Excitatory amino acid antagonists and their potential for the treatment of ischaemic brain damage in man.

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial.

1989 • 1,087 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

A Controlled Trial of Nimodipine in Acute Ischemic Stroke

1988 • 423 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

The Influence of Mild Body and Brain Hypothermia on Ischemic Brain Damage

1990 • 351 citations

Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations

1990 • 343 citations

Postischemic Blockade of AMPA but Not NMDA Receptors Mitigates Neuronal Damage in the Rat Brain following Transient Severe Cerebral Ischemia

1992 • 315 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission.

1990 • 298 citations

Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion.

1990 • 276 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats

1991 • 253 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Focal Cerebral Ischaemia in the Cat: Treatment with the Glutamate Antagonist MK-801 after Induction of Ischaemia

1988 • 244 citations

Excitatory amino acid antagonists

1991 • 240 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

Treatment of Experimental Cerebral Ischemia

1982 • 224 citations

CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.

1988 • 219 citations

Taking apart NMDA receptors

1987 • 209 citations

Direct Evidence That Excitotoxicity in Cultured Neurons Is Mediated via N‐Methyl‐D‐Aspartate (NMDA) as well as Non‐NMDA Receptors

1989 • 208 citations

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

1990 • 198 citations

The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model

1992 • 184 citations

The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection

1988 • 171 citations

Reduction of Infarct Volume by Magnesium after Middle Cerebral Artery Occlusion in Rats

1991 • 164 citations

N‐Methyl‐D‐Aspartate antagonist reduces stroke size and regional glucose metabolism

1990 • 155 citations

Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

1989 • 154 citations

The pharmacotherapy of focal cortical ischaemia in the mouse

1990 • 151 citations

Correlation of the extracellular glutamate concentration with extent of blood flow reduction after subdural hematoma in the rat

1991 • 147 citations

Posthypoxic treatment with MK‐801 reduces hypoxic‐ischemic damage in the neonatal rat

1989 • 146 citations

Ischemic Flow Threshold for Extracellular Glutamate Increase in Cat Cortex

1989 • 137 citations

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

1990 • 135 citations

Dextromethorphan reduces neocortical ischemic neuronal damage in vivo

1988 • 131 citations

7‐クロルキヌレン酸はN‐メチル‐D‐アスパラギン酸受容体複合体のグリシン調節部位での選択的きっ抗物質である

1988 • 130 citations

The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia

1991 • 128 citations

Combined therapy with MK‐801 and nimodipine for protection of ischemic brain damage

1991 • 118 citations

Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits.

1988 • 115 citations

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat

1990 • 112 citations

Focal Cerebral Ischemia in the Cat: Pretreatment with a Competitive NMDA Receptor Antagonist, D-CPP-ene

1990 • 111 citations

Synthesis and NMD A Antagonistic Properties of the Enantiomers of 4‐(3‐phosphonopropyl)piperazine‐2‐carboxylic acid (CPP) and of the unsaturated analogue (E)‐4‐(3‐phosphonoprop‐2‐enyl)piperazine‐2‐carboxylic acid (CPP‐ene)

1989 • 109 citations

Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use

1989 • 106 citations

The Effects of Dizocilpine Maleate (MK-801), an Antagonist of the N-Methyl-D-Aspartate Receptor, on Neurologic Recovery and Histopathology following Complete Cerebral Ischemia in Primates

1990 • 100 citations

The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia

1990 • 93 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

Neuroprotective effects of MK-801, TCP, PCP and CPP against N-methyl-d-aspartate induced neurotoxicity in an in vivo perinatal rat model

1989 • 84 citations

MK-801, an Excitatory Amino Acid Antagonist, Does Not Improve Neurologic Outcome following Cardiac Arrest in Cats

1989 • 67 citations

Evaluation of a competitive NMDA antagonist (<scp>D</scp>‐CPPene) in feline focal cerebral ischemia

1991 • 66 citations

The effects of dizocilpine (MK-801), phencyclidine, and nimodipine on infarct size 48 h after middle cerebral artery occlusion in the rat

1991 • 65 citations

Differential effects of competitive and non-competitive antagonists on glucose use in the limbic system

1988 • 63 citations

Protection after Transient Focal Cerebral Ischemia by the N-Methyl-d-Aspartate Antagonist Dextrorphan is Dependent upon Plasma and Brain Levels

1991 • 60 citations

Effect of MK-801 on focal brain infarction in normotensive and hypertensive rats.

1992 • 58 citations

Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology

1989 • 56 citations

Autoradiographic assessment of the effects of N-methyl-d-aspartate (NMDA) receptor antagonists in vivo

1991 • 56 citations

Effect of Excitatory Amino Acid Receptor Blocker MK-801 on Overall, Neurologic, and Morphologic Outcome after Prolonged Cardiac Arrest in Dogs

1989 • 49 citations

The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects

1989 • 41 citations

Autoradiographic analysis of 3H-MK-801 (dizocilpine) in vivo uptake and in vitro binding after focal cerebral ischemia in the rat

1992 • 34 citations

Les agents provocateurs: A series on the pharmacology of excitatory amino acids

1990 • 29 citations

Kynurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats

1990 • 19 citations

Tenth International Symposium on Cerebral Blood Flow and Metabolism

1982 • 4 citations