Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Evolution of ageing

1977 • 1,784 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Evolution of senescence: late survival sacrificed for reproduction

1991 • 1,066 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

Mitochondrial role in cell aging

1980 • 919 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Metabolite Transport in Mitochondria

1979 • 618 citations

Hypervariable ultra-long telomeres in mice

1990 • 612 citations

GENETICS OF MITOCHONDRIAL BIOGENESIS

1986 • 420 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

The Turnover of Mitochondria in a Variety of Tissues of Young Adult and Aged Rats

1971 • 335 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.

1986 • 218 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

1983 • 197 citations

Reduced transcription of mitochondrial DNA in the senescent rat

1990 • 191 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Mapping of the protein import machinery in the mitochondrial outer membrane by crosslinking of translocation intermediates

1992 • 185 citations

Influence of Mitochondrial Radical Formation on Energy‐Linked Respiration

1978 • 168 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

Evidence for mitochondrial DNA damage by lipid peroxidation

1988 • 160 citations

Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.

1985 • 131 citations

Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123.

1981 • 117 citations

The effect of aging and acetyl-l-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria

1992 • 111 citations

Modification of mitochondrial respiration by aging and dietary restriction

1980 • 106 citations

Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria

1991 • 89 citations

Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain

1991 • 77 citations

Mitochondrial Volume in Skeletal Muscle from Young and Old Physically Untrained and Trained Healthy Men and from Alcoholics

1973 • 75 citations

Lipid changes with aging in cardiac mitochondrial membranes

1984 • 59 citations

Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala

1972 • 59 citations

Age-related changes in respiration coupled to phosphorylation. II. cardiac mitochondria

1988 • 55 citations

Oxidants and antioxidants in proliferative senescence

1991 • 48 citations

Age-related decline in the biosynthesis of mitochondrial inner membrane proteins

1982 • 40 citations

A new method for testing cell ageing using two mitochondria specific fluorescent probes

1990 • 37 citations

Monitoring of the mitochondrial and plasma membrane potentials in human fibroblasts by tetraphenylphosphonium ion distribution

1987 • 29 citations

Effect of aging on the oxidative phosphorylation pathway

1990 • 28 citations

Age changes of mitochondria of rat kidney

1982 • 27 citations

Age-dependent changes in pyruvate uptake by nonsynaptic and synaptic mitochondria from rat brain

1982 • 22 citations

Age dependent changes in the expression of Drosophila mitochondrial proteins

1986 • 22 citations

Flow-cytometric analysis of mitochondria-associated fluorescence in young and old human fibroblasts

1986 • 21 citations

Glucose Flux through the Hexose Monophosphate Shunt and NADP(H) Levels during in vitro Ageing of Human Skin Fibroblasts

1987 • 19 citations

Respiratory activity of isolated rat liver mitochondria following in vitro exposure to oxygen species: A threshold study

1990 • 19 citations

Decline in respiratory control ratio of rat liver mitochondria in old age

1981 • 19 citations

Comparison between proliferative changes and nuclear events during ageing of human fibrobalsts in vitro

1982 • 19 citations

Some biochemical properties of human lymphoblastoid Namalwa cells grown anaerobically.

1991 • 16 citations

Changes in mitochondrial DNA during aging

1982 • 11 citations

Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones

1991 • 7 citations

Japan's angel tours the sky

1990 • 4 citations

Mitochondrial antigenic structure and enzyme activity in ageing human diploid fibroblasts

1989 • 4 citations

Biochemical characterization of mitochondrial and lysosomal particles in old rat liver

1989 • 4 citations

Mitochondrial enzyme activity during in vitro ageing of human diploid fibroblasts

1987 • 1 citations