Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease

1985 • 614 citations

Transcriptional Activation Modulated by Homopolymeric Glutamine and Proline Stretches

1994 • 598 citations

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1990 • 477 citations

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

1993 • 411 citations

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

1993 • 338 citations

Huntington's disease : a disorder of families

1989 • 324 citations

Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis.

1991 • 293 citations

Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals

1995 • 223 citations

Characterization and localization of the Huntington disease gene product

1993 • 202 citations

Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis

1995 • 159 citations

Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles

1993 • 134 citations

Intracellular protein trafficking defects in human disease

1992 • 96 citations

Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal

1993 • 95 citations

Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail

1992 • 69 citations

The synaptic vesicle and its targets

1995 • 66 citations

The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking

1992 • 50 citations

Molecular Approaches to Hereditary Diseases of the Nervous System: Huntington's Disease as a Paradigm

1991 • 40 citations

[49] The isolation of lysosomes from brain

1974 • 30 citations

A chloride- and calcium-dependent glutamate-binding protein from rat brain. Identification as a ubiquitous constituent of the inner mitochondrial membrane.

1990 • 18 citations

Methods in Enzymology. Biomembranes, Part 'A'

1974 • 14 citations

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