Reactive oxygen and DNA damage in mitochondria

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Rapid evolution of animal mitochondrial DNA.

1979 • 3,420 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Symbiosis in cell evolution

1981 • 1,386 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

BIOCHEMISTRY OF OXYGEN TOXICITY

1989 • 1,046 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Mitochondrial role in cell aging

1980 • 919 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Paternal inheritance of mitochondrial DNA in mice

1991 • 674 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

1969 • 382 citations

Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement

1992 • 371 citations

Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide

1986 • 349 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Origin and Evolution of Mitochondrial DNA

1989 • 311 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

1989 • 275 citations

Modern Biological Theories of Aging

1987 • 274 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae

1990 • 249 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Mutagenic spectrum resulting from DNA damage by oxygen radicals

1991 • 237 citations

Mitochondrial DNA Is a Major Cellular Target for a Dihydrodiol-Epoxide Derivative of Benzo[ a ]pyrene

1980 • 228 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Mitochondrial DNA mutations and neuromuscular disease

1989 • 216 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Reduced transcription of mitochondrial DNA in the senescent rat

1990 • 191 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Mitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues

1991 • 174 citations

Influence of Mitochondrial Radical Formation on Energy‐Linked Respiration

1978 • 168 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells.

1988 • 152 citations

Report of the committee on human mitochondrial DNA

1990 • 146 citations

Mitochondrial regulation of superoxide by Ca2+: An alternate mechanism for the cardiotoxicity of doxorubicin

1991 • 133 citations

Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea

1970 • 130 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

Lipofuscin: Fine-Structural and Biochemical Studies

1977 • 115 citations

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1991 • 110 citations

The genetic code in mitochondria and chloroplasts

1990 • 109 citations

Mitochondrial DNA analysis in Parkinson's disease

1990 • 109 citations

Menadione-(2-methyl-1,4-naphthoquinone) dependent enzymic redox cycling and calcium release by mitochondria

1986 • 100 citations

Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat

1988 • 98 citations

Quantitation of a mitochondrial DNA deletion in Parkinson's disease

1992 • 87 citations

Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA

1990 • 79 citations

Deleted mitochondrial DNA in the skeletal muscle of aged individuals.

1991 • 79 citations

Mitochondrial myopathies and respiratory chain proteins

1988 • 78 citations

Hydrogen peroxide production by mitochondria may be a biomarker of aging

1991 • 72 citations

Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo.

1988 • 70 citations

Mechanism of alloxan-induced calcium release from rat liver mitochondria.

1985 • 69 citations

Zur Biochemie der Thiolgruppe: Bedeutung des Glutathions

1989 • 59 citations

The 8-hydroxyguanine content of isolated mitochondria increases with lipid peroxidation

1990 • 53 citations

Mutations of mitochondrial DNA and human death

1990 • 50 citations

Mitochondrial diseases: Gene mapping and gene therapy

1990 • 44 citations

Mitochondrial DNA in sickness and in health.

1990 • 34 citations

Report of the committee on human mitochondrial DNA

1989 • 33 citations

2,3,7,8 Tetrachlorodibenzo-P-dioxin induces oxygen activation associated with cell respiration

1989 • 33 citations

Age-dependent covenant DNA alterations (I-compounds) in rat liver mitochondrial DNA

1990 • 33 citations

Complex forms and replicative intermediates of mitochondrial DNA in tissues from adult and senescent mice

1977 • 33 citations

Mitochondrial theory of senescence: Respiratory chain protein studies in human skeletal muscle

1991 • 31 citations

Mitochondrial genome in animal cells

1989 • 22 citations

Variation in the frequency of complex forms of mitochondrial DNA in different brain regions of senescent mice

1984 • 20 citations

Mitochondrial alterations in ageing mouse neuroblastoma cells in culture.

1984 • 9 citations

Mitochondrial DNA Mutations as an Etiology of Human Degenerative Diseases

1990 • 7 citations