Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

1977 • 375 citations

A role for GABAB receptors in excitation and inhibition of thalamocortical cells

1991 • 354 citations

Gabapentin

1993 • 321 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

Lamotrigine

1993 • 300 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

1993 • 272 citations

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

1993 • 254 citations

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies

1993 • 227 citations

ucb L059, a novel anti-convulsant drug: pharmacological profile in animais

1992 • 208 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_<scp>A</scp> receptors

1994 • 200 citations

Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain

1991 • 191 citations

Mechanism of action of the anticonvulsant felbamate: Opposing effects on N‐methyl‐<scp>D</scp>‐aspartate and γ‐aminobutyric acid_A receptors

1994 • 175 citations

GABAergic mechanisms in the pathogenesis and treatment of epilepsy.

1989 • 170 citations

The NMDA Receptor, NMDA Antagonists and Epilepsy Therapy

1992 • 165 citations

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies

1993 • 159 citations

Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors.

1993 • 156 citations

Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin

1993 • 145 citations

A Neuropharmacological Evaluation of Felbamate as a Novel Anticonvulsant

1992 • 145 citations

Calcium‐Dependent Regulation of Genetically Determined Spike and Waves by the Reticular Thalamic Nucleus of Rats

1993 • 143 citations

Excitatory amino acids in epilepsy and potential novel therapies

1992 • 131 citations

Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate

1993 • 121 citations

Felbamate

1993 • 116 citations

Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons

1988 • 112 citations

Antiepileptic Drug Mechanisms of Action

1993 • 110 citations

The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients.

1989 • 93 citations

Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes

1986 • 93 citations

Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture

1994 • 86 citations

Basic aspects of epilepsy.

1993 • 77 citations

Cellular Mechanisms of Epilepsy and Potential New Treatment Strategies

1989 • 74 citations

[3H]Gabapentin may label a system-L-like neutral amino acid carrier in brain

1993 • 65 citations

New Antiepileptic Drugs: From Serendipity to Rational Discovery

1992 • 62 citations

Place of Newer Antiepileptic Drugs in the Treatment of Epilepsy

1993 • 60 citations

Effects of Vigabatrin (γ‐vinyl GAB A) on Neuro transmission‐Related Amino Acids and on GAB A nd Benzodiazepine Receptor Binding in Rats

1991 • 60 citations

Pharmacology of Vigabatrin

1992 • 51 citations

Stereoselective uptake of the GABA-transaminase inhibitors gamma-vinyl gaba and gamma-acetylenic GABA into neurons and astrocytes

1986 • 50 citations

Response to vigabatrin in relation to seizure type.

1989 • 50 citations

Emerging antiepileptic drugs.

1993 • 46 citations

New Antiepileptic Drugs

1992 • 42 citations

Effect of vigabatrin on striatal dopamine receptors: evidence in humans for interactions of GABA and dopamine systems.

1992 • 34 citations

Selective antagonism of the anticonvulsant effects of felbamate by glycine

1994 • 30 citations

Introduction and Symposium Overview

1992 • 14 citations

Advances in pharmacotherapy: recent developments in the treatment of epilepsy

1993 • 14 citations