Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

1994 • 2,067 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related Compounds

1993 • 541 citations

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca²⁺ and Na⁺: Implications for Neurodegeneration

1994 • 492 citations

Involvement of Free Radicals in Excitotoxicity In Vivo

1995 • 325 citations

Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate

1993 • 303 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

Inhibition of Succinate Dehydrogenase by Malonic Acid Produces an “Excitotoxic” Lesion in Rat Striatum

1993 • 206 citations

Coenzyme Q₁₀ and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

1994 • 192 citations

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

1992 • 167 citations

Limiting Ischemic Injury by Inhibition of Excitatory Amino Acid Release

1993 • 154 citations

Neurochemical and Behavioral Aspects of Lamotrigine

1991 • 142 citations

Therapy of mitochondrial disorders

1987 • 104 citations

Ubiquinone Protects Cultured Neurons against Spontaneous and Excitotoxin-Induced Degeneration

1992 • 98 citations

Malonate produces striatal lesions by indirect NMDA receptor activation

1994 • 88 citations

In Vivo Spin Trapping of Xenobiotic Free Radical Metabolites

1993 • 87 citations

Lamotrigine protects against kainate but not ibotenate lesions in rat striatum

1990 • 77 citations

The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease

1994 • 52 citations