Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

Basic local alignment search tool

1990 • 87,358 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Comprehensive organic chemistry

1978 • 2,831 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

The causes and prevention of cancer.

1995 • 1,326 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

1995 • 485 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

1996 • 435 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

1990 • 347 citations

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

1994 • 321 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

Unified catalytic mechanism for DNA glycosylases

1994 • 266 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

MutM, a protein that prevents G C→T A transversions, is formamidopyrimidine-DNA glycosylase

1991 • 210 citations

Characterization of a Mammalian Homolog of the Escherichia coli MutY Mismatch Repair Protein

1995 • 194 citations

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells.

1993 • 189 citations

NH2-terminal Proline Acts as a Nucleophile in the Glycosylase/AP-Lyase Reaction Catalyzed by Escherichia coli Formamidopyrimidine-DNA Glycosylase (Fpg) Protein

1997 • 177 citations

Base-specific reactions useful for DNA sequencing: methylene blue – sensitized photooxidation of guanine and osmium tetraoxide modification of thymine

1978 • 166 citations

Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine

1993 • 161 citations

Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli [formamidopyrimidine]DNA glycosylase

1989 • 157 citations

Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.

1996 • 153 citations

Evidence for an imino intermediate in the T4 endonuclease V reaction

1993 • 143 citations

Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

1996 • 138 citations

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase.

1993 • 136 citations

3‘- and 5‘-Strand Cleavage Reactions Catalyzed by the Fpg Protein from Escherichia coli Occur via Successive β- and δ-Elimination Mechanisms, Respectively

1996 • 114 citations

Difference in the expression level of DNA polymerase β among mouse tissues: High expression in the pachytene spermatocyte

1989 • 104 citations

Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA

1992 • 84 citations

An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA

1991 • 84 citations

Substrate Specificity of Escherichia coli MutY Protein

1996 • 80 citations

DNA containing a chemically reduced apurinic site is a high affinity ligand for theE.coliformamidopyrimidine-DNA glycosyiase

1992 • 62 citations

Testis and somaticXrcc-1 DNA repair gene expression

1994 • 49 citations

Formamidopyrimidine DNA glycosylase in the yeastSaccharomyces cerevisiae

1994 • 32 citations

Oxidative stress and antioxidants

2000 • 24 citations

A versatile support for the synthesis of oligonucleotides of extended length and scale

1994 • 12 citations