Potential genotoxicity of chronically elevated nitric oxide: A review

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

1991 • 784 citations

Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence

1975 • 759 citations

Endogenous mutagens and the causes of aging and cancer

1991 • 725 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Nitrate biosynthesis in man.

1981 • 677 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Nitrate Synthesis in the Germfree and Conventional Rat

1981 • 551 citations

Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus

1980 • 506 citations

A Textbook of Modern Toxicology

2004 • 499 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

1980 • 367 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Synthesis of nitrite and nitrate in murine macrophage cell lines.

1987 • 335 citations

N-Nitroso compounds: occurrence, biological effects and relevance to human cancer

1985 • 316 citations

Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism.

1991 • 296 citations

Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine

1978 • 292 citations

Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.

1991 • 291 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

The biological role of nitric oxide in bacteria

1993 • 285 citations

Hepatocarcinogenicity of the woodchuck hepatitis virus.

1987 • 273 citations

Nitrosation, diazotisation, and deamination

1961 • 256 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Inflammation, chromosomal instability, and cancer: the schistosomiasis model.

1994 • 229 citations

Nitromation of amines by stimulated macrophages

1987 • 208 citations

Inhibition by nitric oxide of the repair protein, O⁶-DNA-methyltransferase

1994 • 195 citations

N -Nitrosation by Nitrite Ion in Neutral and Basic Medium

1973 • 182 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

Mutagenicity of nitric oxide and its inhibition by antioxidants

1992 • 179 citations

A textbook of modern toxicology

1987 • 166 citations

Woodchuck hepatitis and hepatocellular carcinoma: Correlation of histologic with virologic observations

1981 • 152 citations

Endogenous nitric oxide induced by interleukin‐1β in rat islets of Langerhans and HIT‐T15 cells causes significant DNA damage as measured by the ‘comet’ assay

1993 • 137 citations

Liver fluke infection and cholangiocarcinoma: model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis

1994 • 137 citations

Involvement of inflammatory reactions and elevated cell proliferation in the development of bladder cancer in schistosomiasis patients

1994 • 130 citations

Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains

1985 • 123 citations

Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes

1992 • 123 citations

N-Nitroso Compounds in the Environment.

1975 • 120 citations

Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People's Republic of China.

1990 • 115 citations

Nitrosamine Formation by Denitrifying and Non-denitrifying Bacteria: Implication of Nitrite Reductase and Nitrate Reductase in Nitrosation Catalysis

1988 • 113 citations

In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporozoites, malaria blood parasites or adjuvants

1993 • 109 citations

The Role of Cell Types in Hepatocarcinogenesis

1992 • 108 citations

Urinary excretion of nitrate, nitrite and N-nitroso compounds in Schistosomiasis and bilharzia bladder cancer patients

1989 • 104 citations

Human exposure to endogenous N-nitroso compounds: quantitative estimates in subjects at high risk for cancer of the oral cavity, oesophagus, stomach and urinary bladder.

1989 • 101 citations

opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in thailand

1991 • 100 citations

Differential Induction of Nitric Oxide Synthase in Hepatocytes During Endotoxemia and the Acute-Phase Response

1994 • 98 citations

Induction of mutations and chromosome aberrations in lung cells following in vivo exposure of rats to nitrogen oxides

1984 • 98 citations

Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach

1987 • 97 citations

Relevance of N-Nitroso Compounds to Human Cancer. Exposures and Mechanisms.

1988 • 95 citations

Nitrate Contamination: Exposure, Consequence, and Control

1992 • 94 citations

Kupffer cell: Hepatocyte cocultures release nitric oxide in response to bacterial endotoxin

1990 • 93 citations

Mutations induced by saturated aqueous nitric oxide in the pSP189 supF gene in human Ad293 and E. coli MBM7070 cells

1993 • 91 citations

Increased nitrosamine and nitrate biosynthesis mediated by nitric oxide synthase induced in hamsters infected with liver fluke (Opisthorchis viverrini)

1994 • 89 citations

Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers.

1994 • 87 citations

DNA Sequence Changes Induced by Two Nitric Oxide Donor Drugs in the supF Assay

1994 • 85 citations

The epidemiology of gastric cancer

1991 • 80 citations

Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates

1989 • 78 citations

Nitrite and nitrosamine synthesis by hepatocytes isolated from normal woodchucks (Marmota monax) and woodchucks chronically infected with woodchuck hepatitis virus.

1992 • 74 citations

Influence of ascorbic acid dose on N-nitrosoproline formation in humans

1987 • 74 citations

Mechanism for nitrosation of 2,3-diaminonaphthalene by Escherichia coli: enzymatic production of NO followed by O2-dependent chemical nitrosation

1988 • 69 citations

Chronic hepatitis and hepatocellular carcinoma associated with woodchuck hepatitis virus.

1982 • 69 citations

NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.

1990 • 68 citations

Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection.

1991 • 68 citations

Opisthorchis viverrini infection in Northeast Thailand and its relationship to cholangiocarcinoma

1992 • 68 citations

Nitric Oxide Synthase Expression Is Induced in Hepatocytes in Vivo during Hepatic Inflammation

1993 • 68 citations

Cellular and Molecular Mechanisms of Hepatocarcinogenesis

1992 • 67 citations

Helicobacter pylori and gastric cancer

1993 • 62 citations

Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli

1988 • 60 citations

The chemistry of nitroso compounds. Part 12. The mechanism of nitrosation and nitration of aqueous piperidine by gaseous dinitrogen tetraoxide and dinitrogen trioxide in aqueous alkaline solutions. Evidence for the existence of molecular isomers of dinitrogen tetraoxide and dinitrogen trioxide

1978 • 57 citations

Biochemical studies on the catalysis of nitrosation by bacteria

1987 • 53 citations

Review of the genotoxicity of nitrogen oxides

1994 • 52 citations

Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine sitmulated by Escherichia coli lipopolysaccharide in the rat

1991 • 48 citations

Safety evaluation of nitrosatable drugs and chemicals

1983 • 42 citations

Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis.

1989 • 41 citations

N-nitrosamine formation by intestinal bacteria.

1984 • 41 citations

Increased endogenous N-nitrosamine and nitrate formation by induction of nitric oxide synthase in rats with acute hepatic injury caused by Propionibacterium acnes and lipopolysaccharide administraction

1993 • 35 citations

N-nitrosamine formation in urinary-tract infections.

1987 • 29 citations

Synthesis of nitric oxide and nitrosamine by immortalized woodchuck hepatocytes

1993 • 26 citations

Isolation of an enzyme catalysing nitrosamine formation in Pseudomonas aeruginosa and Neisseria mucosae

1990 • 21 citations

Increased urinary nitrosamine excretion in patients with urinary diversions

1989 • 20 citations

High urinary excretion of nitrate and N-nitrosoproline in opisthorchiasis subjects.

1987 • 19 citations

Bacterially mediated N-nitrosation reactions and endogenous formation of N-nitroso compounds.

1987 • 17 citations

N-nitrosamine formation by microorganisms isolated from human gastric juice and urine: biochemical studies on bacteria-catalysed nitrosation.

1987 • 14 citations

Nitrate balance and biosynthesis in the ferret

1984 • 12 citations

Hepatocytes enhance Kupffer cell-mediated tumor cell cytostasis in vitro.

1989 • 9 citations

Quantifying Gastric Nitrate and Nitrate Reductase Activity in the Normal and Achlorhydric Stomach

1991 • 3 citations

Deleted Work

1955 • 0 citations