RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

1995 • 1,116 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.

1992 • 808 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats.

1996 • 551 citations

ATTACHMENT AND CULTURE OF DISSOCIATED CELLS FROM RAT EMBRYO CEREBRAL HEMISPHERES ON POLYLYSINE-COATED SURFACE

1974 • 461 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

1994 • 397 citations

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

1995 • 358 citations

An immortalized cell line expresses properties of activated microglial cells

1992 • 356 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.

1993 • 298 citations

The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1993 • 295 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons.

1987 • 213 citations

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1995 • 187 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Activation of Macrophages by Alzheimer β Amyloid Peptide

1994 • 175 citations

α₁‐Antichymotrypsin Binding to Alzheimer Aβ Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

1993 • 143 citations

Heterogeneity of mouse vascular endothelium. In vitro studies of lymphatic, large blood vessel and microvascular endothelial cells.

1987 • 143 citations

Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor.

1991 • 102 citations

Paired helical filament tau in Alzheimer's disease. The kinase connection.

1994 • 102 citations

The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes

1992 • 94 citations

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

1993 • 55 citations

The Alzheimer's disease sphinx: a riddle with plaques and tangles.

1994 • 34 citations

Avid Binding of βA Amyloid Peptide to Its Own Precursor

1993 • 28 citations

Effect of Fatty Acid Profiles on the Susceptibility of Cultured Rabbit Tracheal Epithelial Cells to Hyperoxic Injury

1990 • 24 citations