Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Biometry: The Principles and Practice of Statistics in Biological Research

1969 • 21,227 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Aging and Extrapyramidal Function

1977 • 650 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?

1990 • 563 citations

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

1989 • 504 citations

Free radicals, aging, and degenerative diseases

1987 • 375 citations

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

1992 • 354 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

Free radicals and myocardial ischemia: Overview and outlook

1988 • 286 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

1989 • 275 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

Reduction in regional cerebral metabolic rate of oxygen during human aging.

1986 • 260 citations

Neuropathologic and clinical features of Parkinson's disease in Alzheimer's disease patients

1987 • 254 citations

Imaging of the aging brain. Part I. Normal findings.

1988 • 250 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Magnetic Resonance Imaging of Brain Iron

1986 • 175 citations

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

1990 • 174 citations

Sensitivity of Cerebral Glucose Metabolism to Age, Gender, Brain Volume, Brain Atrophy, and Cerebrovascular Risk Factors

1988 • 168 citations

Report of the committee on human mitochondrial DNA

1990 • 146 citations

Deleted mitochondrial DNA in the skeletal muscle of aged individuals.

1991 • 79 citations

Cytochrome Oxidase Deficiency in Alzheimer's Diseasea

1991 • 79 citations

The neurology of aging: normal versus pathologic change.

1991 • 49 citations

Fate during cell growth of yeast mitochondrial and nuclear DNA after photolytic attachment of the monoazide analog of ethidium

1979 • 44 citations

Report of the committee on human mitochondrial DNA

1991 • 41 citations

Positron emission tomographic studies in aging and cerebrovascular disease at hammersmith hospital

1984 • 28 citations

Cerebral Blood Flow and Metabolism in Aging and Dementia

1991 • 23 citations