Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

An Outbreak of Toxic Encephalopathy Caused by Eating Mussels Contaminated with Domoic Acid

1990 • 726 citations

Kainic acid: a powerful neurotoxic analogue of glutamate

1974 • 710 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

AMPA glutamate receptor subunits are differentially distributed in rat brain

1993 • 574 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels

1990 • 555 citations

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

1991 • 554 citations

Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate, and aspartate.

1980 • 545 citations

At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?

1991 • 535 citations

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1991 • 497 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin

1991 • 476 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

1991 • 454 citations

Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease

1990 • 431 citations

The role of epileptic activity in hippocampal and ‘remote’ cerebral lesions induced by kainic acid

1980 • 428 citations

Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Acidic amino acids with strong excitatory actions on mammalian neurones

1963 • 415 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells

1992 • 413 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine

1970 • 388 citations

Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.

1985 • 374 citations

LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA

1986 • 373 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

1993 • 359 citations

Calcium Entry Through Kainate Receptors and Resulting Potassium-Channel Blockade in Bergmann Glial Cells

1992 • 334 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Electrogenic glutamate uptake in glial cells is activated by intracellular potassium

1988 • 325 citations

Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology

1991 • 313 citations

New class of glutamate agonist structurally related to ibotenic acid

1980 • 309 citations

Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer

1991 • 303 citations

Abnormal glutamate metabolism in amyotrophic lateral sclerosis

1987 • 302 citations

On the use of ibotenic acid to lesion selectively different components of the hippocampal formation

1989 • 297 citations

L-Cysteine, a Bicarbonate-Sensitive Endogenous Excitotoxin

1990 • 259 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Glutamate-Induced Brain Damage in Infant Primates

1972 • 243 citations

Comparison of ibotenate and kainate neurotoxicity in rat brain: A histological study

1983 • 236 citations

Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus.

1993 • 226 citations

Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum

1990 • 218 citations

Neurotoxicity ofβ-N-methylamino-l-alanine (BMAA) andβ-N-oxalylamino-l-alamine (BOAA) on cultured cortical neurons

1989 • 206 citations

Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long‐Term Potentiation Through Protein Kinase C

1992 • 200 citations

Beta- N -Methylamino-L-Alanine Neurotoxicity: Requirement for Bicarbonate as a Cofactor

1988 • 199 citations

CSF amino acids and plasma‐CSF amino acid ratios in adults¹

1975 • 195 citations

Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.

1991 • 194 citations

2‐Amino‐3‐(methylamino)‐propanoic acid (BMAA) in cycad flour

1990 • 187 citations

The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model

1992 • 184 citations

Neurological disorders associated with deficiency of glutamate dehydrogenase

1984 • 183 citations

Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures

1991 • 175 citations

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

1992 • 167 citations

Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid

1990 • 163 citations

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

1991 • 161 citations

Neurotoxicity at the N‐Methyl‐D‐Aspartate Receptor in Energy‐Compromised Neurons An Hypothesis for Cell Death in Aging and Disease

1989 • 157 citations

Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition.

1991 • 157 citations

Specific antagonism of excitotoxic action of ‘uncommon’ amino acids assayed in organotypic mouse cortical cultures

1987 • 154 citations

The Treatment of Acetaminophen Poisoning

1983 • 153 citations

Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices

1986 • 153 citations

Pharmacologically distinct sodium-dependentl-[3H]glutamate transport processes in rat brain

1991 • 152 citations

Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat.

1992 • 145 citations

Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia

1991 • 143 citations

Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina

1991 • 142 citations

Excitotoxins: An Overview

1983 • 142 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

Amino Acid Composition of Proteins: Selection Against the Genetic Code

1975 • 137 citations

Evidence that the Loss of the Voltage‐Dependent Mg²⁺ Block at the N‐Methyl‐D‐Aspartate Receptor Underlies Receptor Activation During Inhibition of Neuronal Metabolism

1992 • 137 citations

Hippocampal damage produced by systemic injections of domoic acid in mice

1991 • 135 citations

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1992 • 135 citations

Potentiation of kainic acid epileptogenicity and sparing from neuronal damage by an NMDA receptor antagonist

1989 • 134 citations

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

1992 • 129 citations

Content of the neurotoxins cycasin (methylazoxymethanol β‐D‐glucoside) and BNLAA (β‐ N ‐methylamino‐L‐alanine) in cycad flour prepared by Guam Chamorros

1992 • 125 citations

The neurotoxicity of ouabain, a sodium-potassium ATPase inhibitor, in the rat hippocampus

1990 • 120 citations

Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

1991 • 117 citations

Two types of kainate response in cultured rat hippocampal neurons

1991 • 115 citations

Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain

1991 • 112 citations

Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid

1992 • 104 citations

Spider toxins affecting glutamate receptors: Polyamines in therapeutic neurochemistry

1991 • 103 citations

The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury

1992 • 102 citations

Ultrastructural analysis of kainic acid lesion to cerebellar cortex

1980 • 101 citations

Stereospecific acute neuronotoxicity of ‘uncommon’ plant amino acids linked to human motor-system diseases

1987 • 96 citations

Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures

1989 • 95 citations

β‐N‐Oxalylamino‐L‐Alanine Action on Glutamate Receptors

1989 • 94 citations

Facilitated Transport of the Neurotoxin, β‐N‐Methylamino‐<scp>l</scp>‐Alanine, Across the Blood‐Brain Barrier

1992 • 94 citations

Neurochemical characterization of excitotoxin lesions in the cerebral cortex

1991 • 94 citations

Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord

1989 • 94 citations

Effect of Aspartame and Aspartate Loading upon Plasma and Erythrocyte Free Amino Acid Levels in Normal Adult Volunteers

1977 • 93 citations

Safety of Long-term Large Doses of Aspartame

1989 • 90 citations

Quinolinate differentiates between forebrain and cerebellar NMDA receptors

1991 • 81 citations

Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices

1986 • 79 citations

Do seizures cause brain damage?

1991 • 78 citations

β-N-Methylamino-l-alanine

1989 • 78 citations

Morphological changes in rat brain induced byl-cysteine injection in newborn animals

1981 • 78 citations

Brain and retinal damage from lathyrus excitotoxin, β-N-oxalyl-L-α,β-diaminopropionic acid

1976 • 77 citations

Selective degeneration of cerebellar cortical neurons caused by cycad neurotoxin, L‐β‐methylaminoalanine (L‐BMAA), in rats

1990 • 75 citations

Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

1992 • 74 citations

Cysteine-induced brain damage in infant and fetal rodents

1972 • 74 citations

Neuroactive carbamate adducts of beta-N-methylamino-L-alanine and ethylenediamine. Detection and quantitation under physiological conditions by 13C NMR.

1990 • 74 citations

Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist

1989 • 70 citations

Regional Heterogeneity of L‐Glutamate and L‐Aspartate High‐Affinity Uptake Systems in the Rat CNS

1991 • 69 citations

The response of the hypothalamus to high doses of monosodium glutamate in mice and monkeys

1971 • 68 citations

Human milk nonprotein nitrogen components: changing patterns of free amino acids and urea in the course of early lactation

1984 • 68 citations

D,L-(Tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist

1991 • 67 citations

Identification of a Novel N‐Methyl‐D‐Aspartate Receptor Population in the Rat Medial Thalamus

1992 • 67 citations

Neurological disease and mitochondrial genes

1991 • 67 citations

Monosodium Glutamate: Absence of Hypothalamic Lesions after Ingestion by Newborn Primates

1971 • 67 citations

Immunological detection of glutamate receptor subtypes in human central nervous system

1992 • 66 citations

Central Effects of β-N-Oxalyl-α,β-diaminopropionic Acid and other Lathyrus Factors

1966 • 66 citations

Neurotoxic effects of excitatory amino acids in the mouse spinal cord: quisqualate and kainate but not N-methyl-l-aspartate induce permanent neural damage

1990 • 65 citations

Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system

1992 • 64 citations

Differential dependence on Ca2+ of and quisqualate neurotoxicity in young rat hippocampal slices

1989 • 63 citations

GYKI 52466, an inhibitor of spinal reflexes is a potent quisqualate antagonist

1990 • 62 citations

Autoradiographic characterization of putative excitatory amino acid transport sites

1990 • 62 citations

Acromelic acid is a much more potent excitant than kainic acid or domoic acid in the isolated rat spinal cord

1988 • 61 citations

Acromelic acid, a novel excitatory amino acid from a poisonous mushroom: effects on the crayfish neuromuscular junction

1986 • 57 citations

The cortical lesion of Huntington's disease: Further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N‐methyl‐<scp>D</scp>‐aspartate lesions of rat cortex

1992 • 54 citations

Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: A preliminary report

1976 • 54 citations

cis-2,4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist

1990 • 52 citations

Quisqualate‐ and NMDA‐sensitive [³H]glutamate binding in primate brain

1990 • 52 citations

Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: Effects of MK-801 and kynurenate

1989 • 50 citations

A microiontophoretic study of the action of kainic acid and putative neurotransmitters in the rat mesencephalic trigeminal nucleus

1980 • 50 citations

Blockade of N-methyl-d-aspartate receptors prevents cyanide-induced neuronal injury in primary hippocampal cultures

1992 • 50 citations

Receptor site specificity for the acute effects of β-N-methylamino-alanine in mice

1990 • 50 citations

Comparative toxicities of α- and β-N-oxalyl-l-α,β-diaminopropionic acids to rat spinal cord

1985 • 49 citations

The administration of monosodium l-glutamate to neonatal and pregnant rhesus monkeys

1973 • 48 citations

Stimulation of pituitary hormone secretion by neurotransmitter amino acids in humans

1989 • 46 citations

Effects of dietary supplementation of monosodium glutamate on infant monkeys, weanling rats, and suckling mice

1973 • 45 citations

Chemical synthesis of Nβ-oxalyl-L-α,β-diaminopropionic acid and optical specificity in its neurotoxic action

1975 • 43 citations

Toxicity of protein hydrolysate solutions: Correlation of glutamate dose and neuronal necrosis to plasma amino acid levels in young mice

1974 • 43 citations

NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema

1992 • 42 citations

A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture

1991 • 42 citations

Differential sensitivity of rat cerebellar cells in vitro to the neurotoxic effects of excitatory amino acid analogues

1984 • 41 citations

Enhancement of NMDA receptor-mediated neurotoxicity in the hippocampal slice by depolarization and ischemia

1991 • 41 citations

Lathyrus excitotoxin: mechanism of neuronal excitation by L-2-oxalylamino-3-amino- and L-3-oxalylamino-2-amino-propionic acid

1984 • 41 citations

α‐[³H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid Binding to Human Cerebral Cortical Membranes: Minimal Changes in Postmortem Brains of Chronic Schizophrenics

1992 • 38 citations

Excitotoxic mechanisms, and age-related susceptibility to brain damage in ischemia, hypoglycemia and toxic mussel poisoning.

1991 • 35 citations

Gliotoxic properties of theLathyrus excitotoxinβ-N-oxalyl-l-α,β-diaminopropionic acid (β-l-ODAP)

1991 • 34 citations

Specific lesions of rat spinal interneurons induced by systemic administration of acromelic acid, a new potent kainate analogue

1989 • 34 citations

Spinal neuronal pathology associated with continuous intrathecal infusion ofN-methyl-d-aspartate in the rat

1990 • 34 citations

Free amino acids in preterm and term milk from mothers delivering appropriate- or small-for-gestational-age infants

1989 • 32 citations

Plasma and Erythrocyte Amino Acid Levels in Normal Adult Subjects Fed a High Protein Meal with and without Added Monosodium Glutamate

1982 • 30 citations

Actions of agonists of metabotropic glutamate receptors on synaptic transmission and transmitter release in the olfactory cortex

1993 • 29 citations

Electron microscopic observations of hypothalami in neonatal rhesus monkeys (Macaca mulatta) after administration of monosodium-L-glutamate

1975 • 29 citations

Synaptosomal Glutamate Uptake Declines Progressively in the Spinal Cord of a Mutant Mouse with Motor Neuron Disease

1993 • 29 citations

Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog

1991 • 28 citations

Effect of aspartame plus monosodium ʟ-glutamate ingestion on plasma and erythrocyte amino acid levels in normal adult subjects fed a high protein meal

1982 • 27 citations

Correlation of glutamate plus aspartate dose, plasma amino acid concentration and neuronal necrosis in infant mice

1985 • 26 citations

The mechanism of glutamate-induced degeneration of cultured Huntington's disease and control fibroblasts

1985 • 25 citations

Acromelic acid, a novel kainate analogue, induces long-lasting paraparesis with selective degeneration of interneurons in the rat spinal cord

1992 • 25 citations

Methionine, Cysteine, Cystine, and Taurine Interrelationships in Human Plasma

1969 • 24 citations

Plasma amino acid concentrations in normal adults ingesting aspartame and monosodium l-glutamate as part of a soup/beverage meal

1987 • 23 citations

Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: possible role of glycine.

1991 • 22 citations

Effect of Starch Ingestion on Plasma Glutamate Concentrations in Humans Ingesting Monosodium L-Glutamate in Soup

1985 • 18 citations

Correlation of aspartate dose, plasma dicarboxylic amino acid concentration, and neuronal necrosis in infant mice

1983 • 17 citations

Experimental neurolathyrism in monkeys.

1971 • 17 citations

Anatomical and pharmacological heterogeneity of D-[3H]aspartate binding sites

1990 • 16 citations

Plasma Glutamate Concentrations in 1-Year-Old Infants and Adults Ingesting Monosodium L-Glutamate in Consommé

1986 • 14 citations

Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate

1986 • 13 citations

TOXIC FACTORS IN LATHYRUS SATIVUS.

1965 • 11 citations

Glutamate enhances brain damage and albumin content in cerebrospinal fluid after intracarotid protamine infusion

1993 • 11 citations

Systematic glutamate induces degeneration of a subpopulation of tyrosine hydroxylase-immunoreactive neurons in the rat area postrema

1990 • 10 citations

7. The non-excitatory mechanisms of glutamate induced neurotoxicity

1991 • 9 citations

l-Glutamate transporter derived from mRNAs of primary glial cultures: expression in Xenopus laevis oocytes

1992 • 6 citations

Lathyrism Can it be a model for motor neurone disease

1992 • 1 citations