HIV‐1 Envelope Proteins gp120 and gp160 Potentiate NMDA‐induced [Ca²⁺]_i Increase, Alter [Ca²⁺]_i Homeostasis and Induce Neurotoxicity in Human Embryonic Neurons

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS

1984 • 1,429 citations

Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)

1985 • 718 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells.

1987 • 424 citations

Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity

1991 • 397 citations

Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms

1993 • 367 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.

1993 • 348 citations

Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains.

1991 • 289 citations

Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120.

1993 • 269 citations

Models of neuronal injury in AIDS: another role for the NMDA receptor?

1992 • 247 citations

Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoprotein.

1991 • 177 citations

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

1992 • 174 citations

Human immunodeficiency virus type 1–infected monocytic cells can destroy human neural cells after cell‐to‐cell adhesion

1992 • 166 citations

Human microglial cells: Characterization in cerebral tissue and in primary culture, and study of their susceptibility to HIV‐1 infection

1991 • 156 citations

Memantine prevents HIV coat protein‐induced neuronal injury in vitro

1992 • 153 citations

Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist

1992 • 148 citations

HIV envelope protein-induced neuronal damage and retardation of behavioral development in rat neonates

1993 • 132 citations

Transient increase of NMDA-binding sites in human hippocampus during development

1989 • 129 citations

Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures

1993 • 113 citations

Functional Interaction and Partial Homology Between Human Immunodeficiency Virus and Neuroleukin

1987 • 109 citations

HIV-related neuronal injury

1994 • 89 citations

HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons

1992 • 79 citations

Sensitivity of cultured human embryonic cerebral cortical neurons to excitatory amino acid-induced calcium influx and neurotoxicity

1991 • 74 citations

Glutamate recognition sites in human fetal brain

1988 • 69 citations

Calcium channel antagonists and human immunodeficiency virus coat protein–mediated neuronal injury

1991 • 66 citations

Effects of the HIV‐1 Envelope Glycoprotein gp120 in Cerebellar Cultures. [Ca²⁺]_i Increases in a Glial Cell Subpopulation

1993 • 32 citations

Long-term culture of neurones from human cerebral cortex in serum-free medium

1983 • 16 citations