The CD8 coreceptor revisited: One chain good, two chains better

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

1993 • 274 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Inability of CD8α′polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo

1989 • 183 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Expression of different CD8 isoforms on distinct human lymphocyte subpopulations

1991 • 159 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

The MHC-Binding and gp120-Binding Functions of CD4 Are Separable

1989 • 151 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

Crystal Structure of Domains 3 and 4 of Rat CD4: Relation to the NH₂-Terminal Domains

1993 • 142 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

1992 • 94 citations

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.

1992 • 93 citations

Association of CD8 with p56lck is required for early T cell signalling events.

1991 • 79 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

An immunological role for the CD8 β-chain

1992 • 76 citations

A role for the cytoplasmic tail of the β chain of CD8 in thymic selection

1994 • 70 citations

Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association

1993 • 63 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

The lack of CD8α cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8⁺ T lymphocytes

1993 • 52 citations

T cell activation results in physical modification of the mouse CD8 beta chain.

1994 • 52 citations

Beta-chain broadens range of CD8 recognition for MHC class I molecule.

1992 • 48 citations

Distinct Functions of CD8(CD4) are Utilized at Different Stages of T‐Lymphocyte Differentiation

1989 • 35 citations

CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.

1991 • 30 citations

The cysteine residues in the cytoplasmic tail of CD8 α are required for its coreceptor function

1993 • 20 citations

A CD8 polypeptide that is lost after passing the Golgi but before reaching the cell surface: a novel sorting mechanism.

1988 • 20 citations

Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region.

1993 • 20 citations