Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

1992 • 379 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes.

1985 • 300 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

1983 • 253 citations

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1992 • 243 citations

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1983 • 225 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.

1993 • 205 citations

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14

1986 • 197 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.

1993 • 177 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Evidence for three types of human cytotoxic lymphocyte

1986 • 149 citations

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

1993 • 146 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts.

1993 • 136 citations

Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.

1980 • 133 citations

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1988 • 130 citations

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

1988 • 117 citations

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.

1992 • 117 citations

Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target.

1982 • 113 citations

THE STRONG CORRELATION OF CYTOTOXIC T LYMPHOCYTE-SPECIFIC SERINE PROTEASE GENE TRANSCRIPTS WITH RENAL ALLOGRAFT REJECTION1,2

1992 • 104 citations

The Isolation and Characterization of a Family of Serine Protease Genes Expressed in Activated Cytotoxic T Lymphocytes

1988 • 95 citations

The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.

1991 • 87 citations

Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide.

1993 • 81 citations

Proteases and lymphocyte cytotoxic killing mechanisms

1993 • 72 citations

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.

1990 • 65 citations

A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor α- and δ-chain genes on mouse chromosome 14

1990 • 58 citations

Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.

1992 • 58 citations

Globin gene expression in erythroid human fetal liver cells.

1989 • 57 citations

Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.

1991 • 57 citations

Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes

1989 • 45 citations

In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

1991 • 44 citations

The 5'-flanking region of the human CGL-1/granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice.

1991 • 43 citations

Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene

1993 • 40 citations

Proximity of the CTLA-1 serine esterase and Tcr ? loci in mouse and man

1988 • 39 citations

Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII

1988 • 39 citations

Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.

1990 • 37 citations

Structural organization of the hCTLA-1 gene encoding human granzyme B

1990 • 29 citations

Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3- dependent murine stem cell lines

1992 • 27 citations

Cytotoxic effector cells of the immune system

1989 • 25 citations

Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes

1990 • 23 citations

Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin

1992 • 21 citations

ENDOMYOCARDIAL BIOPSIES AFTER HEART TRANSPLANTATION

1993 • 19 citations

The Granule Exocytosis Model for Lymphocyte Cytotoxicity and Its Relevance to Target Cell DNA Breakdown

1993 • 4 citations