Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

The p53 tumour suppressor gene

1991 • 3,871 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

p53 function and dysfunction

1992 • 1,918 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

1988 • 342 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Interferon-activated genes

1986 • 301 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene

1985 • 216 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1991 • 201 citations

Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells.

1990 • 159 citations

Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.

1991 • 155 citations

Improved mammalian vectors for high expression of G418 resistance.

1987 • 117 citations

Wilms' tumour: reconciling genetics and biology

1992 • 107 citations

Antitumor Effects of Interferon

1989 • 87 citations

Cytokine Gene Regulation: Regulatory cis-Elements and DNA Binding Factors Involved in the Interferon System

1992 • 87 citations

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.

1991 • 86 citations

Molecular Diagnostics of Human Cancer

1989 • 83 citations

Interferon-Dependent Signaling Pathways: DNA Elements, Transcription Factors, Mutations, and Effects of Viral Proteins

1992 • 80 citations

Induction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibition.

1983 • 79 citations

Expression of the 2-5A system druing the cell cycle

1985 • 77 citations

The Genetics of Wilms' Tumor

1992 • 73 citations

Multimerization of AAGTGA and GAAAGT generates sequences that mediate virus inducibility by mimicking an interferon promoter element.

1991 • 59 citations

Distinct activation of murine interferon-αpromoter region by IRF-1/ISFG-2 and virus infection

1992 • 47 citations

Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23–q31

1991 • 46 citations

Rapid and Transient Decrease of N-myc Expression in Retinoic Acid-Induced Differentiation of 0TF9 Teratocarcinoma Stem Cells

1990 • 31 citations

Isolation of heat- and cold-sensitive mutants of chinese hamster lung cells affected in their ability to express the transformed state

1975 • 22 citations

[31] Use of nude mice for tumorigenicity testing and mass propagation

1979 • 19 citations