Schizophrenia: Some Current Neurochemical Approaches

CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA

1976 • 1,235 citations

[Biological psychiatry].

1980 • 1,087 citations

Amphetamine Psychosis: A "Model" Schizophrenia Mediated by Catecholamines

1973 • 590 citations

Lateral Cerebral Ventricular Enlargement in Chronic Schizophrenia

1979 • 579 citations

INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIA

1978 • 513 citations

Neuropathology of Schizophrenia

1982 • 472 citations

Schizophrenia: A New Approach

1952 • 469 citations

The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

1980 • 445 citations

Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms

1982 • 435 citations

The genetics of mental disorders

1971 • 419 citations

Increased Brain Dopamine and Dopamine Receptors in Schizophrenia

1982 • 393 citations

CEREBRAL VENTRICULAR SIZE IN TWINS DISCORDANT FOR SCHIZOPHRENIA

1982 • 313 citations

Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia

1973 • 300 citations

Central Dopamine Turnover in Schizophrenic Syndromes

1974 • 268 citations

Norepinephrine in Chronic Paranoid Schizophrenia: Above-Normal Levels in Limbic Forebrain

1978 • 265 citations

Neurotransmitter Receptors in Frontal Cortex of Schizophrenics

1979 • 249 citations

Phenylethylamine in Paranoid Chronic Schizophrenia

1979 • 221 citations

Elevation of brain neuroleptic/dopamine receptors in schizophrenia

1980 • 220 citations

Ventricular enlargement in schizophrenia: definition and prevalence

1982 • 215 citations

Folate-Responsive Homocystinuria and “Schizophrenia”

1975 • 214 citations

Monoamine Mechanisms in Chronic Schizophrenia: Post-Mortem Neurochemical Findings

1979 • 208 citations

INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIA

1979 • 203 citations

Prolactin Responses to Neuroleptics in Normal and Schizophrenic Subjects

1978 • 195 citations

Brain catecholamines in schizophrenia — a good case for noradrenaline

1982 • 186 citations

DIABETOGENIC NITROSAMINES?

1974 • 175 citations

Platelet Monoamine Oxidase Activity in Schizophrenia: A Review of the Data

1979 • 167 citations

3H-flupenthixol binding in post-mortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors

1981 • 165 citations

Schizophrenia in a North Swedish geographical isolate, 1900–1977. Epidemiology, genetics and biochemistry

1978 • 150 citations

Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders

1983 • 142 citations

Changes in rat striatal dopamine turnover and receptor activity during one years neuroleptic

1980 • 130 citations

POSSIBLE VIRUS IN SCHIZOPHRENIA AND SOME NEUROLOGICAL DISORDERS

1979 • 127 citations

Increased Whole Blood Serotonin Concentrations in Chronic Schizophrenic Patients

1981 • 121 citations

The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine

1976 • 120 citations

Ex uno multi: subtyping the schizophrenic syndrome.

1982 • 118 citations

Cerebral dopamine function in rats following withdrawal from one year of continuous neuroleptic administration

1980 • 116 citations

The Viral Hypothesis of Schizophrenia*

1976 • 116 citations

Human platelet monoamine oxidase activity in health and disease: a review.

1981 • 104 citations

IS SCHIZOPHRENIA AN INFECTIOUS DISEASE?

1983 • 102 citations

Low CSF 5-hydroxyindoleacetic acid in schizophrenic patients with enlarged cerebral ventricles

1983 • 102 citations

MASS FRAGMENTOGRAPHY OF PHENYLETHYLAMINE, m‐ AND p‐TYRAMINE AND RELATED AMINES IN PLASMA, CEREBROSPINAL FLUID, URINE, AND BRAIN

1979 • 97 citations

The Syndrome of Schizophrenia: Unresolved Questions and Opportunities for Research

1980 • 94 citations

Noradrenergic Overactivity in Chronic Schizophrenia: Evidence Based on Cerebrospinal Fluid Noradrenaline and Cyclic Nucleotide Concentrations

1980 • 91 citations

Increased noradrenaline levels in CSF and plasma of schizophrenic patients.

1982 • 88 citations

The Genetics and Biochemistry of Paranoid Schizophrenia and Other Paranoid Psychoses

1981 • 86 citations

The activities of brain dopamine-?-hydroxylase and catechol-O-methyl transferase in schizophrenics and controls

1978 • 81 citations

A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism

1978 • 78 citations

Blood Tryptophan Metabolism in Chronic Schizophrenics

1981 • 77 citations

Biological Homogeneity, Symptom Heterogeneity, and the Diagnosis of Schizophrenia*

1978 • 77 citations

Impaired Presynaptic Regulation of Norepinephrine in Schizophrenia

1982 • 76 citations

Brain tryptophan metabolism in schizophrenia: A post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects

1979 • 74 citations

Dopamine-Sensitive Adenylyl Cyclase in Human Caudate Nucleus

1975 • 73 citations

The effect of pimozide on CSF norepinephrine in schizophrenia

1981 • 73 citations

Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia

1982 • 67 citations

Post-mortem measurement of enzymes in human brain: Evidence of a central noradrenergic deficit in schizophrenia

1974 • 67 citations

Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects

1974 • 67 citations

Anterior pituitary hormone secretion in chronic schizophrenia – an approach to neurohumoral mechanisms

1977 • 64 citations

Neuroendocrine Effects of Apomorphine: Characterization of Response Patterns and Application to Schizophrenia Research

1979 • 64 citations

Factors Affecting Determination of Platelet Monoamine Oxidase Activity

1980 • 63 citations

Gamma-Aminobutyric Acid (GABA) in the CSF of Schizophrenic Patients Before and After Neuroleptic Treatment

1978 • 62 citations

SERUM DOPAMINE‐β‐HYDROXYLASE IN SCHIZOPHRENIC PATIENTS

1978 • 56 citations

CSF Levels of γ-Aminobutyric Acid in Schizophrenia

1982 • 52 citations

SCHIZOPHRENIA-LIKE PSYCHOSIS CAUSED BY A METABOLIC DISORDER

1980 • 52 citations

Platelet Monoamine Oxidase Activity in Acute Schizophrenia: Relationship to Symptomatology and Neuroleptic Medication

1981 • 51 citations

Prolactin-Releasing Effect of a Novel Anti-Dopaminergic Drug, Domperidone, in the Rat

1980 • 51 citations

Chronic continuous administration of neuroleptic drugs alters cerebral dopamine receptors and increases spontaneous dopaminergic action in the striatum

1982 • 48 citations

Plasma Norepinephrine and Dopamine-β-Hydroxylase Activity in Schizophrenia

1982 • 48 citations

SUBSTANCES RELATED TO 5‐HYDROXYTRYPTAMINE IN PLASMA AND IN LUMBAR AND VENTRICULAR FLUIDS OF PSYCHIATRIC PATIENTS

1980 • 45 citations

CLINICAL COURSE OF ADULT METACHROMATIC LEUKODYSTROPHY PRESENTING AS SCHIZOPHRENIA A REPORT OF TWO LIVING CASES IN SIBLINGS

1978 • 45 citations

Schizophrenia

1977 • 43 citations

γ‐Aminobutyric Acid Concentration in Cerebrospinal Fluid in Schizophrenia

1981 • 41 citations

The schizophrenia syndrome. Examples of biological tools for subclassification.

1981 • 41 citations

The Schizophrenia Syndrome

1981 • 37 citations

Increased Excretion of Dimethyltryptamine and Certain Features of Psychosis

1979 • 35 citations

BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS

1980 • 35 citations

Change in the characteristics of 3H-spiperone binding to rat striatal membranes after acute chlorpromazine administration: Effects of buffer washing of membranes

1979 • 34 citations

A Longitudinal Study of Urinary Excretion of N,N,-Dimethyltryptamine in Psychotic Patients

1980 • 30 citations

Methylation Hypothesis

1979 • 26 citations

Serum dopamine-beta-hydroxylase activity in schizophrenia.

1980 • 26 citations

Improved selective ion monitoring mass-spectrometric assay for the determination of n,n-dimethyltryptamine in human blood utilizing capillary column gas chromatography

1979 • 26 citations

CSF GABA in psychotic disorders

1980 • 23 citations

Biochemistry and the schizophrenia. Old concepts and new hypothesis.

1981 • 23 citations

Biochemistry and the Schizophrenias

1981 • 22 citations

Neurochemical investigations of the interaction of N,N-dimethyltryptamine with the dopaminergic system in rat brain

1977 • 21 citations

Twin Studies and Substrate Differences in Platelet Monoamine Oxidase Activity

1980 • 20 citations

Urinary Excretion of Dimethyltryptamine in Liver Disease

1979 • 20 citations

A Diagnostic Pointer to Adult Metachromatic Leucodystrophy

1980 • 17 citations

Increased synthesis of striatal dopamine by N,N-dimethyltryptamine

1977 • 15 citations

Neuroleptics attentuate stereotyped behavior induced by beta-phenylethylamine in rats.

1978 • 14 citations

Eine experimentelle Untersuchung zur bewußtseinsverändernden Wirkung von N,N-Dimethyltryptamin (DMT)

1976 • 12 citations

LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE

1978 • 11 citations

Biological Studies of DSM-III Psychotic Disorders. I. Platelet Measures and Apomorphine-induced Growth Hormone Response

1982 • 9 citations

An endogenous inhibitor of indoleamine-N-methyltransferase in cerebrospinal fluid

1978 • 8 citations

Biochemical aspects of schizophrenia.

1980 • 3 citations