The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

Septic Shock in Humans

1990 • 1,170 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria

1989 • 852 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

1985 • 620 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

1989 • 567 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.

1989 • 307 citations

Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

1989 • 278 citations

In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects.

1991 • 262 citations

Compartmentalization of Intraalveolar and Systemic Lipopolysaccharide-Induced Tumor Necrosis Factor and the Pulmonary Inflammatory Response

1989 • 244 citations

Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide

1989 • 220 citations

Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism.

1990 • 217 citations

Anticachectin/tumor necrosis factor‐α antibodies attenuate development of cachexia in tumor models

1989 • 210 citations

Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: The role of cachectin (tumor necrosis factor)

1985 • 205 citations

THE PRODUCTION OF TUMOR NECROSIS FACTOR ALPHA AND THE DEVELOPMENT OF A PULMONARY CAPILLARY INJURY FOLLOWING HEPATIC ISCHEMIA/REPERFUSION

1990 • 193 citations

In vitro Studies of Single Isolated Beating Heart Cells

1960 • 180 citations

Circulating tumour necrosis factor‐α (cachectin) in myocardial infarction

1989 • 172 citations

Role of TNF and IL-1 in infections with Toxoplasma gondii.

1990 • 170 citations

A Circulating Myocardial Depressant Substance is Associated with Cardiac Dysfunction and Peripheral Hypoperfusion (Lactic Acidemia) in Patients with Septic Shock

1989 • 166 citations

Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.

1988 • 161 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Pentoxifylline Prevents Tumor Necrosis Factor-induced Lung Injury

1989 • 122 citations

Evidence for IL-6 production by and effects on the pancreatic beta-cell.

1989 • 121 citations

Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals.

1988 • 119 citations

I. EVIDENCE THAT ELEVATED LEVELS OF TUMOR NECROSIS FACTOR-ALPHA PREDICT REJECTION FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1990 • 118 citations

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression.

1990 • 109 citations

Constitutive synthesis of tumor necrosis factor in the thymus.

1992 • 93 citations

Inhibition of Glucose Transport into Rat Islet Cells by Immunoglobulins from Patients with New-Onset Insulin-Dependent Diabetes Mellitus

1990 • 87 citations

Endotoxin-induced cytokine gene expression in vivo. I. Expression of tumor necrosis factor mRNA in visceral organs under physiologic conditions and during endotoxemia.

1989 • 79 citations

Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

1988 • 78 citations

Alternative Cleavage of the Cachectin/Tumor Necrosis Factor Propeptide Results in a Larger, Inactive Form of Secreted Protein

1989 • 75 citations

Right ventricular dysfunction in patients with septic shock

1988 • 72 citations

Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.

1992 • 71 citations

Method for preparation of glomeruli for metabolic studies.

1968 • 70 citations

A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.

1991 • 56 citations

Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis

1990 • 52 citations

Raised plasma levels of tumor necrosis factor in heart allograft rejection.

1990 • 48 citations

Enhanced Production of Monokines by Canine Alveolar Macrophages in Response to Endotoxin-Induced Shock

1988 • 40 citations

Role of tumor necrosis factor alpha (cachectin) in experimental and clinical bacterial meningitis

1989 • 30 citations

Prostaglandins E2 and I2, interleukin 1-beta, and tumor necrosis factor in cerebrospinal fluid of infants and children with bacterial meningitis

1989 • 23 citations

Tumor necrosis factor enhances interferon-induced Ia antigen expression on murine islet parenchymal cells.

1988 • 21 citations

TNF-alpha is expressed on the surface of kidney proximal tubular cells.

1991 • 13 citations