The role of iron in the initiation of lipid peroxidation

Free radicals in biology and medicine

1991 • 17,840 citations

Fenton's reagent revisited

1975 • 2,778 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution

1967 • 981 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.

1986 • 579 citations

Generation of Superoxide Free Radical during the Autoxidation of Thiols

1974 • 558 citations

The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.

1987 • 547 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Free radicals in biology and medicine

1985 • 416 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Pulse radiolytic studies of the reaction of perhydroxyl/superoxide O2- with iron(II)/iron(III) ions. The reactivity of HO2/O2- with ferric ions and its implication on the occurrence of the Haber-Weiss reaction

1985 • 329 citations

Evidence for the involvement of iron in the ADP-activatedperoxidation of lipids in microsomes and mitochondria

1964 • 267 citations

Unusual copper-induced sensitization of the biological damage due to superoxide radicals.

1981 • 240 citations

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

1983 • 234 citations

THE HABER‐WEISS CYCLE

1978 • 198 citations

Spin-trapping studies of hydroxyl radical production involved in lipid peroxidation

1978 • 168 citations

An investigation into the role of hydroxyl radical in xanthine oxidase-dependent lipid peroxidation

1982 • 159 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

Damaging effects of oxygen radicals on resealed erythrocyte ghosts.

1984 • 154 citations

Hydroxyl radical production involved in lipid peroxidation of rat liver microsomes

1977 • 151 citations

Superoxide generation by NADPH-cytochrome P-450 reductase: The effect of iron chelators and the role of superoxide in microsomal lipid peroxidation

1984 • 146 citations

Thiol-dependent lipid peroxidation

1982 • 142 citations

Role of superoxide radicals in the lipid peroxidation of intracellular membranes

1975 • 129 citations

The superoxide dismutase activity of iron complexes

1975 • 127 citations

The effect of pH on the conversion of superoxide to hydroxyl free radicals

1984 • 123 citations

ON THE GENERATION OF THE HYDROXYLATION AGENT FROM SUPEROXIDE RADICAL. CAN THE HABER–WEISS REACTION BE THE SOURCE OF OH RADICALS?

1978 • 118 citations

An attempt to demonstrate a reaction between superoxide and hydrogen peroxide

1976 • 116 citations

Ferrous ion-EDTA-stimulated phospholipid peroxidation. A reaction changing from alkoxyl-radical- to hydroxyl-radical-dependent initiation

1984 • 113 citations

The multiple effects of ethylenediaminetetraacetate in several model lipid peroxidation systems

1982 • 99 citations

Rat liver microsomal NADPH-dependent release of iron from ferritin and lipid peroxidation

1985 • 84 citations

Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles

1980 • 84 citations

Hydroxyl radical production in a purified NADPH-cytochrome c (P-450) reductase system

1979 • 77 citations

Superoxide and hydrogen peroxide-dependent lipid peroxidation in intact and Triton-dispersed erythrocyte membranes

1984 • 72 citations

Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation

1983 • 65 citations

Superoxide radical from xanthine oxidase acting upon lumazine

1985 • 39 citations

Iron-ethylenediaminetetraacetic acid (EDTA)-catalyzed superoxide dismutation revisited: An explanation of why the dismutase activity of Fe-EDTA cannot be detected in the cytochrome c/xanthine oxidase assay system

1982 • 31 citations

Superoxide-dependent redox cycling of citrate-Fe3+: Evidence for a superoxide dismutaselike activity

1987 • 30 citations

Putative superoxide dismutase activity of iron-EDTA: A reexamination

1980 • 29 citations