QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Chronic Fatigue Syndrome: A Working Case Definition

1988 • 1,710 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

1977 • 867 citations

Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

1991 • 705 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Excitatory Amino Acid Neurotransmission: NMDA Receptors and Hebb-Type Synaptic Plasticity

1988 • 484 citations

II. Excitotoxic models for neurodegenerative disorders

1984 • 469 citations

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1992 • 450 citations

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

1984 • 416 citations

NMDA Receptor Losses in Putamen from Patients with Huntington's Disease

1988 • 401 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Biological differences between ischemia, hypoglycemia, and epilepsy

1988 • 331 citations

l-Kynurenine Its synthesis and possible regulatory function in brain

1980 • 299 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.

1983 • 209 citations

Glutaric aciduria: Biochemical and morphologic considerations

1977 • 196 citations

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

1988 • 186 citations

Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.

1991 • 177 citations

Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

1989 • 175 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals

1990 • 131 citations

Neuroactive kynurenines in Lyme borreliasis

1992 • 125 citations

A Comprehensive Immunological Analysis in Chronic Fatigue Syndrome

1991 • 121 citations

Selective Loss of N‐Methyl‐d‐Aspartate‐Sensitive l‐[³H]Glutamate Binding Sites in Rat Brain Following Portacaval Anastomosis

1990 • 116 citations

Brain Quinolinic Acid in Huntington's Disease

1988 • 111 citations

Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1

1989 • 110 citations

Immune Activation and Decreased Tryptophan in Patients with HIV-1 Infection

1990 • 105 citations

Traumatic brain injuries: structural changes

1991 • 102 citations

Convulsant action of intracerebroventricularly administered l-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships

1982 • 96 citations

Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid

1992 • 95 citations

Response of Phosphopyruvate Carboxylase to Tryptophan Metabolites and Metal Ions

1971 • 92 citations

Increase in the Content of Quinolinic Acid in Cerebrospinal Fluid and Frontal Cortex of Patients with Hepatic Failure

1986 • 91 citations

Quinolinic acid phosphoribosyltransferase in human and rat brain: Activity in Huntington's disease and in quinolinate-lesioned rat striatum

1985 • 81 citations

Increased Cerebrospinal Fluid Quinolinic Acid, Kynurenic Acid, and L‐Kynurenine in Acute Septicemia

1990 • 80 citations

Rat 3‐Hydroxyanthranilic Acid Oxygenase: Purification from the Liver and Immunocytochemical Localization in the Brain

1987 • 80 citations

Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex

1989 • 76 citations

Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection

1988 • 75 citations

Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN-gamma-primed macrophages.

1990 • 69 citations

Hypothesis: A Role for Quinolinic Acid in the Neuropathology of Glutaric Aciduria Type I

1987 • 69 citations

Increase in Kynurenic Acid in Huntington's Disease Motor Cortex

1989 • 57 citations

Indole amine deficiency in blood and cerebrospinal fluid from patients with human immunodeficiency virus infection

1989 • 54 citations

Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central l-kynurenine administration

1990 • 54 citations

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

1991 • 49 citations

Interferon-γ-Induced Degradation of Tryptophan by Human Cells in vitro

1987 • 49 citations

Systemic Lipopolysaccharide and Pokeweed Mitogen Increase Quinolinic Acid Content of Mouse Cerebral Cortex

1988 • 41 citations

Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus

1987 • 33 citations

Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D

1990 • 32 citations

No changes in central quinolinic acid levels in Alzheimer's disease

1989 • 29 citations

Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus

1991 • 14 citations

Quinolinic acid: a modulator of the heart calcium channel in the rat and a binder of calcium ions

1991 • 11 citations

Quinolinic acid promotes the biochemical differentiation of cerebellar granule neurons

1990 • 2 citations