Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

Adhesion receptors of the immune system

1990 • 6,585 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing

1987 • 1,134 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

A thousand and one protein kinases

1987 • 1,066 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

The Neural Cell Adhesion Molecule (NCAM) as a Regulator of Cell-Cell Interactions

1988 • 790 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

THE MEMBRANE SKELETON OF HUMAN ERYTHROCYTES AND ITS IMPLICATIONS FOR MORE COMPLEX CELLS

1985 • 673 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Protein phosphatases come of age

1989 • 616 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia

1990 • 566 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Morphoregulatory molecules

1988 • 460 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

1989 • 427 citations

Demonstration that the leukocyte common antigen (CD45) is a protein tyrosine phosphatase

1988 • 425 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

CELL ADHESION AND THE MOLECULAR PROCESSES OF MORPHOGENESIS

1985 • 400 citations

Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.

1991 • 393 citations

Protein phosphatases: recent progress.

1991 • 391 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

1987 • 357 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.

1990 • 336 citations

Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins

1985 • 331 citations

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

1990 • 328 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.

1989 • 313 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

The epidermal growth factor receptor as a multifunctional allosteric protein

1988 • 286 citations

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

1988 • 282 citations

A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.

1988 • 277 citations

Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

1981 • 277 citations

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

1989 • 276 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Control of glycogen synthase by hierarchal protein phosphorylation

1990 • 266 citations

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

1988 • 257 citations

Interconvertible Enzyme Cascades in Cellular Regulation

1980 • 257 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Phosphotyrosyl protein phosphatases

1989 • 239 citations

Structural variants of human T200 glycoprotein (leukocyte-common antigen).

1987 • 239 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Molecular analysis of signal transduction by growth factors

1988 • 224 citations

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

1988 • 223 citations

Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

1990 • 223 citations

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast

1990 • 221 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

Cloning and expression of a protein-tyrosine-phosphatase.

1990 • 215 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

Synergistic phosphorylation and activation of ATP-Mg-dependent phosphoprotein phosphatase by F A/GSK-3 and casein kinase II (PC0.7).

1984 • 212 citations

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

1991 • 207 citations

Phosphorylase and the Control of Glycogen Degradation* *The authors wish to thank the National Institutes of Arthritis and Metabolic Disease, NIH, United States Public Health Service (AM 07902), the National Science Foundation (GN 5932X), and the Muscular Dystrophy Association of America for support during preparation of this review.

1971 • 201 citations

Phosphotyrosyl-protein phosphatase of TCRC-2 cells.

1982 • 195 citations

A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.

1991 • 192 citations

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.

1990 • 191 citations

ATP x Mg-dependent protein phosphatase from rabbit skeletal muscle. I. Purification of the enzyme and its regulation by the interaction with an activating protein factor.

1980 • 188 citations

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

1982 • 183 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Xenopus oocytes and the biochemistry of cell division

1990 • 182 citations

Cloning and expression of a widely expressed receptor tyrosine phosphatase.

1990 • 180 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Complementation of the Mitotic Activator, p80 ^cdc25 , by a Human Protein-tyrosine Phosphatase

1990 • 178 citations

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.

1990 • 175 citations

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.

1990 • 174 citations

Superiority of interconvertible enzyme cascades in metabolic regulation: Analysis of multicyclic systems

1977 • 173 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.

1988 • 166 citations

CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity.

1990 • 163 citations

Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions.

1990 • 158 citations

Characterisation of a Reconstituted Mg‐ATP‐Dependent Protein Phosphatase

1983 • 154 citations

Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

1990 • 151 citations

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain.

1990 • 149 citations

Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus.

1986 • 149 citations

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.

1990 • 148 citations

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck.

1990 • 142 citations

Interconvertible Enzyme Cascades in Metabolic Regulation

1978 • 135 citations

Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells.

1990 • 132 citations

Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr

1985 • 132 citations

Spk1, a New Kinase from Saccharomyces cerevisiae, Phosphorylates Proteins on Serine, Threonine, and Tyrosine

1991 • 130 citations

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

1991 • 128 citations

A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin.

1985 • 119 citations

Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts.

1983 • 118 citations

Protein tyrosine dephosphorylation and signal transduction

1989 • 118 citations

Separation of multiple phosphotyrosyl-and phosphoseryl-protein phosphatases from chicken brain.

1983 • 114 citations

8 Phosphoprotein Phosphatases

1986 • 112 citations

B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.

1987 • 105 citations

Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity.

1990 • 101 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

Effect of Microinjection of a Low-M_r Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes

1990 • 99 citations

Cytosolic protein phosphotyrosine phosphatases from rabbit kidney. Purification of two distinct enzymes that bind to Zn2+-iminodiacetate agarose.

1984 • 96 citations

A tumor promoter stimulates phosphorylation on tyrosine

1983 • 92 citations

Identification of inhibitor-2 as the ATP-mg-dependent protein phosphatase modulator.

1981 • 90 citations

Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes

1990 • 85 citations

Phosphorylase phosphatase. Interconversion of active and inactive forms.

1984 • 83 citations

Stimulation of protein phosphatase activity by insulin and growth factors in 3T3 cells.

1988 • 83 citations

Regulation of ATP, Mg-Dependent Protein Phosphatases

1988 • 77 citations

Regulation of ATP—Mg-Dependent Protein Phosphatase

1984 • 76 citations

Purification and Characterization of a 40 S Ribosomal Protein S6 Kinase from Vanadate-stimulated Swiss 3T3 Cells

1989 • 76 citations

The phosphocreatine shuttle of sea urchin sperm: flagellar creatine kinase resulted from a gene triplication.

1990 • 73 citations

Phosphotyrosyl-protein phosphatases

1989 • 63 citations

Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells

1982 • 60 citations

Phosphorylation of smooth muscle caldesmon by calmodulin-dependent protein kinase II. Identification of the phosphorylation sites.

1990 • 57 citations

Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase

1988 • 57 citations

Rapid calculation of the solution scattering profile from a macromolecule of known structure

1989 • 56 citations

Phosphorylation and Dephosphorylation of Glycogen Phosphorylase: A Prototype for Reversible Covalent Enzyme Modification

1981 • 54 citations

Major Substrate for Growth Factor-Activated Protein-Tyrosine Kinases Is a Low-Abundance Protein

1985 • 54 citations

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.

1991 • 50 citations

Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors

1988 • 49 citations

Effect of various excitatory agonists on the secretion of 5‐hydroxytryptamine from permeabilised human platelets induced by Ca²⁺ in the presence or absence of GTP

1985 • 47 citations

Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: Partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase

1983 • 44 citations

Conversion of active protein phosphatase to the ATP‐Mg‐dependent enzyme form by inhibitor‐2

1981 • 42 citations

Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.

1990 • 41 citations

Cloning and chromosomal assignment of a widely expressed human receptor‐like protein‐tyrosine phosphatase

1990 • 38 citations

Protein tyrosine phosphatase domains from the protochordate Styela plicata

1991 • 37 citations

Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments

1987 • 36 citations

Kinase FA-mediated regulation of rabbit skeletal muscle protein phosphatase. Reversible phosphorylation of the modulator subunit.

1985 • 34 citations

The Viral Tyrosine Protein Kinases

1986 • 31 citations

Phosphotyrosyl-protein phosphatases

1989 • 26 citations

Subunit Structure and Regulation of Phosphorylase Phosphatase

1985 • 25 citations

Further characterization of a fodrin-containing transmembrane complex from mouse T-lymphoma cells

1987 • 25 citations

Protein phosphorylation as a regulatory device

1983 • 20 citations

An Unusual Form of Lipid Linkage to the CD45 Peptide

1990 • 14 citations

On the dephosphorylation of the ATP,Mg‐dependent protein phosphatase modulator

1987 • 5 citations