Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Selective Sparing of a Class of Striatal Neurons in Huntington's Disease

1985 • 767 citations

II. Excitotoxic models for neurodegenerative disorders

1984 • 469 citations

Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum

1981 • 332 citations

NEUROCHEMICAL ALTERATIONS IN HUNTINGTON'S CHOREA

1980 • 285 citations

PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline

1986 • 268 citations

Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease

1987 • 253 citations

Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease

1985 • 251 citations

Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to <scp>l</scp>‐Kynurenine

1989 • 221 citations

Neural grafting in a rat model of huntington's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting

1985 • 201 citations

Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat

1988 • 201 citations

Degeneration of pyramidal projection neurons in Huntington's disease cortex

1990 • 193 citations

Reversal of long-term locomotor abnormalities in the kainic acid model of huntington's disease by day 18 fetal striatal implants

1983 • 185 citations

Neuropeptides in neurological disease

1986 • 162 citations

Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists

1988 • 130 citations

No evidence for preservation of somatostatin-containing neurons after intrastriatal injections of quinolinic acid

1987 • 126 citations

Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection

1990 • 126 citations

Short- and long-term consequences of intracranial injections of the excitotoxin, quinolinic acid, as evidenced by GFA immunohistochemistry of astrocytes

1986 • 122 citations

AMINO ACID NEUROTRANSMITTER ABNORMALITIES IN HUNTINGTON'S DISEASE AND THE QUINOLINIC ACID ANIMAL MODEL OF HUNTINGTON'S DISEASE

1987 • 115 citations

Brain Quinolinic Acid in Huntington's Disease

1988 • 111 citations

Topography of enkephalin, substance P and acetylcholinesterase staining in Huntington's disease striatum

1986 • 109 citations

Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

1988 • 105 citations

Quinolinic acid does not spare striatal neuropeptide Y-immunoreactive neurons

1987 • 98 citations

EC array sensor concepts and data

1987 • 93 citations

Somatostatin and neuropeptide Y concentrations in pathologically graded cases of huntington's disease

1988 • 88 citations

Synaptic localization of striatal NMDA, quisqualate and kainate receptors

1989 • 87 citations

Long-term sequelae of striatal kainate lesion

1978 • 85 citations

Serotonin-1 receptor binding sites in the human basal ganglia are decreased in huntington's chorea but not in parkinson's disease: A quantitative in vitro autoradiography study

1989 • 85 citations

Neuropeptide Y in the cerebral cortex and the caudate-putamen nuclei: ultrastructural basis for interactions with GABAergic and non-GABAergic neurons

1989 • 83 citations

Neurotransmitter receptor alterations in Huntington's disease: Autoradiographic and homogenate studies with special reference to benzodiazepine receptor complexes

1985 • 82 citations

Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection

1987 • 79 citations

Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brain

1987 • 75 citations

Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

1991 • 69 citations

Tyrosine hydroxylase-like immunoreactivity is distributed in the matrix compartment of normal human and Huntington's disease striatum

1987 • 66 citations

Loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with Huntington's Disease¹

1977 • 63 citations

A detailed examination of substance P in pathologically graded cases of Huntington's disease

1988 • 54 citations

An examination of neuropeptide Y postmortem stability in an animal model simulating human autopsy conditions

1986 • 54 citations

Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the glutamate receptor domain

1989 • 52 citations

Effects of Chronic Striatal Kainate Lesions on Some Dopaminergic Parameters and Enkephalin Immunoreactive Neurons in the Basal Ganglia

1980 • 43 citations

Short‐ and long‐term survival of large neurons in the excitotoxic lesioned rat caudate nucleus: A light and electron microscopic study

1989 • 42 citations

Kainic acid lesions of the striatum in rats mimic the spontaneous motor abnormalities of Huntington's disease

1979 • 42 citations

‘Choreic’ movement induced by unilateral kainate lesion of the striatum and l-DOPA administration in monkey

1986 • 36 citations

Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease

1985 • 35 citations

Regulation of neurotensin-containing neurons in the rat striatum. Effects of unilateral striatal lesions with quinolinic acid and ibotenic acid on neurotensin content and its binding site density

1990 • 28 citations

Effects of intracerebral injections of quinolinic acid on serotonergic neurons in the rat brain

1985 • 16 citations

GABA and benzodiazepine receptors in basal ganglia function

1984 • 6 citations

122 NEUROPATHOLOGIC CLASSIFICATION OF HUNTINGTONʼS DISEASE

1983 • 6 citations