Cytokines in T-cell development

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

The generation and fate of thymocytes.

1990 • 309 citations

Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues.

1988 • 271 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

Developmental Biology of T Cell Receptors

1989 • 223 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

1987 • 215 citations

Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*

1989 • 186 citations

IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets

1989 • 180 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

Murine thymocytes proliferate in direct response to interleukin-7

1989 • 157 citations

Interleukin 7: effects on early events in lymphopoiesis

1989 • 140 citations

Human thymic epithelial cells produce interleukin 1.

1987 • 136 citations

Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.

1984 • 131 citations

Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors

1987 • 124 citations

Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse.

1988 • 120 citations

IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing alpha beta or gamma delta T-cell receptors in vitro: synergism with IL-2.

1989 • 119 citations

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

1990 • 116 citations

Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2

1985 • 108 citations

lnterleukin-2-dependent autocrine proliferation in T-cell development

1989 • 107 citations

Transforming growth factor-βs are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation

1988 • 106 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.

1988 • 97 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

Recombinant interleukin 4/BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro.

1987 • 87 citations

Interleukin 4 expressed in situ selectively alters thymocyte development.

1991 • 86 citations

Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.

1990 • 84 citations

The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.

1988 • 81 citations

Requirements for growth of immature thymocytes from fetal and adult mice in vitro

1986 • 78 citations

Thymic reticulum in mice III. Phagocytic cells of the thymic reticulum in culture secrete both prostaglandin E₂ and interleukin 1 which regulate thymocyte proliferation

1983 • 77 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation.

1987 • 70 citations

Early genetic events in T cell development analyzed by in situ hybridization.

1987 • 68 citations

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

1988 • 65 citations

Detection of Thy‐1, T‐200, Lyt‐1 and Lyt‐2‐bearing cells in the developing lymphoid organs of the mouse embryo in vivo and in vitro

1982 • 64 citations

Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells.

1990 • 63 citations

CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells.

1989 • 62 citations

Functional status of interleukin 2 receptors expressed by immature (Lyt-2-/L3T4-) thymocytes.

1986 • 60 citations

Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

1990 • 58 citations

Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes.

1986 • 57 citations

Tumor necrosis factor-alpha and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2.

1990 • 54 citations

Expression of interleukin 2 receptor on murine fetal thymocytes

1985 • 53 citations

Early events in T lymphocyte genesis in the fetal thymus

1984 • 53 citations

I-A-positive nonlymphoid cells and T cell development in murine fetal thymus organ cultures: interleukin 1 circumvents the block in T cell differentiation induced by monoclonal anti-I-A antibodies.

1986 • 51 citations

Thymic factors and T cell maturation in vitro: a comparison of the effects of thymic epithelial cultures with thymic extracts and thymus dependent serum factors.

1979 • 50 citations

Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway.

1988 • 50 citations

Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes.

1987 • 50 citations

Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells.

1989 • 49 citations

IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.

1990 • 48 citations

Selective expression of CD45 isoforms and of maturation antigens during human thymocyte differentiation: observations and hypothesis

1989 • 46 citations

Development of fetal thymocytes in organ cultures. Effect of interleukin 2.

1987 • 42 citations

Role of interleukin 1 in early T cell development: Lyt-2-L3T4- thymocytes bind and respond in vitro to recombinant IL 1.

1986 • 42 citations

Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition.

1985 • 41 citations

Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures.

1990 • 37 citations

Murine CD2 gene expression during fetal thymus ontogeny

1988 • 35 citations

IL-2 receptor inducibility is blocked in cortical-type thymocytes.

1988 • 35 citations

Mouse fetal thymus lobes cultured in IL-2 generate CD3+, TCR-gamma delta-expressing CD4-/CD8+ and CD4-/CD8- cells.

1989 • 31 citations

A role for interleukin 4 in the differentiation of mature T cell receptor gamma/delta + cells from human intrathymic T cell precursors.

1990 • 31 citations

Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

1989 • 30 citations

Changes in inducibility of IL-2 receptor alpha-chain and T cell-receptor expression during thymocyte differentiation in the mouse.

1989 • 29 citations

Up-regulation of interleukin 4 receptor expression on immature (Lyt-2-/L3T4-) thymocytes.

1988 • 29 citations

Differentiation of human mature thymocytes: Existence of a T3⁺4⁻8⁻ intermediate stage

1986 • 29 citations

Differentiation of thymocytes in fetal organ culture: lack of evidence for the functional role of the interleukin 2 receptor expressed by prothymocytes

1988 • 28 citations

Thymic stroma-derived T cell growth factor (TSTGF). I. Functional distinction of TSTGF from interleukins 2 and 4 and its preferential growth-promoting effect on helper T cell clones.

1987 • 26 citations

IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes.

1989 • 26 citations

Developmentally controlled expression of IL 2 receptors and of sensitivity to IL 2 in a subset of embryonic thymocytes.

1985 • 25 citations

The effects of anti‐CD2 antibodies on the differentiation of mouse thymocytes

1989 • 25 citations

Activation of the interleukin 2 pathway precedes CD3‐T cell receptor expression in thymic development. Differential growth requirements of early and mature intrathymic subpopulations

1989 • 20 citations

IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2.

1988 • 17 citations

Differential Effects of IL-2 and IL-6 on the Development of Three Distinct Precursor T-Cell Populations in the Thymus

1990 • 11 citations

Analysis of T-cell subpopulations in human IL-2Rα transgenic mice: Expansion of Thy1.2- thymocytes and depletion of double-positive T-cell precursors

1989 • 10 citations

Clonogenic potential of murine CD4+8+ thymocytes. Direct demonstration using a V beta 6-specific proliferative stimulus in Mlsa mice.

1989 • 7 citations

Responsiveness of fetal and adult CD4-, CD8- thymocytes to T cell activation.

1989 • 6 citations

Cytokines and development

1990 • 1 citations

Mouse foetal thymus development

1990 • 1 citations