CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.

1992 • 93 citations

Role of CD4 in thymocyte selection and maturation.

1989 • 88 citations

Co-engagement of CD8 with the T cell receptor is required for negative selection

1991 • 85 citations

Preferential positive selection of V_α2⁺CD8⁺ T cells in mouse strains expressing both H‐2^k and T cell receptor V_α^a haplotypes: determination with a V_α2‐specific monoclonal antibody

1992 • 81 citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

1991 • 81 citations

Engagement of CD4 and CD8 accessory molecules is required for T cell maturation.

1989 • 70 citations

CD8 is required during positive selection of CD4-/CD8+ T cells.

1990 • 65 citations

Evidence for CD8-independent T cell maturation in transgenic mice.

1990 • 53 citations