Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1991 • 497 citations

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

1995 • 493 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

1995 • 471 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products

1984 • 394 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

Involvement of Free Radicals in Excitotoxicity In Vivo

1995 • 325 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

1990 • 312 citations

Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate

1993 • 303 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.

1992 • 292 citations

Striatal neurons containing both somatostatin‐ and avian pancreatic polypeptide (APP)‐like immunoreactivities and NADPH‐diaphorase activity: A light and electron microscopic study

1983 • 267 citations

Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

1993 • 226 citations

Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

1993 • 206 citations

On the pH-dependent yield of hydroxyl radical products from peroxynitrite

1994 • 202 citations

The enzymatic measurement of adenine nucleotides and P-creatine in picomole amounts

1981 • 164 citations

Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole

1994 • 131 citations

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

1992 • 129 citations

Malonate produces striatal lesions by indirect NMDA receptor activation

1994 • 88 citations

Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus

1992 • 84 citations

Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia

1991 • 82 citations

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-d-aspartate neurotoxicity

1993 • 73 citations

Potentiation of quinolinate-induced hippocampal lesions by inhibition of NO synthesis

1992 • 70 citations

The Inhibition of the Constitutive Bovine Endothelial Nitric Oxide Synthase by Imidazole and Indazole Agents

1994 • 65 citations

Potentiation of NMDA-mediated toxicity on nigrostriatal neurons by a low dose of 7-nitro indazole

1994 • 45 citations

NMDA neurotoxicity in murine cortical cell cultures is not attenuated by hemoglobin or inhibition of nitric oxide synthesis

1993 • 44 citations

Lack of involvement of nitric oxide in NMDA-induced neuronal cell death in cortical culture

1993 • 16 citations