The Search for the Genetic Basis of Aging: The Identification of Gerontogenes in the Nematode Caenorhabditis elegans

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

ras GENES

1987 • 3,818 citations

Evolutionary biology of aging

1991 • 1,333 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER

1984 • 562 citations

Essays upon heredity and kindred biological problems

1889 • 458 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1983 • 427 citations

Handbook of the Biology of Aging

2005 • 413 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

Non-ageing developmental variant of Caenorhabditis elegans

1976 • 373 citations

Functional homology of mammalian and yeast RAS genes

1985 • 324 citations

Genetic analysis of life-span in Caenorhabditis elegans.

1982 • 302 citations

Biomarkers of aging

1988 • 286 citations

RESISTANCE TO ENVIRONMENTAL STRESS IN DROSOPHILA MELANOGASTER SELECTED FOR POSTPONED SENESCENCE

2004 • 270 citations

Handbook of the Biology of Aging

1991 • 259 citations

Three Mutants That Extend Both Mean and Maximum Life Span of the Nematode, Caenorhabditis Elegans, Define the Age-1 Gene

1988 • 239 citations

Mammalian and Yeast ras Gene Products: Biological Function in Their Heterologous Systems

1985 • 209 citations

Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.

1987 • 171 citations

Evidence from reversal of handedness in C. elegans embryos for early cell interactions determining cell fates

1991 • 166 citations

Arresting development arrests aging in the nematode Caenorhabditis elegans

1984 • 162 citations

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

1989 • 159 citations

The effects of gene-environment interaction on the expression of longevity

1985 • 148 citations

Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters

1981 • 130 citations

Review of Biological Research in Aging

1984 • 127 citations

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

1989 • 91 citations

Programmed aging or error catastrophe? An exmination by two-dimensional polyacrylamide gel electrophoresis

1985 • 66 citations

Prolongation of the yeast life span by the v‐Ha‐RAS oncogene

1990 • 56 citations

The morphology of postponed senescence in Drosophila melanogaster

1984 • 48 citations

Biology of developing systems

1978 • 46 citations

Invertebrate models in aging research

1985 • 35 citations

Patterns of proteins synthesized during development of Caenorhabditis elegans

1979 • 31 citations

Can an Index of Aging Be Constructed for Evaluating Treatments To Retard Aging Rates? A 2,462-Person Study

1990 • 29 citations

Quantitative measures of aging in the nematode caenorhabditis elegans: II. Lysosomal hydrolases as markers of senescence

1983 • 25 citations

Genetic specification of life span and self-fertility in recombinant-inbred strains of Caenorhabditis elegans

1991 • 25 citations

Alterations in Gene Expression with Aging

1990 • 23 citations

Genetic Specification of Life Span: Processes, Problems, and Potentials

1988 • 18 citations

Aging in Today's Environment

1987 • 13 citations

Early determinative events in Caenorhabditis elegans

1991 • 12 citations

Caenorhabditis elegans Offers the Potential for Molecular Dissection of the Aging Processes

1990 • 12 citations

Models for Biomedical Research.

1986 • 11 citations

Genetic and Environmental Manipulation of Aging in Caenorhabditis elegans

1987 • 9 citations