Na+ channels as targets for neuroprotective drugs

A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

1994 • 2,067 citations

Effect of anoxia on ion distribution in the brain

1985 • 1,341 citations

Active propagation of somatic action potentials into neocortical pyramidal cell dendrites

1994 • 1,303 citations

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

1992 • 656 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

1994 • 630 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

1992 • 361 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

Coagulation factors and the increased risk of stroke in nonvalvular atrial fibrillation.

1990 • 310 citations

Na+ channels must deactivate to recover from inactivation

1994 • 303 citations

The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat

1992 • 290 citations

Common modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsants

1987 • 287 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

A novel, abundant sodium channel expressed in neurons and glia

1995 • 230 citations

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

1991 • 222 citations

Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

1991 • 219 citations

Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons.

1994 • 201 citations

Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

1994 • 185 citations

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

1993 • 180 citations

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine.

1982 • 173 citations

Zonisamide enhances slow sodium inactivation inMyxicola

1987 • 164 citations

Na+ currents that fail to inactivate

1993 • 160 citations

Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia

1992 • 153 citations

Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats

1995 • 148 citations

The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801

1992 • 140 citations

Neuroprotective Properties of the Novel Antiepileptic Lamotrigine in a Gerbil Model of Global Cerebral Ischemia

1995 • 132 citations

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability

1992 • 121 citations

The Sodium Channel Blocker and Glutamate Release Inhibitor BW1003C87 and Magnesium Attenuate Regional Cerebral Edema Following Experimental Brain Injury in the Rat

1995 • 120 citations

Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials

1994 • 119 citations

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

1993 • 118 citations

Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents

1994 • 116 citations

Pharmacological and electrographic properties of epileptiform activity induced by elevated K2+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices

1993 • 111 citations

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87

1992 • 107 citations

Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity

1994 • 106 citations

Flunarizine limits hypoxia-ischemia induced morphologic injury in immature rat brain.

1986 • 106 citations

Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.

1994 • 102 citations

Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient

1994 • 101 citations

Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium-channel blockade

1995 • 101 citations

Phenytoin protects against ischemia-produced neuronal cell death

1989 • 100 citations

Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischemia

1994 • 94 citations

Effect of riluzole on focal cerebral ischemia in rats

1993 • 89 citations

Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.

1991 • 88 citations

Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury

1995 • 72 citations

The barbiturate thiopental reduces ATP levels during anoxia but improves electrophysiological recovery and ionic homeostasis in the rat hippocampal slice

1992 • 66 citations

Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin

1988 • 65 citations

Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.

1994 • 63 citations

The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus

1991 • 63 citations

Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect

1994 • 60 citations

Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat

1993 • 56 citations

The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study

1993 • 55 citations

Endogenous bursts underlie seizurelike activity in solitary excitatory hippocampal neurons in microcultures

1994 • 55 citations

Lidocaine accelerates neuroelectrical recovery after incomplete global ischemia in rabbits.

1990 • 53 citations

Increased intracellular Na+ augments mobilization of Ca2+ from SR in vascular smooth muscle cells

1994 • 51 citations

Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.

1990 • 41 citations

Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia

1989 • 31 citations

Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats

1994 • 31 citations

Early changes in glucose metabolism in the cerebrum of senescence accelerated mouse: involvement of glucose transporter

1994 • 29 citations

Neuroprotective effects of carvedilol, a new antihypertensive, as a Na+ channel modulator and glutamate transport inhibitor

1994 • 23 citations

Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels.

1993 • 18 citations

Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-α-benzoate binding in vitro

1991 • 16 citations

Block of sodium channel current by anticonvulsant U-54494A in mouse neuroblastoma cells.

1992 • 14 citations

Inhibition of Na+ channels by the novel blocker PD85,639.

1993 • 9 citations

Deleted Work

1955 • 0 citations