A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

The aging process.

1981 • 1,871 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome

1989 • 1,009 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

DNA damage promotes jumping between templates during enzymatic amplification.

1990 • 510 citations

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

1989 • 504 citations

Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat

1969 • 382 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Progressive Increase of the Mutated Mitochondrial DNA Fraction in Kearns-Sayre Syndrome

1990 • 311 citations

In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria.

1991 • 297 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

Mitochondrial DNA mutations and neuromuscular disease

1989 • 216 citations

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome.

1989 • 212 citations

Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA

1980 • 201 citations

An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells

1991 • 198 citations

IN VIVO SOMATIC MUTATIONS IN HUMANS: MEASUREMENT AND ANALYSIS

1990 • 197 citations

Widespread tissue distribution of mitochondrial DNA deletions in Kearns‐Sayre syndrome

1990 • 152 citations

Mutation frequency in human lymphocytes increases with age

1984 • 138 citations

Cardiac Output and Regional Blood Flow

1963 • 122 citations

Deficient repair of chemical adducts in α DNA of monkey cells

1982 • 101 citations

Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro rat.

1989 • 80 citations

In Vitro Genetic Transfer of Protein Synthesis and Respiration Defects to Mitochondrial DNA-Less Cells with Myopathy-Patient Mitochondria

1991 • 76 citations

Chloroplast and Mitochondrial Mechanisms for Protection Against Oxygen Toxicity

1991 • 75 citations

Precise gene dosage determination by polymerase chain reaction: theory, methodology, and statistical approach

1991 • 60 citations

Different copy numbers of apparently identically deleted mitochondrial DNA in tissues from a patient with Kearns-Sayre syndrome detected by PCR

1990 • 38 citations

Marked increases of two kinds of two-exon-skipped albumin mRNAs with aging and their further increase by treatment with 3'-methyl-4-dimethylaminoazobenzene in Nagase analbuminemic rats.

1991 • 21 citations