Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

CLONAL GROWTH OF MAMMALIAN CELLS IN VITRO

1956 • 1,130 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Mouse myelomas and lymphomas in culture

1970 • 559 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

[11] Measurement of growth and viability of cells in culture

1979 • 517 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

[72] Identification of regulatory elements of cloned genes with functional assays

1987 • 477 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*

1987 • 363 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

1984 • 278 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation

1987 • 260 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts

1985 • 229 citations

Characterization of a glucocorticoid-sensitive human lymphoid cell line.

1977 • 217 citations

Genetic Approaches to Steroid Hormone Action

1976 • 203 citations

Rescue of thymocytes and T cell hybridomas from glucocorticoid‐induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire

1991 • 199 citations

Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells.

1981 • 190 citations

Glucocorticoid Receptor-Like Antigen in Lymphoma Cell Membranes: Correlation to Cell Lysis

1987 • 177 citations

Isolation of lymphoma cell variants resistant to killing by glucocorticoids

1974 • 176 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines

1977 • 170 citations

Gene activation is required for developmentally programmed cell death.

1990 • 160 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Functional Characterizations of the Androgen Receptor Confirm that the Molecular Basis of Androgen Action Is Transcriptional Regulation

1990 • 141 citations

Transcriptional inhibition by a glucocorticoid receptor-β-galactosidase fusion protein

1988 • 129 citations

A new mechanism for steroid unresponsiveness: Loss of nuclear binding activity of a steroid hormone receptor

1974 • 123 citations

Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks

1985 • 122 citations

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

1991 • 120 citations

Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer.

1986 • 106 citations

Quantitative analysis of the glucocorticoid receptor-DNA interaction at the mouse mammary tumor virus glucocorticoid response element.

1990 • 101 citations

Activation of covalent affinity labeled glucocorticoid receptor-steroid complexes.

1983 • 92 citations

Differentiated functions expressed by cultured mouse lymphoma cells

1970 • 91 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines.

1979 • 76 citations

Cellular receptor levels and glucocorticoid responsiveness of lymphoma cells

1984 • 72 citations

The Structure and Function of Steroid Receptor Protein

1989 • 70 citations

Characterization of wild type and mutant glucocorticoid receptors from rat hepatoma and mouse lymphoma cells.

1985 • 64 citations

Molecular genetics of corticosteroid action.

1990 • 49 citations

Mapping the human glucocorticoid receptor for leukemic cell death

1991 • 48 citations

Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter.

1991 • 47 citations

nti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain.

1990 • 47 citations

Metabolic and ultrastructural aspects of the in vitro lysis of chronic lymphocytic leukemia cells by glucocorticoids.

1982 • 45 citations

Genetic and Epigenetic Bases of Glucocorticoid Resistance in Lymphoid Cell Lines

1985 • 31 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus

1984 • 30 citations

Glucocorticoid-resistant lymphoma cell variants that contain functional glucocorticoid receptors.

1987 • 30 citations

The truncated glucocorticoid receptor in the P1798 mouse lymphosarcoma is associated with resistance to glucocorticoid lysis but not to other glucocorticoid-induced functions.

1991 • 16 citations

Immunochemical comparison of mutant glucocorticoid receptors and wild type receptor fragments produced by neutrophil elastase and chymotrypsin

1987 • 12 citations

Glucocorticoid-Resistant Lymphoma Cell Variants That Contain Functional Glucocorticoid Receptors

1987 • 10 citations

Gene activation is required for developmentally programmed cell death.

1990 • 8 citations

Characterization of glucocorticoid receptors in S49 mouse lymphoma cells by affinity labeling with [3H]dexamethasone 21-mesylate

1987 • 8 citations

Transfection of a T-cell line with neo increases dexamethasone cytotoxicity

1990 • 5 citations