The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.

1966 • 389 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

New class of glutamate agonist structurally related to ibotenic acid

1980 • 309 citations

Dissociative Anesthesia

1966 • 293 citations

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

1979 • 263 citations

The antagonism of amino acid-induced excitation of spinal neurones in the cat

1979 • 259 citations

Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.

1981 • 254 citations

Multiple opioid receptors

1981 • 221 citations

Neurobiology of Phencyclidine (Sernyl), A Drug With An Unusual Spectrum of Pharmacological Activity

1964 • 207 citations

Selective antagonism of amino acid‐induced and synaptic excitation in the cat spinal cord.

1979 • 195 citations

Glutamic acid : advances in biochemistry and physiology

1979 • 195 citations

Comparative pharmacology of the optical isomers of ketamine in mice

1978 • 192 citations

The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia

1972 • 163 citations

General Anesthetic and Other Pharmacological Properties of 2‐(O‐Chlorophenyl)‐2‐Methylamino Cyclohexanone HCl (CI‐581)

1965 • 150 citations

The synaptic excitation of Renshaw cells

1966 • 150 citations

PHYSICAL TECHNIQUES IN BIOLOGICAL RESEARCH

1963 • 143 citations

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

1982 • 127 citations

The involvement of opiate and monoaminergic neuronal systems in the analgesic effects of ketamine

1982 • 118 citations

On the pharmacology of the ketamine enantiomorphs in the rat.

1977 • 118 citations

ACTIONS OF <scp>l</scp>‐ AND <scp>d</scp>‐HOMOCYSTEATE IN RAT CNS: A CORRELATION BETWEEN LOW‐AFFINITY UPTAKE AND THE TIME COURSES OF EXCITATION BY MICROELECTROPHORETICALLY APPLIED L‐GLUTAMATE ANALOGUES

1977 • 117 citations

II. Multiple opioid receptors

1981 • 105 citations

Mg2+-like selective antagonism of excitatory amino acid-induced responses by α,ε-diaminopimelic acid, D-α-maminoadipate and HA-966 in isolated spinal cord of frog and immature rat

1978 • 93 citations

Properties of the optical isomers and metabolites of ketamine on the high affinity transport and catabolism of monoamines

1981 • 92 citations

Electrophysiological evidence for presynaptic actions of phencyclidine on noradrenergic transmission in rat cerebellum.

1980 • 89 citations

Lamina-specific Suppression of Dorsal-horn Unit Activity by Ketamine Hydrochloride

1973 • 87 citations

THE EFFECT OF ANAESTHETIC AGENTS ON CEREBRAL CORTICAL RESPONSES IN THE RAT

1982 • 82 citations

Selective antagonism by D-α-aminoadipate of amino acid and synaptic excitation of cat spinal neurons

1978 • 75 citations

D-α-Aminoadipate, α,ε-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synaptic excitation of mammalian spinal neurones in vivo

1978 • 71 citations

1‐Hydroxy‐3‐amino‐pyrrolidone‐2 (HA‐966): a new GABA‐like compound, with potential use in extrapyramidal diseases

1971 • 65 citations

AMINO ACIDS AS NEUROTRANSMITTERS OF CORTICOFUGAL NEURONES IN THE RAT: A COMPARISON OF GLUTAMATE AND ASPARTATE

1979 • 65 citations

THE EFFECT OF ANAESTHETICS ON THE UPTAKE AND RELEASE OF γ‐AMINOBUTYRATE AND D‐ASPARTATE IN RAT BRAIN SLICES

1981 • 60 citations

Sites of action of phencyclidine. III. Interactions with muscarinic receptors.

1980 • 58 citations

In vivo inactivation of quisqualate: studies in the cat spinal cord

1980 • 57 citations

Ketamine as the sole anaesthetic agent for minor surgical procedures

1971 • 54 citations

Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract.

1976 • 52 citations

Molecular Mechanisms in General Anesthesia

1975 • 51 citations

Use of ketamine hybrochloride as an anesthetic in laboratory rabbits, rats, mice, and guinea pigs.

1972 • 43 citations

Quantitative Aspects of Chemical Pharmacology

1979 • 43 citations

Effects of ketamine (CI 581) on cell responses to cutaneous stimulations in laminae IV and V in the cat's dorsal horn

1972 • 42 citations

Spinal-cord Depressant Effects of Ketamine and Etoxadrol* in the Cat and the Rat

1973 • 40 citations

Time course of GABA and glycine actions on cat spinal neurones: Effect of pentobarbitone

1978 • 35 citations

Effects of Ketamine on Nociceptive Cells in the Medial Medullary Reticular Formation of the Cat

1979 • 33 citations

Acetylcholine receptors on Renshaw cells of the rat

1975 • 30 citations

Topical reviews in anaesthesia

1980 • 27 citations

The effects of ketamine enantiomers on schedule-controlled behavior in the rat.

1980 • 26 citations

Action of phencyclidine on synaptic transmission in the hippocampus

1982 • 25 citations

Specific effects of α-<scp>D</scp>,<scp>L</scp>-aminoadipic acid on synaptic transmission in frog spinal cord

1980 • 25 citations

The use of ketamine (CI-581) in feline anaesthetic practice

1973 • 24 citations

Dissociation of limbic and neocortical EEG patterns in cats under ketamine anesthesia

1972 • 21 citations

Failure to Produce Analgesia with Ketamine in Two Patients with Cortical Disease

1972 • 15 citations

Neuronal responses to ketamine administered microiontophoretically or intraperitoneally in the rat

1979 • 15 citations

Neurophysiological approach as a tool to study effects of drugs on the central nervous system: Dose-effect of ketamine

1978 • 14 citations