Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
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References (42)
Oxidants, antioxidants, and the degenerative diseases of aging.
1993 • 6,011 citations
Hydroperoxide metabolism in mammalian organs.
1979 • 5,821 citations
DNA Repair and Mutagenesis
2006 • 4,725 citations
Oxidative mechanisms in the toxicity of metal ions
1995 • 4,127 citations
Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
1989 • 3,477 citations
DNA repair and mutagenesis
1996 • 2,289 citations
Hydrogen peroxide mediates amyloid β protein toxicity
1994 • 2,065 citations
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
1994 • 2,025 citations
Oxidative damage and mitochondrial decay in aging.
1994 • 2,024 citations
Normal oxidative damage to mitochondrial and nuclear DNA is extensive.
1988 • 1,709 citations
REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology
1994 • 1,435 citations
DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability
1988 • 1,434 citations
Reactions of oxyl radicals with DNA
1995 • 1,041 citations
The oxidative inactivation of mitochondrial electron transport chain components and ATPase.
1990 • 718 citations
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
1994 • 617 citations
Cell and tissue responses to oxidative damage.
1993 • 492 citations
Interaction of lipid peroxidation products with DNA. A review
1988 • 455 citations
Differential regulation of antioxidant enzymes in response to oxidants.
1991 • 411 citations
Mitochondrial decay in aging
1995 • 398 citations
Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells
1992 • 269 citations
Repair of products of oxidative DNA base damage in human cells
1996 • 269 citations
Apoptosis: Molecular Control Point in Toxicity
1994 • 263 citations
Technologies for Detection of DNA Damage and Mutations
1996 • 246 citations
A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress
1995 • 242 citations
Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions
1991 • 240 citations
Mitochondrial DNA mutations in human degenerative diseases and aging
1995 • 224 citations
Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons
1994 • 208 citations
Lipid peroxidation in mitochondria
1988 • 185 citations
Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.
1993 • 175 citations
Evidence for mitochondrial DNA damage by lipid peroxidation
1988 • 160 citations
Efficient protection against oxidative DNA damage in chromatin
1992 • 135 citations
Thymine Fragment Damage Retained in the DNA Polynucleotide Chain after Gamma Irradiation in Aerated Solutions. II
1977 • 127 citations
Technologies for Detection of DNA Damage and Mutations
1997 • 108 citations
Mitochondrial DNA alterations as a source of human disorders
1993 • 86 citations
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions
1995 • 79 citations
Exposure to low concentrations of hydrogen peroxide causes delayed endothelial cell death and inhibits proliferation of surviving cells
1995 • 77 citations
Low-Level Oxidative Stress Causes Cell Cycle-Specific Arrest in Cultured Cells
1995 • 75 citations
DNA STRAND BREAKS IN MAMMALIAN CELLS EXPOSED TO LIGHT IN THE PRESENCE OF RIBOFLAVIN AND TRYPTOPHAN
1979 • 68 citations
Template integrity is essential for PCR amplification of 20- to 30-kb sequences from genomic DNA.
1995 • 66 citations
Lipid peroxidation and mtDNA degeneration. A hypothesis
1992 • 66 citations
Modeling and molecular mechanical studies of the cis-thymine glycol radiation damage lesion in DNA
1987 • 38 citations
Hydrogen peroxide release from human polymorphonuclear leukocytes measured with horseradish peroxidase and o-dianisidine. Effect of various stimulators and cytochalasin B.
1990 • 26 citations