Phencyclidine

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Stereotyped activities produced by amphetamine in several animal species and man

1967 • 612 citations

Quantitative studies on some antagonists of N‐methyl D‐aspartate in slices of rat cerebral cortex

1985 • 487 citations

Phencyclidine-induced psychosis

1978 • 482 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

The action of N‐methyl‐D‐aspartic acid on mouse spinal neurones in culture.

1985 • 417 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

1984 • 348 citations

STIMULATORY EFFECT OF <scp>l</scp>‐GLUTAMATE AND RELATED AMINO ACIDS ON [³H]DOPAMINE RELEASE FROM RAT STRIATUM: AN IN VITRO MODEL FOR GLUTAMATE ACTIONS

1979 • 315 citations

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

1979 • 263 citations

Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

1985 • 261 citations

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

1982 • 258 citations

Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.

1981 • 254 citations

Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotypes behavior and ataxia in rats

1979 • 236 citations

The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.

1959 • 233 citations

Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain

1977 • 214 citations

Naloxone-inaccessible sigma receptor in rat central nervous system.

1983 • 214 citations

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

1984 • 199 citations

A STUDY OF A 1-ARYL CYCLO HEXYL AMINE FOR ANESTHESIA*

1958 • 194 citations

Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.

1986 • 187 citations

Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists

1986 • 182 citations

Interaction of phencyclidines with the muscarinic and opiate receptors in the central nervous system

1978 • 179 citations

(+)-[3H]SKF 10,047, (+)-[3H]ethylketocyclazocine, μ, κ, δ and phencyclidine binding sites in guinea pig brain membranes

1985 • 168 citations

Stereoisomers of N -Allylnormetazocine: Phencyclidine-Like Behavioral Effects in Squirrel Monkeys and Rats

1982 • 165 citations

Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat

1982 • 162 citations

The effects of phencyclidine on the uptake of 3H-catecholamines by rat striatal and hypothalamic synaptosomes

1976 • 161 citations

Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices

1982 • 157 citations

Phencyclidine-like discriminative effects of opioids in the rat.

1980 • 155 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

Demonstration of [3H]cyclazocine binding to multiple opiate receptor sites.

1981 • 151 citations

Neural and Endocrine Peptides and Receptors

1986 • 144 citations

Psychotomimetics as anticholinergic agents—I

1974 • 142 citations

Identification and Characterization of an N‐Methyl‐D‐Aspartate‐Specific L‐[³H]Glutamate Recognition Site in Synaptic Plasma Membranes

1987 • 131 citations

Phencyclidine selectively blocks a spinal action of N-methyl-d-aspartate in mice

1986 • 130 citations

Perspectives

1976 • 129 citations

High correlation between the localization of [3H]TCP binding and NMDA receptors

1986 • 128 citations

Potential antipsychotic BMY 14802 selectively binds to sigma sites

1987 • 128 citations

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

1982 • 127 citations

Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics

1979 • 125 citations

Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra

1984 • 124 citations

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 • 124 citations

Evaluation of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat.

1981 • 122 citations

Endogenous ligands for sigma opioid receptors in the brain (“sigmaphin”): Evidence from binding assays

1986 • 117 citations

Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata.

1981 • 113 citations

Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.

1985 • 109 citations

Evidence for an endogenous peptide ligand for the phencyclidine receptor

1984 • 102 citations

An endogenous ligand for the sigma opioid binding site

1987 • 102 citations

Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain

1987 • 92 citations

Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane

1980 • 89 citations

Biochemical properties of the brain phencyclidine receptor

1982 • 86 citations

Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices.

1982 • 85 citations

Comparison of s‐ and κ‐ opiate receptor ligands as excitatory amino acid antagonists

1984 • 83 citations

Psychotropic drug influences on brain acetylcholine utilization

1972 • 83 citations

A specific acylating agent for the [³H]phencyclidine receptors in rat brain

1985 • 80 citations

[3H]Phencyclidine: a probe for the ionic channel of the nicotinic receptor.

1980 • 80 citations

Discriminative stimulus effects of cyclazocine in the rat.

1980 • 79 citations

Stereotyped behavior correlates better than ataxia with phencyclidine-receptor interactions

1986 • 79 citations

Selective memory impairment by phencyclidine in rats

1987 • 77 citations

Sites of action of phencyclidine. II. Interaction with the ionic channel of the nicotinic receptor.

1980 • 76 citations

Anticonvulsant properties of phencyclidine-like drugs in mice

1985 • 76 citations

Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes.

1984 • 76 citations

Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.

1984 • 71 citations

Pharmacological evaluation of N-allynormetazocine (SKF 10,047) on the basis of its discriminative stimulus properties in the rat.

1983 • 70 citations

Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: Comparisons to other psychomotor stimulants

1983 • 68 citations

The behavioral effects of phencyclidines may be due to their blockade of potassium channels.

1981 • 67 citations

The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain

1987 • 63 citations

Psychotomimetic drugs as anticholinergic agents. II. Quantum-mechanical study of molecular interaction potentials of 1-cyclohexylpiperidine derivatives with the cholinergic receptor.

1973 • 61 citations

Phencyclidine-like discriminative stimuli of (+)- and (−)-N-allylnormetazocine in rats

1982 • 60 citations

Sites of action of phencyclidine. III. Interactions with muscarinic receptors.

1980 • 58 citations

Psychotomimetic opiate receptors labelled and visualized with (+)[^3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine

1984 • 57 citations

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

1986 • 54 citations

Anticholinesterase and antiacetylcholine activity of 1-phenylcyclohexylamine derivatives

1977 • 54 citations

Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.

1986 • 53 citations

Autoradiographic distribution of phencyclidine receptors in the rat brain using [3H]1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP)

1986 • 50 citations

A comparison between classes of drugs having phencyclidine-like behavioral properties on dopamine efflux in vitro and dopamine metabolism in vivo.

1984 • 50 citations

Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro

1985 • 49 citations

The action of certain cyclothexamines on hippocampal system during approach performance in the cat.

1960 • 46 citations

Cocaine, phencyclidine, and procaine inhibition of the acetylcholine receptor: characterization of the binding site by stopped-flow measurements of receptor-controlled ion flux in membrane vesicles

1986 • 46 citations

[3H]Phencyclidine interactions with the nicotinic acetylcholine receptor channel and its inhibition by psychotropic, antipsychotic, opiate, antidepressant, antibiotic, antiviral, and antiarrhythmic drugs.

1982 • 45 citations

Reaction of quinacrine mustard with the acetylcholine receptor from Torpedo californica.

1983 • 45 citations

Stereospecific displacement of the [3H]phencyclidine (PCP) receptor binding by an enentiomeric pair of PCP analogs

1981 • 44 citations

A comparison of PCP-like compounds for NMDA antagonism in two models

1988 • 43 citations

Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat

1982 • 43 citations

The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats

1987 • 40 citations

The convulsant and anticonvulsant effects of phencyclidine (PCP) and PCP analogues in the rat

1986 • 40 citations

Effects of psychoactive agents on acquisition of conditioned pole jumping in rats

1965 • 39 citations

Phencyclidine-Induced Immunodepression

1984 • 39 citations

Phencyclidine-induced release of [3H]dopamine from chopped striatal tissue

1982 • 39 citations

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

1986 • 38 citations

Interactions between Δ9-Tetrahydrocannabinol and phencyclidine hydrochloride in rats

1977 • 38 citations

The effect of some hallucinogenic drugs on the amino acid precursors of brain monoamines

1970 • 36 citations

Certain calcium antagonists are potent displacers of [3H]phencyclidine (PCP) binding in rat brain

1982 • 35 citations

Chronic Phencyclidine (PCP) Abuse: A Psychiatric Perspective

1980 • 34 citations

Metaphit, an acylating ligand for phencyclidine receptors: characterization of in vivo actions in the rat.

1986 • 34 citations

An endogenous ligand of the brain σ/PCP receptor antagonizes NMDA-induced neurotransmitter release

1987 • 34 citations

Combined sernyl and sensory deprivation

1960 • 33 citations

Some effects of an hallucinogenic drug (phencyclidine) on neurohumoral substances

1970 • 33 citations

Phencyclidine ("angel dust") analogs and sigma opiate benzomorphans cause cerebral arterial spasm.

1983 • 32 citations

Electrophysiological effects of phencyclidine on rat hippocampal pyramidal neurons

1981 • 31 citations

Structure-function relationships in the inhibition of synaptosomal dopamine uptake by phencyclidine and analogues: potential correlation with binding site identified with [3H]phencyclidine

1984 • 30 citations

The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord

1984 • 28 citations

Depressive states and their borderlands: Classification, diagnosis and treatment

1960 • 28 citations

Persistence of phencyclidine (PCP) and metabolites in brain and adipose tissue and implications for long-lasting behavioural effects.

1979 • 28 citations

Effects of Intravenous Anesthetics on Brain Monoamines in the Rat

1973 • 27 citations

Localization of phencyclidine binding sites on alpha and beta subunits of the nicotinic acetylcholine receptor from Torpedo ocellata electric organ using azido phencyclidine

1984 • 25 citations

Mechanism of phencyclidine binding to the acetylcholine receptor from Torpedo electroplaque.

1984 • 25 citations

Candidate mechanisms underlying phencyclidine-induced psychosis: an electrophysiological behavioral, and biochemical study.

1982 • 24 citations

Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis

1967 • 24 citations

Subjective effects of narcotic antagonists.

1973 • 24 citations

Phencyclidine and the dynamics of mouse brain histamine.

1985 • 23 citations

Phencyclidine and behavior: I. Sensory-motor function, activity level, taste aversion and water intake

1981 • 23 citations

Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity

1984 • 22 citations

Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

1982 • 21 citations

Stimulation of synaptosomal tyrosine hydroxylation by phencyclidine in vitro

1981 • 21 citations

m-Azido-phencyclidine covalently labels the rat brain PCP receptor, a putative K channel

1986 • 20 citations

Benz(F)isoquinolines as excitatory amino acid antagonists: An indication of their mechanism of action?

1984 • 20 citations

Calcium-dependent GABA release from mouse brain slices following acute and chronic phencyclidine administration

1981 • 20 citations

Enhancement of brain calcium antagonist binding by phencyclidine and related compounds

1986 • 20 citations

EFFECTS OF PHENCYCLIDINE AND ITS DERIVATIVES ON ENTERIC NEURONES

1982 • 19 citations

Actions of phencyclidine on the action potential and membrane currents of single guinea-pig myocytes.

1986 • 19 citations

[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity

1987 • 19 citations

Interaction of phencyclidine with drugs affecting noradrenaline metabolism in the rat brain

1972 • 19 citations

High affinity binding of phencyclidine (PCP) to crayfish muscle. displacement by calcium antagonists

1982 • 18 citations

Isomers of cyclazocine as excitatory amino acid antagonists

1984 • 17 citations

Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain

1985 • 16 citations

Site of action of phencyclidine. IV. Interaction of phencyclidine and its analogues on ionic channels of the electrically excitable membrane and nicotinic receptor: implications for behavioral effects.

1982 • 16 citations

Phencyclidine and Analogues: Effects on Brain Protein Synthesis

1984 • 15 citations

Stereoselective effects of two phencyclidine derivatives on N-methylaspartate excitation of spinal neurones in the cat and rat

1983 • 15 citations

Interactions of metaphit with phencyclidine and sigma agonist actions in rat cerebellum: determination of specificity and selectivity.

1987 • 15 citations

Effects of phencyclidine on the release of radioactivity from rat striatal slices labeled with [3H]choline.

1983 • 15 citations

Effects of Psychotropic Compounds on Enzyme Systems, II. In vitro Inhibition of Monoamine Oxidase.

1961 • 15 citations

Selective blockade of an excitatory synapse in rat cerebral cortex by the sigma opiate cyclazocine: An intracellular, in vitro study

1985 • 15 citations

Phenylcyclohexylamine: Effect of a metabolite of phencyclidine on the efflux of dopamine in the rat

1986 • 14 citations

Displacement of [3H]phencyclidine binding to Torpedo electric organ membrane by calcium channel antagonists

1984 • 12 citations

The effects in vitro of 1-(1-phenylcyclohexyl) piperidine hydrochloride (sernyl) on oxidation by liver homogenates and mitochondria of rat

1962 • 12 citations

Interactions of phencyclidine with crayfish muscle membranes. Sensitivity to calcium channel antagonists and other drugs.

1984 • 11 citations

(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine [(+)-3-PPP] but not (-)-3-PPP produces (+)-N-Allynormetazocine-like (SKF 10,047) discriminative stimuli

1986 • 11 citations

Isolation and identification of an endogenous ligand for the phencyclidine receptor.

1986 • 11 citations

Differential effects of phencyclidine upon hippocampal complex-spike and theta neurons

1984 • 11 citations

Acylating phencyclidines irreversibly enhance brain calcium antagonist binding

1986 • 10 citations

Cardiovascular and plasma prolactin responses to stereoisomers of phencyclidine

1983 • 10 citations

Actions of phencyclidine on the perfused rabbit ear

1968 • 9 citations

2-methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA)

1986 • 9 citations

Do kappa opioids mimic sigma agonists as amino acid antagonists?

1986 • 9 citations

Isolation of a factor (substance B) that antagonizes presynaptic modulation: pharmacological properties.

1986 • 8 citations

The effects of 1-(1-phenylcyclohexyI)piperidine·HC1 (phencyclidine, Sernyl) on respiration and related reactions of liver mitochondria in vitro

1968 • 8 citations

Management of PCP intoxication.

1985 • 6 citations

The effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro

1983 • 5 citations

Effect of Phencyclidine on the Metabolism of Individual Brain Proteins

1986 • 4 citations

Determination of the Pharmacokinetics of 2-Amino-7-Phosphonoheptanoate in Plasma and Cerebrospinal Fluid

1988 • 4 citations

Central phencyclidine (PCP) receptor binding is glutamate dependent: evidence for a PCP/excitatory amino acid receptor (EAAR) complex

1986 • 3 citations

Distinct endogenous ligands for PCP and sigma opioid receptors

1988 • 3 citations

Historical and Current Perspective

2018 • 2 citations