Is Mediated Predominantly by NMDA Receptors that Are Activated as a Consequence of Excitatory Amino Acid Release

1997 • 128 citations

Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.

1991 • 127 citations

Involvement of lipid peroxidation in CNS injury.

1992 • 125 citations

N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.

1983 • 124 citations

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.

1994 • 122 citations

BASAL GANGLIA DEGENERATION, MYELIN ALTERATIONS, AND ENZYME INHIBITION INDUCED IN MICE BY THE PLANT TOXIN 3‐NITROPROPANOIC ACID

1982 • 121 citations

Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study.

1992 • 121 citations

Apoptosis in the Nervous System: Morphological Features, Methods, Pathology, and Prevention.

1995 • 121 citations

The Sodium Channel Blocker and Glutamate Release Inhibitor BW1003C87 and Magnesium Attenuate Regional Cerebral Edema Following Experimental Brain Injury in the Rat

1995 • 120 citations

HIV‐1 Envelope Proteins gp120 and gp160 Potentiate NMDA‐induced [Ca²⁺]_i Increase, Alter [Ca²⁺]_i Homeostasis and Induce Neurotoxicity in Human Embryonic Neurons

1995 • 120 citations

MK‐801 Fails to Protect Against the Dopaminergic Neuropathology Produced by Systemic 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mice or Intranigral 1‐Methyl‐4‐Phenylpyridinium in Rats

1992 • 120 citations

The lurcher gene induces apoptotic death in cerebellar Purkinje cells

1995 • 119 citations

A single amino acid determines the subunit-specific spider toxin block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.

1993 • 118 citations

Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders

1993 • 118 citations

Brain glutamate deficiency in amyotrophic lateral sclerosis

1987 • 118 citations

Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists

1987 • 117 citations

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

1991 • 117 citations

Characterization of the Excitotoxic Potential of the Reversible Succinate Dehydrogenase Inhibitor Malonate

1995 • 117 citations

Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents

1994 • 116 citations

(2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors.

1997 • 116 citations

Felbamate

1993 • 116 citations

Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat

1990 • 115 citations

Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

1996 • 114 citations

Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: Evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALS

1995 • 114 citations

Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine

1992 • 114 citations

Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

1993 • 113 citations

Effects of cortical ablation on the neurotoxicity and receptor binding of kainic acid in striatum

1979 • 113 citations

Riluzole

1996 • 112 citations

Brain Quinolinic Acid in Huntington's Disease

1988 • 111 citations

Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia

1996 • 111 citations

1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway

1986 • 111 citations

Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex

1990 • 110 citations

Progressive slowing of reaction time and increasing cerebrospinal fluid concentrations of quinolinic acid in HIV-infected individuals

1992 • 110 citations

CP-101,606, a potent neuroprotectant selective for forebrain neurons

1997 • 109 citations

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87

1992 • 107 citations

Human immunodeficiency virus type 1 infection of the brain

1993 • 106 citations

Immunoprecipitation, immunoblotting, and immunocytochemistry studies suggest that glutamate receptor delta subunits form novel postsynaptic receptor complexes

1995 • 106 citations

The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.

1994 • 106 citations

Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

1988 • 105 citations

Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors.

1995 • 105 citations

Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings

1994 • 105 citations

Emerging perspectives on the mechanism of action of gabapentin.

1994 • 105 citations

Quinoxaline derivatives are high-affinity antagonists of the NMDA receptor-associated glycine sites

1989 • 105 citations

Spider toxins affecting glutamate receptors: Polyamines in therapeutic neurochemistry

1991 • 103 citations

A controlled trial of remacemide hydrochloride in Huntington's disease

1996 • 103 citations

Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.

1993 • 103 citations

Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss

1993 • 103 citations

Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur-Containing Amino Acids

1987 • 103 citations

Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient

1994 • 101 citations

The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid

1995 • 101 citations

Mechanisms of action of new antiepileptic drugs

1997 • 100 citations

The Effects of Dizocilpine Maleate (MK-801), an Antagonist of the N-Methyl-D-Aspartate Receptor, on Neurologic Recovery and Histopathology following Complete Cerebral Ischemia in Primates

1990 • 100 citations

Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons

1994 • 99 citations

Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

1991 • 98 citations

Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization

1993 • 97 citations

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

1996 • 97 citations

HU-211, a Novel Noncompetitive N -Methyl- <scp>d-</scp> Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat

1995 • 97 citations

Molecular genetic basis of familial ALS

1996 • 97 citations

Excitotoxicity and motor neurone disease: A review of the evidence

1994 • 96 citations

Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture

1990 • 96 citations

Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures

1995 • 96 citations

Stereospecific acute neuronotoxicity of ‘uncommon’ plant amino acids linked to human motor-system diseases

1987 • 96 citations

Domoic and quisqualic acids as potent amino acid excitants of frog and rat spinal neurones

1975 • 96 citations

Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: neurotransmitters modulate the open probability

1995 • 95 citations

Role of the β-amyloid precursor protein in Alzheimer's disease

1994 • 95 citations

2,3‐Benzodiazepines (GYKI 52466 and Analogs): Negative Allosteric Modulators of AMPA Receptors

1996 • 95 citations

Cell surface expression of the human N-methyl-d-aspartate receptor subunit 1a requires the co-expression of the NR2A subunit in transfected cells

1996 • 94 citations

Pentameric subunit stoichiometry of a neuronal glutamate receptor.

1996 • 94 citations

β‐N‐Oxalylamino‐L‐Alanine Action on Glutamate Receptors

1989 • 94 citations

Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord

1989 • 94 citations

HIV-1 Associated Dementia: Clinical Features and Pathogenesis

1995 • 94 citations

The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia

1990 • 93 citations

Lathyrism: a neurotoxic disease.

1983 • 93 citations

Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin₆₃₆

1989 • 93 citations

Anti-Glutamate Therapy in Amyotrophic Lateral Sclerosis: A Trial Using Lamotrigine

1993 • 92 citations

Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study

1995 • 91 citations

Antioxidant treatment protects striatal neurons against excitotoxic insults

1996 • 91 citations

NMDA antagonists partially protect against MPTP induced neurotoxicity in mice

1993 • 90 citations

Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels

1994 • 89 citations

HIV-related neuronal injury

1994 • 89 citations

Lack of effect of L‐687,414 ((+)‐cis‐4‐methyl‐HA‐966)₅ an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology

1993 • 89 citations

Voltage‐dependent blockage of Ca(2+)‐permeable AMPA receptors by joro spider toxin in cultured rat hippocampal neurones.

1996 • 89 citations

Excitatory amino acids and synaptic transmission

1992 • 88 citations

The Glycine Antagonist GV150526 Protects Somatosensory Evoked Potentials and Reduces the Infarct Area in the MCAo Model of Focal Ischemia in the Rat

1997 • 88 citations

In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.

1995 • 88 citations

A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding

1993 • 88 citations

Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18h) therapeutic window

1993 • 87 citations

Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices

1981 • 86 citations

Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats.

1996 • 86 citations

The Neurobiology of N-Acetylasparty

1988 • 85 citations

Molecular Cloning of a Peptidase Against N‐Acetylaspartylglutamate from a Rat Hippocampal cDNA Library

1997 • 83 citations

Effects of 3‐acetylpyridine on several putative neurotransmitter amino acids in the cerebellum and medulla of the rat¹

1977 • 83 citations

The Regional Distribution of N‐Acetylaspartylglutamate (NAAG) and Peptidase Activity Against NAAG in the Rat Nervous System

1994 • 83 citations

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates

1993 • 82 citations

Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease

1997 • 82 citations

Motoneurons destined to die are rescued by blocking n-methyl-d-aspartate receptors by MK-801

1993 • 80 citations

A gerbil model of cerebral ischemia suitable for drug evaluation.

1980 • 80 citations

Felbamate block of the N-methyl-D-aspartate receptor.

1995 • 80 citations

YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.

1996 • 80 citations

Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes

1994 • 80 citations

Synapse‐selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.

1997 • 80 citations

Fasting plasma and CSF amino acid levels in amyotrophic lateral sclerosis: a subtype analysis

2009 • 79 citations

Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism

1993 • 78 citations

Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.

1996 • 78 citations

Neuroprotection of Lubeluzole Is Mediated Through the Signal Transduction Pathways of Nitric Oxide

1997 • 77 citations

Light- and electron-microscopic localization of the glutamate receptor channel 62 subunit in the mouse Purkinje cell

1995 • 77 citations

Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey

1989 • 76 citations

Control of 40-Hz firing of reticular thalamic cells by neurotransmitters

1992 • 76 citations

Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats

1997 • 75 citations

Selective degeneration of cerebellar cortical neurons caused by cycad neurotoxin, L‐β‐methylaminoalanine (L‐BMAA), in rats

1990 • 75 citations

The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (MPP+)

1990 • 74 citations

NMDA Receptor Involvement in Toxicity to Dopamine Neurons In Vitro Caused by the Succinate Dehydrogenase Inhibitor 3‐Nitropropionic Acid

1995 • 74 citations

N-Acetylaspartylglutamate catabolism is achieved by an enzyme on the cell surface of neurons and glia

1993 • 73 citations

Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons.

1995 • 73 citations

Toward Understanding the Molecular Pathology of Huntington's Disease

1997 • 72 citations

Pharmacological evidence for L‐aspartate as the neurotransmitter of cerebellar climbing fibres in the guinea‐pig.

1985 • 72 citations

Immunological Detection of the NMDAR1 Glutamate Receptor Subunit Expressed in Human Embryonic Kidney 293 Cells and in Rat Brain

1992 • 71 citations

Spermine mediates inward rectification of Ca2+-permeable AMPA receptor channels

1995 • 71 citations

Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist

1989 • 70 citations

Phencyclidine

1987 • 70 citations

High‐dose dextromethorphan in amyotrophic lateral sclerosis: Phase I safety and pharmacokinetic studies

1994 • 70 citations

Ultrastructural localization of N-acetylaspartylglutamate in synaptic vesicles of retinal neurons

1988 • 70 citations

Neurochemical and Immunocytochemical Studies on the Distribution of N‐Acetyl‐Aspartylglutamate and N‐Acetyl‐Aspartate in Rat Spinal Cord and Some Peripheral Nervous Tissues

1987 • 70 citations

Calcium directly permeates kainate/alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptors in cultured cerebellar Purkinje neurons.

1992 • 70 citations

Evidence that local non-NMDA receptors contribute to functional deficits in contusive spinal cord injury

1992 • 69 citations

Interactions Between N‐Acetylaspartylglutamate and AMPA, Kainate, and NMDA Binding Sites

1994 • 69 citations

Effect of cyclothiazide on binding properties of AMPA-type glutamate receptors: lack of competition between cyclothiazide and GYKI 52466.

1996 • 68 citations

Recombinant Human NMDA Homomeric NR1 Receptors Expressed in Mammalian Cells Form a High‐Affinity Glycine Antagonist Binding Site

1995 • 68 citations

Evidence for cysteine sulfinate as a neurotransmitter

1982 • 68 citations

Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice

1992 • 68 citations

Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses

1997 • 67 citations

Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655

1993 • 67 citations

Sparing of cholinergic neurons following quinolinic acid lesions of the rat striatum

1988 • 66 citations

Spider toxin blocks excitatory amino acid responses in isolated hippocampal pyramidal neurons

1987 • 65 citations

4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine SiteN-Methyl-<scp>d</scp>-aspartate Antagonists withinVivoActivity

1997 • 65 citations

Calcium‐Dependent Evoked Release of N[³H]Acetylaspartylglutamate from the Optic Pathway

1988 • 64 citations

Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

1994 • 63 citations

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

1992 • 63 citations

[3H]d-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study

1994 • 62 citations

A pilot trial of dextromethorphan in amyotrophic lateral sclerosis.

1993 • 61 citations

N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.

1990 • 61 citations

Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate

1987 • 61 citations

An appraisal of the neurotoxicity of cycad and the etiology of amyotrophic lateral sclerosis on Guam.

1972 • 60 citations

Comparison of the Neuroprotective Effects of the N-Methyl-D-Aspartate Antagonist MK-801 and the Opiate-Receptor Antagonist Nalmefene in Experimental Spinal Cord Ischemia

1990 • 60 citations

Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain

1994 • 59 citations

Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase

1995 • 58 citations

Experimental Neurolathyrism in Monkeys

1967 • 57 citations

Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis

1989 • 57 citations

Altered Na+-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs

1997 • 57 citations

Release of endogenous amino acids, including homocysteic acid and cysteine sulphinic acid, from rat hippocampal slices evoked by electrical stimulation of Schaffer collateral-commissural fibres

1992 • 57 citations

Excitotoxicity in the embryonic chick spinal cord

1991 • 57 citations

Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat

1993 • 56 citations

The transmitter-gated channels: a range of receptor types and structures

1996 • 56 citations

Localization of quinolinic acid metabolizing enzymes in the rat brain. immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase

1988 • 55 citations

Memantine prevents quinolinic acid-induced hippocampal damage

1992 • 55 citations

Exposure to gp120 of HIV‐1 Induces an Increased Release of Arachidonic Acid in Rat Primary Neuronal Cell Culture Followed by NMDA Receptor‐mediated Neurotoxicity

1995 • 54 citations

Pharmacological effects of the non-competitive NMDA antagonist CNS 1102 in normal volunteers.

1994 • 54 citations

Riluzole and experimental parkinsonism

1994 • 54 citations

Identification of a subunit-specific antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate receptor channels.

1993 • 54 citations

Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons

1988 • 53 citations

(+)MK-801 does not prevent MPTP-induced loss of nigral neurons in mice.

1997 • 52 citations

The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease

1994 • 52 citations

Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission

1995 • 52 citations

Effect of Climbing Fiber Deprivation on Release of Endogenous Aspartate, Glutamate, and Homocysteate in Slices of Rat Cerebellar Hemispheres and Vermis

1990 • 51 citations

Stimulation of basal and l-DOPA-induced motor activity by glutamate antagonists in animal models of Parkinson's disease

1997 • 51 citations

SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons

1992 • 50 citations

Treatment of experimental focal ischemia in rats with lubeluzole

1996 • 50 citations

TOXIC AND CARCINOGENIC ALKYLATING AGENTS FROM CYCADS

1969 • 50 citations

Receptor site specificity for the acute effects of β-N-methylamino-alanine in mice

1990 • 50 citations

Comparative Antagonism of Kainate‐activated Kainate and AMPA Receptors in Hippocampal Neurons

1996 • 49 citations

N-methyl-d-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies

1992 • 49 citations

Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats

1995 • 48 citations

Abnormal distribution of phosphorylated neurofilaments in neuronal degeneration induced by kainic acid

1990 • 48 citations

Enhancing the efficacy of thrombolysis by AMPA receptor blockade with NBQX in a rat embolic stroke model

1993 • 46 citations

Acute behavioral effects of MK-801 in the mouse

1996 • 46 citations

Metabotropic glutamate receptors: an original family of G protein‐coupled receptors

1993 • 46 citations

Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation

1995 • 46 citations

Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease

1997 • 46 citations

Plasma amino acid levels in patients with amyotrophic lateral sclerosis

1992 • 45 citations

Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice

1992 • 44 citations

Glutamatergic drugs in Parkinson's disease

1994 • 44 citations

A Controlled One-Year Trial of Dextromethorphan in Amyotrophic Lateral Sclerosis

1996 • 44 citations

Inhibitory Effect of MS-153 on Elevated Brain Glutamate Level Induced by Rat Middle Cerebral Artery Occlusion

1996 • 43 citations

Induction of Neuronal Apoptosis by Excitotoxins Associated with Long‐Lasting Increase of 12‐O‐Tetradecanoylphorbol 13‐Acetate‐Responsive Element‐Binding Activity

1995 • 43 citations

Iodoacetate Produces Striatal Excitotoxic Lesions

1997 • 43 citations

An initial analysis of the regional distribution of excitatory sulphur-containing amino acids in the rat brain

1986 • 42 citations

An Open Label Trial of Dextromethorphan in Huntingtonʼs Disease

1989 • 42 citations

The anticonvulsant and behavioural profile of L‐687,414, a partial agonist acting at the glycine modulatory site on the N‐methyl‐D‐aspartate (NMDA) receptor complex

1994 • 41 citations

Failure of MK-801 to reduce infarct volume in thrombotic middle cerebral artery occlusion in rats.

1993 • 41 citations

Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.

1990 • 41 citations

Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury?

1995 • 41 citations

Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons

1996 • 41 citations

4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex

1990 • 41 citations

Co-agonism in drug-receptor interaction: illustrated by the NMDA receptors

1996 • 40 citations

In vivo protection of striatum from MPP+ neurotoxicity by N-methyl-d-aspartate antagonists

1992 • 40 citations

Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.

1992 • 39 citations

Riluzole Reduces Incidence of Abnormal Movements but Not Striatal Cell Death in a Primate Model of Progressive Striatal Degeneration

1997 • 39 citations

Inhibition of high voltage-activated calcium currents by l-glutamate receptor-mediated calcium influx

1993 • 38 citations

Studies on the etiology and pathogenesis of motor neuron diseases. II.

1988 • 38 citations

Protection With Lubeluzole Against Delayed Ischemic Brain Damage in Rats

1997 • 37 citations

The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures

1992 • 37 citations

Sulphur-containing excitatory amino acids in intercellular communication

1993 • 37 citations

Ibotenic acid stimulates d-[3H]aspartate release from cultured cerebellar granule cells

1989 • 37 citations

Tetrodotoxin blocks HIV coat protein (gp120) toxicity in primary neuronal cultures

1994 • 37 citations

AMPA receptor antagonists and local cerebral glucose utilization in the rat

1994 • 37 citations

Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay

1988 • 36 citations

Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat

1994 • 36 citations

-(S)-Alpha-phenyl-2-pyridine-ethanamine Dihydrochloride-, a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia.

1997 • 36 citations

Neuronal injury evoked by depolarizing agents in rat cortical cultures

1992 • 36 citations

Rasmussenʼs encephalitis

1996 • 36 citations

Riluzole and experimental parkinsonism

1994 • 36 citations

Rasmussen's encephalitis: an autoimmune disorder?

1996 • 35 citations

Effect of optic nerve transection onN-acetylaspartylglutamate immunoreactivity in the primary and accessory optic projection systems in the rat

1991 • 35 citations

Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons

1989 • 35 citations

The Rationale for Glutamate Antagonists in the Treatment of Traumatic Brain Injury

1995 • 34 citations

The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists

1994 • 33 citations

Philanthotoxin blocks quisqualate‐, AMPA‐ and kainate‐, but not NMDA‐, induced excitation of rat brainstem neurones in vivo

1990 • 33 citations

Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures

1997 • 33 citations

Release of N‐Acetylaspartylglutamate from Slices of Rat Cerebellum, Striatum, and Spinal Cord, and the Effect of Climbing Fiber Deprivation

1994 • 32 citations

Comparative neuroprotective effects of pentobarbital, vinpocetine, flunarizine and ifenprodil on ischemic neuronal damage in the gerbil hippocampus

1990 • 32 citations

Lathyrism and western Pacific amyotrophic lateral sclerosis: etiology of short and long latency motor system disorders.

1991 • 30 citations

The isolation of secretin—its chemical and physiological properties

1928 • 30 citations

Distinct effects of ω-toxins and various groups of Ca2+-entry inhibitors on nicotinic acetylcholine receptor and Ca2+ channels of chromaffin cells

1997 • 30 citations

Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes

1997 • 29 citations

Effects of methylazoxymethanol glucoside and methylazoxymethanol acetate on the cerebellum of the postnatal Swiss albino mouse.

1972 • 29 citations

Slow non-NMDA receptor mediated neurotoxicity and amyotrophic lateral sclerosis.

1991 • 26 citations

Neuroprotective Profile of Riluzole in In Vivo Models of Acute Neurodegenerative Diseases

1997 • 25 citations

Amyotrophic lateral sclerosis/parkinsonism-dementia complex in southern Guam: is it disappearing?

1991 • 25 citations

Latest eruptions in metabotropic glutamate receptors

1996 • 25 citations

d-CPPene (SDZ EAA-494)—A Competitive NMDA Antagonist

1997 • 25 citations

A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor

1996 • 25 citations

Quinolinate in Brain and Cerebrospinal Fluid in Rat Models of Congenital Hyperammonemia

1992 • 24 citations

Computer-aided drug design: Methods and applications

1990 • 24 citations

In vitro and in vivo inhibition of N-acetyl-L-aspartyl-L-glutamate catabolism by N-acylated L-glutamate analogs.

1992 • 23 citations

Neuronal damage induced by ß-N-oxalylamino-l-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline

1993 • 23 citations

Selective distribution of N-acetylasparthlglutamate immunoreactivity in the extrapyramidal system of the rat

1989 • 23 citations

Riluzole prevents anoxic injury in cultured cerebellar granule neurons

1993 • 22 citations

Evans blue antagonizes both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates receptor desensitization.

1996 • 22 citations

Effects of depolarizing stimuli on calcium homeostasis in cultured rat motoneurones

1998 • 22 citations

Ca2+ permeable AMPA/kainate channels permit rapid injurious Ca2+ entry

1995 • 21 citations

Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia

1997 • 21 citations

Ibotenate stimulates glutamate release from guinea pig cerebrocortical synaptosomes: inhibition by l-2-amino-4-phosphonobutyrate (l-AP4)

1990 • 21 citations

Carcinogenicity and neurotoxicity of cycasin with sepcial reference to species differences.

1972 • 20 citations

7‐Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures

1992 • 20 citations

2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo

1994 • 20 citations

Lamotrigine--a novel approach.

1994 • 20 citations

Glutamate Antagonists in Amyotrophic Lateral Sclerosis

1996 • 20 citations

¹²⁵I‐Ifenprodil: Synthesis and Characterization of Binding to a Polyamine‐Sensitive Site in Cerebral Cortical Membranes

1993 • 19 citations

Potentiation of MK-801-induced breathing impairment by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline

1994 • 19 citations

Systemic and Cerebral Hemodynamic Responses to the Noncompetitive N-Methyl-D-Aspartate (NMDA) Antagonist CNS 1102

1995 • 19 citations

A Randomized, Double‐Blind, Placebo‐Controlled Ascending Dose Tolerance Study of 619C89 in Acute Stroke

1995 • 19 citations

Pharmacokinetics and Safety of the Novel Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate Receptor Antagonist YM90K in Healthy Men

1997 • 18 citations

Gabapentin : Mechanism of action

1995 • 18 citations

Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative

1994 • 17 citations

Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes

1996 • 17 citations

Characterization of indole-2-carboxylate derivatives as antagonists of N-methyl-D-aspartate receptor activity at the associated glycine recognition site.

1992 • 17 citations

Ion channels activated by quinolinic acid in cultured rat hippocampal neurons

1989 • 16 citations

Intracerebral injection of human immunodeficiency virus type 1 coat glycoprotein GP120 does not produce neurodegeneration in rats

1994 • 16 citations

Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole

1994 • 16 citations

Aminooxyacetic acid produces excitotoxic brain injury in neonatal rats

1993 • 16 citations

Amyotrophic lateral sclerosis cerebrospinal fluid is not toxic to cultured spinal motor neurons

1995 • 16 citations

Kinetic characterization of sulphur-containing excitatory amino acid uptake in primary cultures of neurons and astrocytes

1991 • 14 citations

Accumulation of ³H‐Phosphoinositides Mediated by Muscarinic Receptors in the Developing Chick Retina: Inhibition of Carbachol‐Induced Response by Glutamate Receptors

1995 • 14 citations

An anti-χ-1 antibody recognizes a heavily glycosylated protein in rat brain

1997 • 12 citations

Rasmussen's encephalitis

1997 • 11 citations

N‐Methyl D‐aspartate Receptors

2008 • 9 citations

3-33-01 Lubeluzole in acute ischemic stroke: International trial

1997 • 6 citations

2H-3,4-Dihydro-1,2,4-benzothiadiazine-1, 1-dioxide-3-carboxylic acid derivatives, a novel family of glycine antagonists of the NMDA receptor channel complex

1995 • 4 citations

Deleted Work

1955 • 0 citations