Mitochondrial DNA alterations as ageing-associated molecular events

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial role in cell aging

1980 • 919 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

1988 • 730 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?

1990 • 563 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

1989 • 504 citations

Deletions of mitochondrial DNA in Kearns‐Sayre syndrome

1988 • 354 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA

1990 • 341 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

Genes, Chromosomes, and Neoplasia

1981 • 264 citations

Oxygen Radicals and Tissue Injury

1997 • 257 citations

Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae

1990 • 249 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: Preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames

1987 • 214 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

1990 • 174 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice

1976 • 161 citations

Mitochondrial DNA sequences in the nuclear genome of a locust

1983 • 160 citations

Maternal inheritance of deleted mitochondrial DNA in a family with mitochondrial myopathy

1988 • 137 citations

Are mitochondrial DNA mutations involved in the carcinogenic process?

1987 • 133 citations

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1991 • 110 citations

A two-step hypothesis on the mechanisms of in vitro cell aging: Cell differentiation followed by intrinsic mitochondrial mutagenesis

1984 • 95 citations

Deleted mitochondrial DNA in the skeletal muscle of aged individuals.

1991 • 79 citations

Spectrophotofluorometric and Electron Microscopic Study of Lipofuscin Accumulation in the Testis of Aging Mice

1978 • 75 citations

Gene Transfera

1987 • 75 citations

Mitochondrial DNA and nuclear DNA from normal rat liver have a common sequence.

1983 • 75 citations

Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies

1991 • 70 citations

Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method

1989 • 60 citations

Three separate mitochondrial DNA sequences are contiguous in human genomic DNA

1989 • 59 citations

Ubisemiquinone radicals from the cytochrome b−c1 complex of the mitochondrial electron transport chain—Demonstration of QP-S radical formation

1981 • 54 citations

Review of cell aging in Drosophila and mouse

1979 • 51 citations

Aging-associated Deletions of Human Diaphragmatic Mitochondrial DNA

1992 • 50 citations

Role of metabolic rate and DNA-repair in Drosophila aging:

1983 • 49 citations

The ageing process

1993 • 43 citations

HeLaTG cells have mitochondrial DNA inserted into the c-myc oncogene.

1991 • 39 citations

Molecular biology of ageing.

1997 • 33 citations

Age-dependent 6kb deletion in human liver mitochondrial DNA.

1992 • 26 citations

Can migratory mitochondrial DNA activate oncogenes?

1983 • 25 citations

Age Dependent Changes in Mitochondria

1985 • 23 citations

Superproduction of heavy minicircular mitochondrial DNA in aging wheat coleoptiles

1992 • 21 citations

The presence of intact mitochondrial DNA in HeLa cell nuclei

1986 • 20 citations

Analysis of Mitochondrial DNA Mutations

2003 • 14 citations