Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Cell Proliferation in Carcinogenesis

1990 • 1,063 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

The CpG dinucleotide and human genetic disease

1988 • 946 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

1991 • 627 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid

1991 • 530 citations

Chemical carcinogenesis: too many rodent carcinogens.

1990 • 498 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

1990 • 386 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Nonspecific defence mechanism: the role of nitric oxide

1991 • 325 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

1989 • 311 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Nitromation of amines by stimulated macrophages

1987 • 208 citations

Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide‐mediated killing

1993 • 196 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Chromosome Size-Dependent Control of Meiotic Recombination

1992 • 192 citations

Liver cancer in Thailand. I. A case‐control study of cholangiocarcinoma

1991 • 190 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

Mutagenicity of nitric oxide and its inhibition by antioxidants

1992 • 179 citations

DNA cytosine methylation and heat-induced deamination

1986 • 174 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Brain nitric oxide synthase is a haemoprotein

1992 • 151 citations

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

1991 • 148 citations

Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

1991 • 146 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in thailand

1991 • 100 citations

Neutrophil-mediated nitrosamine formation: Role of nitric oxide in rats

1992 • 88 citations

Purification of nitric oxide synthase from bovine brain: Immunological characterization and tissue distribution

1992 • 86 citations

Malignant Tumours of Liver and Lung in Rats fed Aminopyrine or Heptamethyleneimine together with Nitrite

1973 • 85 citations

Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages.

1992 • 81 citations

Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide

1993 • 80 citations

Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates

1989 • 78 citations

Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection.

1991 • 68 citations

Opisthorchis viverrini infection in Northeast Thailand and its relationship to cholangiocarcinoma

1992 • 68 citations

Nitrite from inflammatory cells—A cancer risk factor in ulcerative colitis?

1990 • 61 citations

Polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with Propionibacterium acnes and lipopolysaccharide

1992 • 58 citations

L-Arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-γ

1991 • 58 citations

Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats.

1992 • 53 citations

L'Abbé C

1950 • 50 citations

NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells

1993 • 48 citations

Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine sitmulated by Escherichia coli lipopolysaccharide in the rat

1991 • 48 citations

Mutagenicity of glyceryl trinitrate (nitroglycerin) in Salmonella typhimurium

1993 • 47 citations

Increased endogenous N-nitrosamine and nitrate formation by induction of nitric oxide synthase in rats with acute hepatic injury caused by Propionibacterium acnes and lipopolysaccharide administraction

1993 • 35 citations

Induction of Ca²⁺/calmodulin‐dependent NO synthase in various organs of rats by Propionibacterium acnes and lipopolysaccharide treatment

1992 • 33 citations

Marked nitrosation by stimulation with lipopolysaccharide in ascorbic acid-deficient rats

1990 • 26 citations

Generation of High Yields of Syrian Hamster Cholangiocellular Carcinomas and Hepatocellular Nodules by Combined Nitrite and Aminopyrine Administration and Opisthorchis viverrini Infection

1988 • 23 citations

Macrophage-mediated N-nitrosation of thioproline and proline

1989 • 14 citations

Effects of Escherichia coli lipopolysaccharide on nitrate synthesis and on nitrosation of proline in rats

1990 • 3 citations