AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

1957 • 4,140 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

The aging process.

1981 • 1,871 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Evolution of ageing

1977 • 1,784 citations

A theory of marginotomy

1973 • 1,770 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

Mitochondrial role in cell aging

1980 • 919 citations

The Prolongation of Life: Optimistic Studies

2003 • 889 citations

The evolution of ageing and longevity

1979 • 875 citations

Handbook of the Biology of Aging

1978 • 871 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

ON THE NATURE OF THE AGING PROCESS

1959 • 620 citations

General Theory of Mortality and Aging

1960 • 574 citations

[Principle of marginotomy in template synthesis of polynucleotides].

1971 • 566 citations

Body Size, Physiological Time, and Longevity of Homeothermic Animals

1981 • 414 citations

Handbook of the Biology of Aging

2005 • 413 citations

Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans s

1983 • 389 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1981 • 348 citations

Retarded Growth, Life Span, Ultimate Body Size and Age Changes in the Albino Rat after Feeding Diets Restricted in Calories

1939 • 347 citations

The uniqueness of the individual

1957 • 315 citations

Senescence in Plant Development

1961 • 273 citations

The Regulation of Physiological Changes During Mammalian Aging

1976 • 245 citations

Energy Metabolism, Brain Size and Longevity in Mammals

1983 • 241 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

1982 • 230 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Theories of biological aging

1985 • 212 citations

A membrane hypothesis of aging

1978 • 201 citations

Chromosome Damage in Human Diploid Cells following Activation of Lysosomal Enzymes

1965 • 199 citations

Evolution of human longevity and the genetic complexity governing aging rate.

1975 • 182 citations

Bioenergetics in aging

1983 • 180 citations

On the Statistical Nature of Mortality, with Especial Reference to Chronic Radiation Mortality

1956 • 169 citations

Molecular Biology of Aging: Gene Stability and Gene Expression

1986 • 163 citations

PHYSIOLOGICAL ECOLOGY

1981 • 156 citations

Testing the Commitment Theory of Cellular Aging

1977 • 154 citations

The Problem of Age, Growth, and Death

1907 • 147 citations

Genetic instability as the primary cause of human aging

1986 • 143 citations

Maturation and Longevity in Relation to Cranial Capacity in Hominid Evolution

1975 • 135 citations

The genetic program of cell death. hypothesis and some applications: Transformation, carcinogenesis, ageing

1982 • 133 citations

Testing the Theories of Aging

1983 • 132 citations

Biological aspects of aging

1962 • 127 citations

The rate of living : being an account of some experimental studies on the biology of life duration

1928 • 127 citations

Codon-restriction theory of aging and development

1971 • 124 citations

Intrinsic mutagenesis

1974 • 122 citations

Review Lectures on Senescence - I. The causes of ageing

1962 • 117 citations

Physiological Aspects of Aging in Man

1961 • 109 citations

Aging: Some Social and Biological Aspects

1961 • 106 citations

The ageing, growth and death of cells

1974 • 105 citations

Origin and Comparison of the Effects of Time and High-Energy Radiations on Living Systems

1959 • 100 citations

Advances in gerontological research

1965 • 98 citations

Hormone action during aging: Alterations and mechanisms

1979 • 96 citations

Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts

1980 • 96 citations

Aspects of the biology of ageing

1967 • 95 citations

Advances in gerontological research

1972 • 95 citations

The formation of altered enzymes in aging animals

1979 • 93 citations

Current status of age altered enzymes: Alternative mechanisms

1979 • 92 citations

PROLONGATION OF THE LIFE SPAN OF KOKANEE SALMON (ONCORHYNCHUS NERKA KENNERLYI) BY CASTRATION BEFORE BEGINNING OF GONAD DEVELOPMENT

1961 • 90 citations

The ageing of connective tissue.

1957 • 90 citations

Studies on aging in nematodes

1970 • 89 citations

Aging and Biological Rhythms

1978 • 88 citations

Big-bang reproduction and ageing in male marsupial mice

1982 • 87 citations

A model for ageing

1975 • 86 citations

Longevity, Aging, and Death: An Evolutionary Perspective

1978 • 85 citations

PERSPECTIVES IN EXPERIMENTAL GERONTOLOGY

1967 • 85 citations

DNA Repair in a Short-and a Long-lived Rodent Species

1979 • 84 citations

The genetics and cytology ofDrosophila Subobscura

1955 • 81 citations

Single-stranded regions in DNA of old mice

1975 • 78 citations

Longevity, stability and DNA repair

1979 • 77 citations

Repetition of molecular-genetic information as a possible factor in evolutionary changes of life span

1972 • 74 citations

Prolonging the Life Span

1934 • 74 citations

Intracellular determinants of cell aging

1984 • 73 citations

The Ageing of Connective Tissue

1957 • 73 citations

On the immortality of the germ line: Genetic and biochemical mechanisms. A review

1981 • 64 citations

Aging: The Loss of Temporal Organization

1968 • 63 citations

Structural and Functional Changes in Nucleoprotein During the Ageing of the Cell

1970 • 62 citations

On the role of cross-linking of cellular proteins in aging

1980 • 62 citations

STRESS AND AGING*

1970 • 61 citations

Evolutionary Theory in Gerontology

1982 • 60 citations

The Neuroendocrine System and Aging

1980 • 60 citations

Age-Specific Selection

1970 • 59 citations

ARTERIOSCLEROSIS IN MAN, OTHER MAMMALS AND BIRDS*

1964 • 57 citations

Current topics in cellular regulation

1985 • 56 citations

Handbook of Biochemistry in Aging

1982 • 55 citations

Temperature and Life-Span in Poikilothermous Animals

1962 • 51 citations

Aging and Life-Prolonging Processes

1982 • 51 citations

A COMMON MOLECULAR BASIS FOR THE AGING SYNDROME

1958 • 50 citations

Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neurospora crassa

1984 • 50 citations

Ueber die Dauer des Lebens

1890 • 46 citations

Selective loss of ribosomal RNA genes during the aging of post-mitotic tissues

1972 • 43 citations

Human mutations affecting aging — a review

1979 • 42 citations

Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review

1979 • 42 citations

Molecular versus systemic theories on the genesis of ageing

1968 • 42 citations

Redundancy of information content in the genome of mammalian species as a protective mechanism determining aging rate

1973 • 41 citations

Cell Biology of Aging

1975 • 40 citations

A Model of "regulatory" Aging of the Cell At the Gene Level

1966 • 39 citations

The Significance of DNA Methylation in Cellular Aging

1985 • 39 citations

Aging as entropy

1986 • 38 citations

Loss of gene repression activity: A theory of cellular senescence

1980 • 38 citations

Correlation between species life span and capacity to activate 7,12-dimethylbenz(a)anthracene to a form mutagenic to a mammalian cell

1975 • 38 citations

Reproduction and Death in Invertebrates and Fishes

1929 • 38 citations

Studies of Collagen Tissue Aging: Interaction of Certain Intermediary Metabolites with Collagen

1963 • 37 citations

Age changes of chromatin. A review

1984 • 34 citations

Biological significance of liver cell polyploidy: an hypothesis

1981 • 34 citations

Studies on the Comparative Physiology of Aging. II. On the Mechanism of Temperature Life-shortening in Drosophila Melanogaste

1961 • 34 citations

CROSSLINKAGE AND THE AGING PROCESS

1974 • 33 citations

Error propagation in intracellular information transfer

1980 • 32 citations

A Composite Theory of Aging

1966 • 32 citations

Cross-Linkage Hypothesis of Aging: DNA Adducts in Chromatin as a Primary Aging Process

1976 • 32 citations

Biological Mechanisms of Aging

1966 • 31 citations

THE COMPLEMENTARITY OF ENTROPY TERMS FOR THE TEMPERATURE‐DEPENDENCE OF DEVELOPMENT AND AGING*

1967 • 31 citations

A review of why and how we age: A defense of multifactorial aging

1987 • 31 citations

Beiträge zum Studium der Protoplasmahysteresis und der hysteretischen Vorgänge. (Zur Kausalität des Alterns.)

1924 • 30 citations

Aging, genetics, and the environment: Potential of errors introduced into genetic information transfer by metal ions

1979 • 28 citations

Heterochromatinization as a key factor in aging

1984 • 27 citations

Physiological and Pathological Ageing

1962 • 27 citations

Some physiological aspects of aging in man.

1956 • 27 citations

Aging: alteration of DNA-protein information.

1973 • 27 citations

Aging and the Lability of Irreplaceable Molecules

1957 • 27 citations

Aging: Alteration of DNA-Protein Information

1973 • 25 citations

Randomness, redundancy and repair: Roles and relevance to biological aging

1980 • 25 citations

Accelerated Ageing – a Long Term Effect of Exposure to Ionizing Radiations

1957 • 24 citations

Ontogenetic model of ageing and disease formation and mechanisms of natural selection

1986 • 24 citations

PHYSIOLOGICAL THEORIES OF AGING

1974 • 22 citations

Evolution and longevity-assurance processes

1981 • 22 citations

Increased levels of euploidy as a strategy against rapid ageing in diploid mammalian systems: An hypothesis

1977 • 22 citations

Aging and Levels of Biological Organization.

1965 • 21 citations

Mögliche Beziehungen der optischen Aktivität zum Problem des Alterns

1955 • 21 citations

Genetic and environmental influences on lifespan and diseases in Han:Wistar rats

1980 • 19 citations

Regulatory process in the mechanism of ageing

1968 • 18 citations

The role of infidelity of transfer of information for the accumulation of age changes in differentiated cells

1980 • 17 citations

Protein biosynthesis and problems of heredity, development and ageing

1967 • 16 citations

Senescence: A stochastic molecular control theory

1978 • 15 citations

A model to account for mortality curves of various species

1970 • 15 citations

Inverse Correlation Between Species Life Span and Specific Cytochrome P-448 Content of Cultured Fibroblasts

1982 • 15 citations

Disruptions in Enzyme Regulation during Aging

1975 • 14 citations

Stochastic studies of aging and mortality in multi-cellular organisms. I. The asymptotic theory

1978 • 14 citations

The multistep theory of aging: relation to the forbidden-clone theory. A theoretical article

1974 • 12 citations

Age-Related Changes of Transcription and RNA Processing

1986 • 11 citations

AN INTEGRATED THEORY OF AGING

1968 • 11 citations

The evolution of mutation rates via DNA base composition and mutator genes: A proposition

1976 • 10 citations

Aging As a Consequence of Growth Cessation

1965 • 9 citations

Longevity and Survival in Nematodes: Models and Mechanisms

1980 • 9 citations

Mammalian design and rate of living

1982 • 9 citations

The senescence of postmitotic mammalian cells: A cell-clock hypothesis

1984 • 9 citations

Developmental switches in reiterated genes may reduce the rate of age changes in DNA

1983 • 9 citations

A new unifying theory for the initiation of ageing mechanisms and processes

1973 • 7 citations

A deterministic mechanism for cellular and organismic ageing

1974 • 7 citations

[Aging of collagen].

1956 • 7 citations

Evolution of developmental rate in mammals

1982 • 6 citations

Conceptual Problems in Theoretical Gerontology

1983 • 6 citations

BIOLOGIC MECHANISMS OF AGING

1966 • 6 citations

Meine Theorie des Alterns und des Todes

1924 • 6 citations

A POSSIBLE CAUSE OF OLD AGE

1934 • 5 citations

MATHEMATICS OF MOLECULAR AGING MECHANISMS

1984 • 5 citations

Polygamy and the evolution of human longevity

1979 • 4 citations

A look at the basic correlates of longevity: Is longevity a superficial trait?

1978 • 4 citations

Molecular Mechanisms of Ageing

1992 • 2 citations

Genes and Aging

1978 • 2 citations