Mechanisms of cellular senescence

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process

1966 • 831 citations

Life Span of Individual Yeast Cells

1959 • 754 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

1987 • 709 citations

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

1991 • 700 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature

1984 • 594 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

1994 • 547 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1995 • 496 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

Excess of rare cancers in Werner syndrome (adult progeria).

1996 • 435 citations

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

1989 • 417 citations

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

1995 • 406 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

1996 • 390 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

1995 • 366 citations

Genetic analysis of indefinite division in human cells: identification of four complementation groups.

1988 • 358 citations

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

1981 • 348 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Epigenetic inheritance of transcriptional states in S. cerevisiae

1989 • 327 citations

Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.

1994 • 309 citations

Loss of Transcriptional Silencing Causes Sterility in Old Mother Cells of S. cerevisiae

1996 • 308 citations

Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.

1986 • 305 citations

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1996 • 291 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression.

1996 • 270 citations

Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent

1996 • 265 citations

Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme

1995 • 252 citations

Cytogenetics of Werner’s syndrome cultured skin fibroblasts: variegated translocation mosaicism

1981 • 241 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae

1989 • 211 citations

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

1993 • 207 citations

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1996 • 201 citations

A novel mechanism for telomere size control in Saccharomyces cerevisiae.

1996 • 199 citations

Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.

1995 • 196 citations

The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing.

1995 • 180 citations

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein.

1996 • 163 citations

The gene responsible for Werner syndrome may be a cell division "counting" gene.

1993 • 157 citations

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

1996 • 157 citations

In situ analysis of changes in telomere size during replicative aging and cell transformation.

1996 • 152 citations

Telomere telomere recombination provides an express pathway for telomere acquisition

1990 • 146 citations

Chemokine Receptors and HIV-1: An Attractive Pair?

1996 • 146 citations

Genetic Analysis of the Roles of daf28 and age-1 in Regulating Caenorhabditis elegans Dauer Formation

1996 • 129 citations

Telomere length constancy during aging of Saccharomyces cerevisiae

1991 • 96 citations

Parental age and the life-span of zygotes of Saccharomyces cerevisiae

1985 • 70 citations

Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells

1990 • 58 citations

Do Changes in Chromosomes Cause Aging?

1996 • 56 citations

DNA Repair Fine Structure in Werner's Syndrome Cell Lines

1996 • 35 citations

Expression of p24, a novel p21 ^{Waf1/Cip1/Sdi1} -related protein, correlates with measurement of the finite proliferative potential of rodent embryo fibroblasts

1997 • 17 citations