Free Radical Involvement in Aging

Free radicals in biology and medicine

1991 • 17,840 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Aging, Natural Death, and the Compression of Morbidity

1980 • 3,304 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

[44] Glutathione peroxidase

1981 • 2,990 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Free Radicals in Biology

1976 • 1,879 citations

The aging process.

1981 • 1,871 citations

Accelerated Atherosclerosis in Prolonged Maintenance Hemodialysis

1974 • 1,789 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

Glutathione: Metabolism and function

1978 • 971 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Mitochondrial role in cell aging

1980 • 919 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Protein glycation and oxidative stress in diabetes mellitus and ageing

1991 • 882 citations

Free radical theory of aging

1992 • 876 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

DNA Repair in Bacteria and Mammalian Cells

1979 • 854 citations

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

1991 • 788 citations

Atmospheric Oxidation and Antioxidants

1993 • 782 citations

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.

1988 • 765 citations

The Origin of Life.

1938 • 637 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

In Search of Methuselah: Estimating the Upper Limits to Human Longevity

1990 • 623 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 • 573 citations

PREDIAGNOSTIC SERUM SELENIUM AND RISK OF CANCER

1983 • 556 citations

Chemical evolution

1961 • 555 citations

Lipoproteins and Atherogenesis

1990 • 549 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Complement-Induced Granulocyte Aggregation

1980 • 520 citations

Superoxide and superoxide dismutases

1993 • 518 citations

Chemical carcinogenesis: too many rodent carcinogens.

1990 • 498 citations

AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING

1990 • 490 citations

Free Radical Chemistry

1988 • 484 citations

Changes in Risk Factors and the Decline in Mortality from Cardiovascular Disease

1990 • 482 citations

Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

1976 • 465 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Progress against Cancer?

1986 • 420 citations

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

1989 • 417 citations

Dietary pesticides (99.99% all natural).

1990 • 400 citations

The Immunologic Theory of Aging

1971 • 363 citations

Antioxidant nutrients and disease prevention: an overview

1991 • 344 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

DIETARY FACTORS ASSOCIATED WITH DEATH-RATES FROM CERTAIN NEOPLASMS IN MAN

1966 • 311 citations

Spontaneous cancer and its possible relationship to oxygen metabolism.

1980 • 298 citations

Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen

1991 • 298 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Genetic syndromes in man with potential relevance to the pathobiology of aging.

1978 • 290 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Nature's chemicals and synthetic chemicals: comparative toxicology.

1990 • 275 citations

Modern Biological Theories of Aging

1987 • 274 citations

Nutrition in Relation to Cancer.

1948 • 256 citations

DNA Damage as the Primary Cause of Aging

1981 • 248 citations

Reduction by Cimetidine of Serum Parathyroid Hormone Levels in Uremic Patients

1980 • 247 citations

Action of food restriction in delaying the aging process.

1982 • 243 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Mechanisms of cell death

1989 • 237 citations

Antioxidants and Aging

2012 • 235 citations

Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of breast cancer

1984 • 229 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

Oncogenes and Tumor-Suppressing Genes

1988 • 222 citations

Handbook of Aging and the Individual

1961 • 217 citations

Role of Free Radicals in Mutation, Cancer, Aging, and the Maintenance of Life

1962 • 204 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

Metabolism of Oxygen Derivatives in Down's Syndrome*

1982 • 199 citations

The role of calcium in cell killing

1990 • 199 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Free radical theory of aging: The “free radical” diseases

1984 • 192 citations

Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

1990 • 189 citations

Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of breast cancer

1988 • 180 citations

Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster

1990 • 180 citations

Selenium in human nutrition: Dietary intakes and effects of supplementation

1978 • 177 citations

Uric acid is a major antioxidant in human nasal airway secretions.

1990 • 173 citations

Influence of Mitochondrial Radical Formation on Energy‐Linked Respiration

1978 • 168 citations

Radiation-induced arterial injuries.

1983 • 166 citations

Age-related changes in lipid peroxidation as measured by ethane, ethylene, butane and pentane in respired gases of rats

1980 • 162 citations

Superoxide anion radical production in different animal species

1989 • 162 citations

Protein Modification in Aging

1988 • 160 citations

THE CROSSLINKAGE THEORY OF AGING

1968 • 149 citations

Fluid Dynamics as a Localizing Factor for Atherosclerosis

1983 • 144 citations

Tocopherol, Oxygen and Biomembranes

1978 • 144 citations

Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms

1989 • 143 citations

Breath pentane analysis as an index of lipid peroxidation: a functional test of vitamin E status

1987 • 143 citations

Copper(II)‐catalyzed lipid peroxidation in liposomes and erythrocyte membranes

1982 • 138 citations

Regulation of mitochondrial respiration in senescence

1972 • 135 citations

Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.

1985 • 131 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Expression of Bovine Superoxide Dismutase in Drosophila melanogaster Augments Resistance to Oxidative Stress

1991 • 117 citations

Protein modification in aging

1992 • 116 citations

Immunobiology of aging: Evaluation of current status

1976 • 115 citations

Expression of supreoxide dismutase and catalase in rat brain as a function of age

1991 • 111 citations

Theoretical of Aspects of Aging

1974 • 109 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

Cardiovascular Research: Decades of Progress, a Decade of Promise

1982 • 106 citations

Evolution of Sexual Reproduction: Importance of DNA Repair, Complementation, and Variation

1981 • 106 citations

Modification of mitochondrial respiration by aging and dietary restriction

1980 • 106 citations

Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down's syndrome

1991 • 105 citations

Free radical theory of aging: History

1992 • 102 citations

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice

1984 • 101 citations

Lipofuscin and Ceroid Pigments

1989 • 101 citations

The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals

1981 • 99 citations

Lipofuscin and Ceroid Formation: The Cellular Recycling System

1990 • 99 citations

Vascular injury and atherosclerosis

1981 • 98 citations

Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase

1980 • 95 citations

Depolymerization of hyaluronic acid by autoxidants and radiatiions.

1966 • 94 citations

Free Radical Theory of Aging: Effect of the Amount and Degree of Unsaturation of Dietary Fat on Mortality Rate

1971 • 93 citations

Modulation of free radicals and superoxide dismutases by age and dietary restriction

1990 • 90 citations

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients

1990 • 87 citations

Selenium concentrations in plasma of patients with arteriographically defined coronary atherosclerosis.

1984 • 86 citations

Ionizing Radiation and the Aging Process: A Review

1957 • 85 citations

Antioxidants, metabolic rate and aging in Drosophila

1982 • 84 citations

Studies on ageing in nematodes IV. The effect of anti-oxidants on cellular damage and life span

1972 • 81 citations

Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice

1979 • 80 citations

Structure of Collagen From Human Tendon As Influenced by Age and Sex

1965 • 79 citations

Free Radical Theory of Aging: Effect of Free‐Radical‐Reaction Inhibitors on the Immune Response†

1977 • 78 citations

Free radical theory of aging: Beneficial effect of antioxidants on the life span of male NZB mice; role of free radical reactions in the deterioration of the immune system with age and in the pathogenesis of systemic lupus erythematosus

1980 • 78 citations

Structural changes in microsomal suspensions

1965 • 78 citations

Dietary guidelines and the results of food consumption surveys

1991 • 77 citations

Free radical theory of aging: Nutritional implications

1978 • 76 citations

Recognition and Uptake of Human Diabetic Peripheral Nerve Myelin by Macrophages

1985 • 76 citations

Energy Metabolism in Anaerobes

1970 • 72 citations

The Free Radical Theory of Aging: The Effect of Age on Serum Mercaptan Levels

1960 • 72 citations

Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance.

1985 • 70 citations

Free radicals and the action of inhibitors of radical processes under pathological states and ageing in living organisms and in man

1976 • 70 citations

Effect of age on the function of mitochondria isolated from brain and heart tissue

1980 • 69 citations

α-Tocopherol increases lifespan in the rotifer Philodina

1980 • 68 citations

Specific Macrophage Receptor Activity for Advanced Glycosylation End Products Inversely Correlates With Insulin Levels In Vivo

1988 • 68 citations

The natural history of neoplastic development:The relation of experimental models to human cancer

1982 • 67 citations

Role of Calcium in Toxic and Programmed Cell Death

1991 • 67 citations

Atherosclerosis: A Hypothesis Concerning the Initiating Steps in Pathogenesis

1957 • 65 citations

On the immortality of the germ line: Genetic and biochemical mechanisms. A review

1981 • 64 citations

Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice

1986 • 63 citations

DNA Damage and Repair during Cellular Aging

1989 • 61 citations

Effects of the Antioxidant Butylated Hydroxytoluene (BHT) on Mortality in BALB/c Mice

1979 • 60 citations

De novo synthesis of glutathione in human fibroblasts during in vitro ageing and in some metabolic diseases as measured by a flow cytometric method

1986 • 59 citations

Cholesterol diet and permeability of rabbit aorta

1971 • 59 citations

Alzheimer's disease, Down's syndrome, and aging.

1982 • 58 citations

SPECIFIC CHEMICAL DISSOCIATION OF FIBRILLAR AND NON-FIBRILLAR COMPONENTS OF AMYLOID DEPOSITS

1984 • 58 citations

The life puzzle

1974 • 57 citations

Long-term effects of a single whole-body exposure of mice to ionizing radiations I. Life-shortening

1961 • 56 citations

SIMILARITIES AND CONTRAST BETWEEN RADIATION AND TIME PATHOLOGY.

1964 • 55 citations

Ageing of Neurospora crassa. I. Evidence for the free radical theory of ageing from studies of a natural-death mutant

1976 • 54 citations

Free Radical Theory of Aging: Inhibition of Amyloidosis in Mice by Antioxidants; Possible Mechanism*

1976 • 53 citations

Biochemical evolution and the origin of life.

1972 • 52 citations

Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary

1985 • 52 citations

Review of cell aging in Drosophila and mouse

1979 • 51 citations

Mortality among health-conscious elderly Californians.

1982 • 51 citations

Effectiveness of antioxidants in refined, bleached and deodorized palm olein

1983 • 51 citations

Germ line recombination may be primarily a manifestation of DNA repair processes

1977 • 48 citations

Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring; possible explanation of the sex difference in longevity

1979 • 48 citations

Age-related changes in the redox status of rat muscle cels and their role in enzyme-aging

1985 • 48 citations

Evidence for one-electron transfer by the Fe protein of nitrogenase

1978 • 45 citations

Amino Acid Composition of Human Aortic Elastin as Influenced by Age

1966 • 44 citations

Isolation of α-amino adipic acid from mature dermal collagen and elastin. Evidence for an oxidative pathway in the maturation of collagen and elastin

1977 • 42 citations

Evidence for increased degeneration of mitochondria in old rats. A brief note

1978 • 41 citations

The Effect of Age and Protein Deprivation on the Sulfhydryl Content of Serum Albumin

1970 • 39 citations

Evolution. Concepts and consequences

1976 • 39 citations

Normal CuZn Superoxide Dismutase, Mn Superoxide Dismutase, Catalase and Glutathione Peroxidase in Werner's Syndrome.

1981 • 39 citations

ONCOGENES

1983 • 37 citations

The Respiratory Burst of Phagocytic Cells: Facts and Problems

1982 • 33 citations

Tissue Vitamin E Levels and Lipofuscin Accumulation With Age in the Mouse

1981 • 32 citations

[Biological aspects of aging].

1989 • 32 citations

Atherosclerosis

1962 • 30 citations

Aging and age-related diseases normal processes

1985 • 28 citations

Free radical theory of aging: Effects of antioxidants on mitochondrial function

1987 • 27 citations

The relation of human health to age, place, and time

1960 • 26 citations

Normal copper zinc super oxide dis mutase manganese super oxide dis mutase catalase and glutathione peroxidase in werners syndrome

1981 • 26 citations

Jay K. Kochi (Ed.): Free Radicals. Vol. I, Part I: Dynamics of Elementary Processes. Wiley Interscience, New York 1973. 713 Seiten. Preis: £ 18.75.

1974 • 25 citations

Recombinational Repair May Be an Important Function of Sexual Reproduction

1983 • 25 citations

Increased disulfide-mediated condensation of the nuclear DNA-protein complex in lymphocytes during postnatal development and aging

1982 • 22 citations

Prospects for further increase in average longevity.

1957 • 22 citations

Genesis on planet Earth

1979 • 20 citations

Long-term effects of a single whole-body exposure of mice to ionizing radiation. I. Life-shortening

1961 • 20 citations

Lung antioxidant enzymes, peroxidation, glutathione system and oxygen consumption in catalase inactivated young and old Rana perezi frogs

1990 • 20 citations

THE CARDIOVASCULAR SYSTEM AND RADIATION

1983 • 18 citations

DNA Repair Processes

1984 • 18 citations

Atherosclerosis

1962 • 15 citations

Genetical, developmental, and thermal regulation of antioxidant enzymes in Neurospora

1990 • 13 citations

Mineral insufficiency and cancer

1990 • 13 citations

Glutathione content of cultured human fibroblasts during in vitro ageing

1984 • 13 citations

[Retarding action of nordihydroguiaiaretic acid on aging in the rat].

1959 • 12 citations

Free Radicals in Photosynthesis

1976 • 11 citations

Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in nuerospora

1990 • 10 citations

Fluid Dynamic Approaches to Atherosclerosis

1983 • 9 citations

Age Dependency of Base Modification in Rabbit Liver DNA

1988 • 9 citations

Pharmacogenetics of cylic guanylate, antioxidants, and antioxidants enzymes in saccharomyces

1990 • 5 citations

Human carcinogenesis—introductory remarks

1991 • 5 citations

On the Opportunities and Needs for a Medical Institution in Massachusetts

1933 • 4 citations

Deleted Work

1955 • 0 citations