Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.

A procedure for the isolation of deoxyribonucleic acid from micro-organisms

1961 • 11,554 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

1965 • 599 citations

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

1975 • 349 citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

1987 • 343 citations

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.

1986 • 328 citations

Peroxisome proliferation and hepatocarcinogenesis

1987 • 310 citations

INDIVIDUAL PEROXISOMAL βT‐OXIDATION ENZYMES*

1982 • 236 citations

Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators.

1982 • 182 citations

Mutagenesis by the autoxidation of iron with isolated DNA.

1988 • 158 citations

Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents.

1986 • 148 citations

Properties of hypolipidemic peroxisome proliferators in the lymphocyte [3H]thymidine and Salmonella mutagenesis assays.

1980 • 148 citations

Peroxisome proliferation and lipid peroxidation in rat liver.

1986 • 132 citations

Development of hepatocellular carcinomas and increased peroxisomal fatty acid β-oxidation in rats fed [4-chloro-6-(2, 3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14, 643) in the semipurified diet

1981 • 100 citations

Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.

1986 • 96 citations

Increased hydroxyl radical production in liver peroxisomal fractions from rats treated with peroxisome proliferators

1986 • 87 citations

Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat

1987 • 77 citations

In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F₁ mice to hepatic peroxisome proliferators

1986 • 75 citations

Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.

1988 • 55 citations

Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids

1975 • 54 citations

Molecular cloning of cDNA for rat acyl-CoA oxidase.

1984 • 52 citations