Emerging treatments for stroke in humans

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

1995 • 3,456 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

1989 • 1,231 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats

2024 • 898 citations

Fast magnetic resonance diffusion‐weighted imaging of acute human stroke

1992 • 882 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease.

1988 • 819 citations

Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging.

1996 • 743 citations

Delayed hippocampal damage in humans following cardiorespiratory arrest

1987 • 710 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Nimodipine treatment in poor-grade aneurysm patients

1988 • 527 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Low-Molecular-Weight Heparin for the Treatment of Acute Ischemic Stroke

1995 • 480 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

1991 • 382 citations

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

1992 • 361 citations

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

1994 • 360 citations

Delayed neuronal death in the rat hippocampus following transient forebrain ischemia

1984 • 349 citations

Postischemic Blockade of AMPA but Not NMDA Receptors Mitigates Neuronal Damage in the Rat Brain following Transient Severe Cerebral Ischemia

1992 • 315 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Oxygen Radicals in Focal Cerebral Ischemia

1994 • 263 citations

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial

1993 • 234 citations

Changes in Amino Acid Neurotransmitters and Cerebral Blood Flow in the Ischemic Penumbral Region following Middle Cerebral Artery Occlusion in the Rat: Correlation with Histopathology

1993 • 220 citations

Heat shock protects cultured neurons from glutamate toxicity

1991 • 199 citations

Glutamate‐Mediated Injury in Focal Cerebral Ischemia: The Excitotoxin Hypothesis Revised

1994 • 199 citations

Delayed Treatment with Intravenous Basic Fibroblast Growth Factor Reduces Infarct Size following Permanent Focal Cerebral Ischemia in Rats

1995 • 180 citations

The Complex Role of Nitric Oxide in the Pathophysiology of Focal Cerebral Ischemia

1994 • 176 citations

Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats

1994 • 153 citations

Experimental evidence of ischemic thresholds and functional recovery.

1992 • 153 citations

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.

1992 • 146 citations

Influence of granulocytopenia on canine cerebral ischemia induced by air embolism.

1989 • 139 citations

The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia

1991 • 128 citations

The Heat Shock/Stress Response in Focal Cerebral Ischemia

1994 • 114 citations

Calcium‐Mediated Mechanisms of Ischemic Injury and Protection

1994 • 108 citations

Recovery of Monkey Brain after Prolonged Ischemia. II. Protein Synthesis and Morphological Alterations

1986 • 98 citations

Chapter 2 Temperature modulation of ischemic brain injury - a synthesis of recent advances

1993 • 64 citations

Cerebrovascular Diseases: Nineteenth Princeton Stroke Conference

1995 • 33 citations

Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia.

1993 • 27 citations

Polyethylene Glycol-Conjugated Superoxide Dismutase Improves Recovery of Postischemic Hypercapnic Cerebral Blood Flow in Piglets

1993 • 23 citations

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