Oxidative Stress Hypothesis in Alzheimer's Disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Oxidative stress, inflammation, and cancer: How are they linked?

2010 • 4,615 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

2009 • 3,191 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

2005 • 2,419 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Uber eine eigenartige Erkrankung der Hirnrinde

1907 • 1,332 citations

DISEASES OF THE NERVOUS SYSTEM

1918 • 1,308 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Oxidative stress and cancer: have we moved forward?

2006 • 1,269 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix

1989 • 1,056 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment

1990 • 950 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

Mechanism of Oxidative Stress in Neurodegeneration

2012 • 855 citations

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

1996 • 817 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins

1981 • 754 citations

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

1999 • 748 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

1996 • 533 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Neurodegenerative Diseases

1994 • 492 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

1992 • 474 citations

Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?

1989 • 471 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs

1995 • 460 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Free radicals in brain metabolism and pathology

1993 • 443 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

2009 • 406 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

1988 • 381 citations

Redox-active iron mediates amyloid-β toxicity

2001 • 376 citations

DRUG TREATMENT IN PSYCHIATRY

1964 • 372 citations

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

2009 • 368 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Microglia: Activation and Their Significance in the Central Nervous System

2001 • 353 citations

Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain

1995 • 352 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions

1995 • 333 citations

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

1994 • 321 citations

A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

2000 • 314 citations

Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts

1985 • 313 citations

Oxidative Stress in Neurodegeneration

2011 • 277 citations

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

1994 • 271 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

ALZHEIMERʼS DISEASE

1953 • 267 citations

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

1993 • 265 citations

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

2002 • 261 citations

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

1990 • 243 citations

Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

1999 • 240 citations

Regional brain trace-element studies in Alzheimer's disease.

1988 • 231 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

Amyloid β-protein toxicity and oxidative stress in Alzheimer's disease

1997 • 213 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

1995 • 209 citations

Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients

2001 • 204 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation

1994 • 202 citations

Evidence of an oxidative challenge in the Alzheimer's brain

1994 • 194 citations

Brain trace elements in Alzheimer's disease.

1986 • 194 citations

Selenium Level and Cognitive Function in Rural Elderly Chinese

2007 • 183 citations

Oxidative Glycation and Free Radical Production: A Causal Mechanism of Diabetic Complications

1991 • 179 citations

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease

2006 • 179 citations

A Mechanism for the Stimulatory Effect of Aluminum on Iron-Induced Lipid Peroxidation

1994 • 176 citations

Nutritional status of selenium in Alzheimer's disease patients

2009 • 173 citations

Free Radicals in the Genesis of Alzheimer's Diseasea

1993 • 171 citations

The relevance of oxidative stress status in first episode and recurrent depression

2012 • 171 citations

Vitamin C and Vitamin E for Alzheimer's Disease

2005 • 171 citations

Serum levels of the iron binding protein p97 are elevated in Alzheimer′s disease

1996 • 171 citations

Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics

2010 • 170 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

1994 • 166 citations

Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ

1995 • 165 citations

4-Hydroxynonenal inhibits Na+-K+-ATPase

1996 • 164 citations

Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

1990 • 164 citations

Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type

1985 • 161 citations

Diseases of the Nervous System: Clinical Neurobiology.

1988 • 159 citations

Pigments in Aging: An Overview

2002 • 157 citations

Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

2008 • 152 citations

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

1988 • 149 citations

Role of Nerve Growth Factor in Oxidanl Homeostasis: Glutathione Metabolism

1993 • 147 citations

Ferritin: isolation of aluminum-ferritin complex from brain.

1987 • 147 citations

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

2011 • 141 citations

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers

2012 • 141 citations

Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease

2008 • 140 citations

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin

1996 • 139 citations

Cellular toxicity and lipid peroxidation in response to mercury

1982 • 136 citations

Neurotransmitters, Drugs and Brain Function

2001 • 136 citations

The Expression of Key Oxidative Stress-Handling Genes in Different Brain Regions in Alzheimer's Disease

1998 • 136 citations

Cytochrome C Oxidase in Alzheimer's Disease Brain

1995 • 135 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

The mitochondrial electron transfer alteration as a factor involved in the brain aging

1992 • 132 citations

THE EPIDEMIOLOGY OF ALZHEIMER'S DISEASE

1986 • 127 citations

Oxidative stress in schizophrenia - focusing on the main markers.

2011 • 126 citations

The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense.

2001 • 116 citations

Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea

1996 • 116 citations

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

2007 • 114 citations

Elemental imbalances in the olfactory pathway in Alzheimer's disease

1995 • 113 citations

Effects of aluminum on brain lipid peroxidation

1990 • 112 citations

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1991 • 111 citations

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

1985 • 110 citations

PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways

1995 • 110 citations

Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases

1995 • 109 citations

Functional Alterations in Alzheimer's Disease: Selective Loss of Mitochondrial-encoded Cytochrome Oxidase mRNA in the Hippocampal Formation

1994 • 107 citations

Current Concepts of Excitotoxicity

1996 • 107 citations

Aging and the brain

1994 • 106 citations

Coenzyme Q10 Attenuates β-Amyloid Pathology in the Aged Transgenic Mice with Alzheimer Presenilin 1 Mutation

2008 • 102 citations

Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease

1994 • 98 citations

Neuronal and Vascular Oxidative Stress in Alzheimers Disease

2011 • 97 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure

1994 • 95 citations

Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease

1993 • 95 citations

Induction of Superoxide Anion and Nitric Oxide Production in Cultured Microglia^a

1994 • 94 citations

Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation

1996 • 93 citations

Morphometric Analysis of Microglia in Alzheimerʼs Disease

1993 • 91 citations

Functional Alterations in Alzheimerʼs Disease

1993 • 88 citations

The Treatment of Alzheimer Disease

2008 • 87 citations

Synaptic dysfunction and oxidative stress in Alzheimer's disease: Emerging mechanisms

2006 • 87 citations

The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration

2000 • 86 citations

In Vitro³¹P NMR Spectroscopy Detects Altered Phospholipid Metabolism in Alzheimer's Disease

1986 • 84 citations

Food additives as a source of behavioral disturbances in children.

1986 • 81 citations

Brain aluminum in Alzheimer's disease using an improved GFAAS method.

1992 • 77 citations

Age-related modifications of cytochrome c oxidase activity in discrete brain regions

1990 • 68 citations

Calcium and Free Radicals: Mediators of neurotrophic factor and excitatory transmitter-regulated developmental plasticity and cell death.

1996 • 68 citations

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

1994 • 64 citations

Mechanisms of Phospholipase A₂ Activation and Neuronal Injury

1993 • 60 citations

Mechanisms of the inhibitory effects of amyloid β-protein on synaptic plasticity

2004 • 59 citations

Selenium level and depressive symptoms in a rural elderly Chinese cohort

2012 • 58 citations

Brain glutathione peroxidase in neurodegenerative disorders

1986 • 57 citations

Corticotropin-releasing factor-like immunoreactivity in senile dementia of the Alzheimer type. Reduced cortical and striatal concentrations

1985 • 55 citations

Neurotrophic factor mediated protection from excitotoxicity and disturbances in calcium and free radical metabolism

1993 • 54 citations

Aluminosilicate-lnduced Free Radical Generation by Murine Brain Glial Cells in vitro: Potential Significance in the Aetiopathogenesis of Alzheimer's Dementia

1992 • 52 citations

Effects of serotonin depletion on behavior and neuronal oxidative stress status in rat: relevance for anxiety and affective disorders

2010 • 50 citations

Diseases of the Nervous System: Clinical Neurobiology

1993 • 46 citations

Brain Oxidative Energy and Related Metabolism, Neuronal Stress, and Alzheimer's Disease: A Speculative Synthesis

1993 • 46 citations

The interdependence of the reactive species of oxygen, nitrogen, and carbon

2012 • 45 citations

Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss!

2006 • 44 citations

Concentrations of several proteins characteristic of nervous tissue in cerebral cortex of patients with alzheimer’s disease

1991 • 40 citations

Oxidative Stress Induces Intralysosomal Accumulation of Alzheimer Amyloid β‐Protein in Cultured Neuroblastoma Cells

2006 • 35 citations

Effects of Ceruloplasmin on Superoxide-Dependent Iron Release from Ferritin and Lipid Peroxidation

1991 • 34 citations

Neutron Activation Analysis of Trace Elements in Motor Neuron Disease Spinal Cord

1995 • 33 citations

Markers of Oxidative Stress in Generalized Anxiety Psychiatric Disorder: Therapeutic Implications

2012 • 11 citations

[The effects of some cholinergic drugs on cognitive processes and oxidative stress in rat].

2010 • 9 citations

Deleted Work

1955 • 0 citations