Apoptosis in the Nervous System: Morphological Features, Methods, Pathology, and Prevention.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Identification and characterization of a spinal muscular atrophy-determining gene

1995 • 3,722 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Excitotoxic cell death

1992 • 2,307 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1951 • 947 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

1995 • 694 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons

1995 • 593 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Neurotrophins and brain insults

1994 • 564 citations

A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

1992 • 523 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

1994 • 488 citations

Neurotrophin-6 is a new member of the nerve growth factor family

1994 • 404 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Apoptosis and necrosis. Basic types and mechanisms of cell death.

1993 • 353 citations

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1978 • 318 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

Ultrastructural differences during embryonic cell death in normal and peripherally deprived ciliary ganglia.

1976 • 266 citations

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

1994 • 251 citations

Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry

1994 • 245 citations

Dependence of postnatal motoneurones on their targets: review and hypothesis

1992 • 245 citations

Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse

1994 • 242 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Neurotrophins and Their Receptors—Current Concepts and Implications for Neurologic Disease

1993 • 232 citations

Motoneuron death after sciatic nerve section in newborn rats

1984 • 213 citations

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

1993 • 205 citations

Cell death of motoneurons in the chick embryo spinal cord

1984 • 203 citations

Axotomy‐induced neuronal death during development

1992 • 198 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Oxygen radicals as key mediators in neurological disease: Fact or fiction?

1992 • 186 citations

Cellular death and necrosis: Chemical, physical and morphologic changes in rat liver

1960 • 182 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

The apoptosis endonucleases: cleaning up after cell death?

1994 • 160 citations

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.

1989 • 144 citations

The cell cycle and cell death

1993 • 137 citations

Somatic and autonomic nerve-muscle interactions

1983 • 133 citations

Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons

1988 • 127 citations

Programmed cell death during the earliest stages of spinal cord development in the chick embryo: A possible means of early phenotypic selection

1994 • 126 citations

Evidence for autoimmunity in amyotrophic lateral sclerosis

1993 • 121 citations

Über Untergang von Zellen während der normalen Entwicklung bei Wirbeltieren

1926 • 121 citations

Phenotype‐specific “tissue” transglutaminase regulation in human neuroblastoma cells in response to retinoic acid: Correlation with cell death by apoptosis

1992 • 119 citations

Apoptosis associated DNA fragmentation in epileptic brain damage

1994 • 114 citations

Biological studies of a putative avian muscle‐derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo

1993 • 112 citations

Cell death in normal development.

1965 • 111 citations

Programmed cell death—IV. The influence of drugs on the breakdown of the intersegmental muscles of silkmoths

1965 • 107 citations

The dependence of motoneurons on their target muscle during postnatal development of the mouse

1990 • 104 citations

A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.

1995 • 96 citations

Apoptosis And Programmed Cell Death In Immunity

1992 • 89 citations

Apoptosis and Free Radicals

1994 • 87 citations

Trophic Support of Motoneurons: Physiological, Pathophysiological, and Therapeutic Implications

1993 • 84 citations

Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death

1994 • 68 citations

Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse

1994 • 64 citations

Apoptotic Cell Death of a Hybrid Motoneuron Cell Line Induced by Immunoglobulins from Patients with Amyotrophic Lateral Sclerosis

1994 • 61 citations

Neuronal death, cytoplasmic calcium and internucleosomal DNA fragmentation: evidence for DNA fragments being released from cells

1993 • 61 citations

Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro

1994 • 56 citations

Evidence for autoimmunity in amyotrophic lateral sclerosis

1994 • 51 citations

Possible role of neuronal apoptosis in Alzheimer's disease

1994 • 35 citations

Neurotrophic Factors in the Treatment of Motor Neuron Disease and Trauma

1993 • 13 citations

Chapter 25 Neuronal responses to injury and aging: lessons from animal models

1990 • 7 citations

The BCL-2 Gene: A Regulator of Programmed Cell Death

1994 • 3 citations

Motoneuron death during development, following injury and in neurological disease

1994 • 3 citations

Glia: The brain's other cells

1995 • 2 citations

Deleted Work

1955 • 0 citations