Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A

1993 • 581 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents

1993 • 440 citations

Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate

1993 • 369 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.

1994 • 295 citations

Non-NMDA receptor-mediated neurotoxicity in cortical culture

1990 • 291 citations

Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons

1991 • 263 citations

Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes

1988 • 258 citations

Quisqualate Activates a Rapidly Inactivating High Conductance Ionic Channel in Hippocampal Neurons

1989 • 237 citations

Rapid desensitization of glutamate receptors in vertebrate central neurons.

1988 • 205 citations

The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat

1992 • 201 citations

A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

1993 • 186 citations

The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model

1992 • 184 citations

Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.

1988 • 146 citations

Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat.

1992 • 145 citations

6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor

1994 • 123 citations

AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity

1995 • 111 citations

Quinoxalinediones selectively block quisqualate and kainate receptors and synaptic events in rat neocortex and hippocampus and frog spinal cord in vitro

1988 • 109 citations

N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology.

1989 • 90 citations

Neuroprotective Effect of the AMPA Receptor Antagonist LY-293558 in Focal Cerebral Ischemia in the Cat

1994 • 85 citations

Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes

1986 • 85 citations

YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.

1996 • 80 citations

Cyclothiazide Treatment Unmasks AMPA Excitotoxicity in Rat Primary Hippocampal Cultures

1993 • 67 citations

Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655

1993 • 67 citations

Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons

1990 • 65 citations

Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methylendioxyl-5H-2,3-benzodiazepine (GYKI 52466)

1994 • 57 citations

Interactions of 2,3‐benzodiazepines and cydothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices

1996 • 50 citations

Neuroprotective Effect of YM90K, a Novel AMPA/Kainate Receptor Antagonist, in Focal Cerebral Ischemia in Cats

1996 • 48 citations

6‐Cyano‐7‐nitroquinoxaline‐2,3‐dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus

1989 • 45 citations

Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists.

1995 • 37 citations

Evidence for direct interactions between the NMDA and glycine recognition sites in brain

1990 • 36 citations

Modulation of fast excitatory synaptic transmission by cyclothiazide and GYKI 52466 in the rat hippocampus

1994 • 32 citations