High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

Quantitative or semi-quantitative PCR: reality versus myth.

1992 • 351 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

1994 • 253 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats

1992 • 196 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions

1992 • 166 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria.

1994 • 91 citations

Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice

1994 • 82 citations

Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA

1994 • 77 citations

Detection of deletions in the mitochondrial genome ofCaenorhabditis elegans

1994 • 75 citations

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

1994 • 69 citations

Mitochondrial DNA diseases: Histological and cellular studies

1994 • 65 citations

Direct repeat sequences are not required at the breakpoints of age-associated mitochondrial DNA deletions in rhesus monkeys

1994 • 33 citations

Mitochondrial myopathy: correlation between oxidative defect and mitochondrial DNA deletions at single fiber level

1994 • 19 citations

Improved single-stranded DNA producing expression vectors for protein manipulation inEscherichia coli

1990 • 11 citations