The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Rapid and efficient cosmid cloning

1981 • 1,897 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1983 • 730 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

glp-1 Is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans

1987 • 684 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

1988 • 573 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Multiple Recurrent Genomic Defects in Follicular Lymphoma

1987 • 535 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

The C. elegans genome sequencing project: a beginning

1992 • 496 citations

Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.

1991 • 463 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

Integrative transformation of Caenorhabditis elegans

1986 • 417 citations

Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans s

1983 • 389 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

A uniform genetic nomenclature for the nematode Caenorhabditis elegans

1979 • 382 citations

glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins

1989 • 345 citations

Interleukin 1: the first interleukin

1990 • 342 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Evidence for a transposon in caenorhabditis elegans

1983 • 257 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis

1990 • 216 citations

unc-93(e1500): A BEHAVIORAL MUTANT OF CAENORHABDITIS ELEGANS THAT DEFINES A GENE WITH A WILD-TYPE NULL PHENOTYPE

1980 • 190 citations

There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas

1985 • 178 citations

The product of fem-1, a nematode sex-determining gene, contains a motif found in cell cycle control proteins and receptors for cell-cell interactions

1990 • 176 citations

Two C. elegans genes control the programmed deaths of specific cells in the pharynx

1991 • 171 citations

A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.

1989 • 149 citations

Presence of the Caenorhabditis elegans spliced leader on different mRNAs and in different genera of nematodes.

1988 • 142 citations

LETHALS, STERILES AND DEFICIENCIES IN A REGION OF THE X CHROMOSOME OF CAENORHABDITIS ELEGANS

1979 • 126 citations

Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus

1989 • 91 citations

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

1989 • 91 citations

The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.

1990 • 71 citations

Partial inhibition of castration induced ventral prostate regression with actinomycin D and cycloheximide.

1978 • 55 citations